Fostering collaborative work among researchers at the three partner institutions – UW Medicine, The Fred Hutchinson Cancer Center, and Seattle Children’s Hospital.
Core Services Offered
Combining leading-edge science and technology, BBI’s commitment to precision medicine extends beyond the institute’s own faculty and researchers, offering its knowledge and expertise, as well as data, tools, and platforms, to assist others solving problems and achieving their goals. These platforms include: single cell genomics, cell-free DNA diagnostics, a genome center, and pathogen diagnostics.
- Single Cell Sequencing and Bioinformatics; Saturation Genome Editing; Pathogen Detection
- Genome sequencing
- Precision Diagnostics
- Targeted Long Read Sequencing
- In collaboration with the UW Department of Genome Sciences and the Allen Discovery Center for Cell Lineage Tracing, BBI offers data, tools, tutorials and other services to assist researchers exploring a wide range of bioscientific endeavors. These include:
- Human Gene Expression and Human Chromatin Accessibility During Development; Mammalian Organogenesis; Mouse and Fly Chromatin Accessibility; and Worm Gene Expression
- Database of Functional Classifications of BRCA1Variants based on Saturation Genome Editing
- Database of Multiplexed Assays of Variant Effects (MaveDB), such as those generated by deep mutational scanning (DMS) or massively parallel reporter assay (MPRA) experiments
- The BBI Granting Program
- BBI Events
NOTE: BBI also is funding innovative whole genome sequencing of infants suspected of having developmental disabilities to identify more precise diagnoses more quickly than conventional processes and to offer better care more efficiently. See: https://brotmanbaty.org/research/seqfirst
The institute is overseen by the BBI Scientific Director and advised by the BBI Governance Committee, the BBI Advisory Board, and the BBI Management Committee.
Related UW Entities
BBI members represent the following:
Schools of Medicine, Pharmacy, and Public Health.
Departments of: Genome Sciences; Laboratory Medicine and Pathology; Electrical & Computer Engineering; Biochemistry; Pediatrics; Radiology; Biological Structure; Psychiatry and Behavioral Sciences; Urology; Neurology; Physiology & Biophysics; Epidemiology; Global Health; Orthopedics and Sports Medicine; Medical Oncology; Ophthalmology; Biological Physics, Structure & Design; Biomedical Informatics & Medical Education; Surgery; Anesthesiology and Pain Medicine; Immunology; Microbiology; Obstetrics & Gynecology; Radiation; and Oncology.
Fred Hutchinson Cancer Center and Seattle Children’s Hospital