This P30 Cystic Fibrosis (CF) Research and Translational Core Center (CFRTC) is located at the University of Washington School of Medicine (UWSOM) and its affiliated institution, Seattle Children’s Research Institute (SCRI). This center program enhances an existing robust basic and clinical research base at these institutions totaling over $20 million direct costs in external NIH and Cystic Fibrosis Foundation funding. The research for this P30 focuses on four emphasis areas:
1) provide resources and expertise to expedite promising new therapeutic approaches to correct absent or dysfunctional CFTR and its secondary consequences
2) foster sharing of existing and expanding human and bacterial biorepositories to enhance development of new biomarkers and laboratory assays
3) enhance understanding of bacterial pathogenesis in CF lung disease
4) enhance understanding of host inflammatory response and its secondary consequences in CF.
The center is led by co-PI’s, Dr. Bonnie Ramsey and Dr. E. Peter Greenberg, CF investigators both nationally recognized in their respective areas of clinical research and bacterial pathogenesis. The center consists of an Administrative Core (Ramsey and Greenberg) and four biomedical cores, Microbiology (Greenberg, Director), Genomics (Samuel Miller, Director), Inflammation (Charles Frevert, Director) and Clinical Translational (Christopher Goss and Ramsey, Directors). The centers also operates a Pilot and Feasibility (P&F) program led by Drs. Colin Manoil, a bacterial geneticist, and Ronald Gibson, a CF clinical investigator. Three P&F projects are funded every 2 years. The core center focuses on development of several novel therapeutic approaches to improve overall health for patients with CF.
Microbiology Core (http://depts.washington.edu/cfrtc/microbiology-people.php)
Genomics Core (http://depts.washington.edu/cfrtc/genomics-people.php)
Inflammation Core (http://depts.washington.edu/cfrtc/inflammation-people.php)
Clinical Core (http://depts.washington.edu/cfrtc/clinical-people.php)
NIH P30 DK089507, 2010-2015
Program Directors: Bonnie W. Ramsey, MD and E. Peter Greenberg, PhD
School of Medicine, Departments of Microbiology, Pediatrics, Genome Sciences, Comparative Medicine, Pathology, Immunology and Medicine (Division of Pulmonary and Critical Care Medicine)
Seattle Children's Research Institute