If revenue (from the sale of goods or services) is being generated by an activity, then a Service or Recharge Center needs to be established. See Management Accounting and Analysis (MAA) for more information.
If the revenue being generated is from a federally-sponsored award then it is considered to be Program Income and needs to be reported to the federal sponsor. See the GCA links for more information on Program Income: Grant and Contract Accounting (GCA).
Grant and Contract Accounting Program Income Guidelines