The Physiome Project aims to develop, collect, preserve, and disseminate information and integrated understandings of functional biological systems. Going beyond experimentation and observation, the key elements of the project are the databasing of physiological, pharmacological, and pathological information on humans and other organisms and integration through computational modeling. "Models" include everything from diagrammatic schema, suggesting relationships among elements composing a system, to fully quantitative, computational models describing the behavior of physiological systems and an organism's response to environmental change. Each mathematical model is an internally self-consistent summary of available information, and thereby defines a "working hypothesis" about how a system operates. Predictions from such models are subject to test, with new results leading to new models. The behavior of complex biological systems will be gradually revealed through this step-by-step process of building upon and further refining "what is known."
The Physiome Project Provides:
Databasing of information:
genome, proteome, morphome,
functional behavior of molecules and biological systems,
observations of intact cellular systems, organs, and intact organisms.
Integration and consilience of knowledge:
schema of interactions (descriptive models),
quantitative descriptions of relationship (casual, statistical, mechanistic),
computer models of small and large systems,
parameter sets for different cells, tissues, and species.
Network access to databases and models:
platform-independent networked search engines,
platform-independent web operation of models,
access to databases from descriptive and computational models.
National Center for Research Resources (NCRR) 1981-2003.
National Institute of Biomedical Imaging and Bioengineering (NIBIB) 2003-present.
Paul Yaeger, Chair, Department of Bioengineering,
University of Wisconsin
|Administering College/School:||College of Engineering|
|P.I. Home Department:||Department of Bioengineering|