UW Research

Oncology-Related Research

It is challenging for UW researchers to identify which IRB should review oncology-related research. This is because:

  • Oncology-related research and clinical care in the region have a long rich history of collaboration.
  • The research often occurs in physical locations (such as SCCA) that involve multiple regional institutions.
  • Federal funding agencies, consortia, and national network groups have specific IRB requirements.

Which IRB should do the review for UW oncology-related research?

The UW IRB does not have sufficient oncology expertise to review most oncology research. See below to identify the external IRB that should review UW oncology research.

CITN studies
Cancer Immunotherapy Network (CITN) studies must be reviewed by the National Cancer Institute’s Central IRB. See How Ask for a Non-UW IRB to initiate the process. Then work with the Cancer Consortium’s Clinical Research Support office to obtain the IRB review.

Industry oncology research
Must be reviewed by Advarra, Fred Hutchinson Cancer Research Center, or WIRB. See How to Ask for a Non-UW IRB to initiate the process.

NMDP and CIBMTR studies
Bone marrow donation or transplantation research involving the National Marrow Donor Program (NMDP) or the Center for International Blood and Marrow Transplant Research (CIBMTR) must be reviewed by the NMDP IRB. See How to Ask for a Non-UW IRB to initiate the process.

NCTN and cooperative intervention studies
National Clinical Trials Network and cooperative group intervention studies must be reviewed by the National Cancer Institute’s Central IRB. See How to Ask for a Non-UW IRB to initiate the process. Then work with the Cancer Consortium’s Clinical Research Support office to obtain the IRB review.

Pediatric oncology trials
These must be reviewed by the Seattle Children’s IRB or the Fred Hutchinson Cancer Research Center IRB unless the National Cancer Institute has informed the lead researcher that the NCI Central IRB will do the review. See How to Ask for a Non-UW IRB to initiate the process.

All other oncology studies not described above
The IRB that does the review depends on (1) the nature of the UW’s participation; (2) which other institutions are involved in the research; and (3) the level of risk to the research participants. Consult with HSD at hsdrely@uw.edu If you are not sure which IRB is appropriate.

Participating site in a multi-site study
The IRB is chosen by the lead site or coordinating center. See How to Ask for a Non-UW IRB to initiate the process.
Research involves more than minimal risk to subjects, and the institutions that are involved are all members of the Cancer Consortium. The Hutch IRB does the review. See How to Ask for a Non-UW IRB to initiate the process.

Research involves more than minimal risk to subjects, the UW is the lead site or coordinating center, and one or more institutions are NOT members of the Cancer Consortium.
If a Hutch investigator is also involved in the research, the Hutch IRB will do the review. Otherwise the Hutch IRB will not do these reviews; consult with HSD at hsdrely@uw.edu to identify the most appropriate IRB.

Research involves more than minimal risk to subjects, and the institutions that are involved are all members of the Cancer Consortium. The Hutch IRB does the review. See How to Ask for a Non-UW IRB to initiate the process.

Minimal risk oncology research
The UW IRB will do the review.

What to do if FHCRC will do the review

Follow the instructions for How to Ask for a Non-UW IRB. Be sure to identify all institutions (regional or otherwise) that are working with the UW researcher.

What to do if UW will do the review

Submit an application in the UW’s Zipline e-IRB system. Be sure to identify all institutions, including members of the Cancer Consortium, that will be involved in the research.

Any Hutch investigators involved in the research must submit an External IRB Cover Sheet – New Application and the prepared UW IRB application materials to the Fred Hutch Institutional Review Office (IRO). Email submissions to IRBInbox@fredhutch.org. The IRO will perform a quality check on outgoing applications to ensure institutional requirements are met. Once complete, the IRO will send a signed endorsement form to proceed with external IRB review.

Guide for FHCRC and Seattle Children’s Researchers

Use this guide to identify whether there is UW involvement in a FHCRC or Seattle Children’s study that requires IRB review. GUIDE: FHCRC and Seattle Children’s Investigators: UW Engagement in Human Subjects Research.