This National Institute on Drug Abuse (NIDA) P30 Center supplies the resources needed to apply cutting-edge genomic, proteomic, and bioinformatic technologies to the study of hepatitis C virus (HCV) infection and AIDS, chronic viral infections that are a direct consequence of drug abuse and addiction. We work with a variety of biologic resources, including serial liver biopsies from patients with recurrent HCV after liver transplantation, biopsies from patients co-infected with HCV and HIV-1, and experimental systems for HCV infection such as the SCID-beige/Alb-uPA chimeric mouse model and the HCV 2a in vitro infection system
The complex and heterogeneous data generated by our genomic and proteomic investigations is organized and maintained in local databases for analysis and knowledge discovery. Ongoing software development is aimed at providing the tools to integrate these diverse types of data and to develop quantitative and predictive models. Our unifying theme is to integrate the use of these technologies to develop a detailed understanding of the host response to virus infection and the molecular mechanisms underlying the progression of HCV-associated liver disease, AIDS, and HCV/HIV-1 dual infection.
|Director:||Katze, Michael G|
|Administering College/School:||School of Medicine|
|P.I. Home Department:||Department of Microbiology|