Department of Comparative Medicine

Current and former resident and trainee publications:

2010   2011   2012   2013   2014   2015   2016   2017


Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity. Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L. J Histochem Cytochem. 2017 Nov 1:22155417740880. doi: 10.1369/0022155417740880. [Epub ahead of print] PubMed PMID: 29290139.

Tumor Regulation of Lymph Node Lymphatic Sinus Growth and Lymph Flow in Mice and in Humans. Habenicht LM, Kirschbaum SB, Furuya M, Harrell MI, Ruddell A.  Yale J Biol Med. 2017 Sep 25;90(3):403-415. eCollection 2017 Sep. Review. PubMed PMID: 28955180; PubMed Central PMCID: PMC5612184.

Spontaneous loss of B lineage transcription factors leads to pre-B leukemia in Ebf1+/-Bcl-xLTg mice. Ramírez-Komo JA, Delaney MA, Straign D, Lukin K, Tsang M, Iritani BM, Hagman J. Oncogenesis. 2017 Jul 10;6(7):e355. doi: 10.1038/oncsis.2017.55.PMID: 28692033

Control of B lymphocyte development and functions by the mTOR signaling pathways. Iwata TN, Ramírez-Komo JA, Park H, and Iritani BM. Cytokine Growth Factor Rev. 2017 Jun;35:47-62. doi: 10.1016/j.cytogfr.2017.04.005. Epub 2017 May 22. Review. PMID: 28583723

Cardiotoxicity occurred in aged C57BL/6nia mice given a formulation containing poloxamer 407 hydrogel. Iwata T, Morton J, Snyder J, Ge X.  Pathobiol Aging Age Relat Dis. 2017 Mar 30;7(1):1304004. doi: 10.1080/20010001.2017.1304004. eCollection 2017. PubMed PMID: 28515860; PubMed Central PMCID: PMC54213

A Dynamic Anesthesia System for Long-Term Imaging in Adult Zebrafish. Zebrafish. Wynd BM, Watson CJ, Patil K, Sanders GE, Kwon RY. 2017 Feb;14(1):1-7. doi:10.1089/zeb.2016.1289. Epub 2016 Jul 13. PubMed PMID: 27409411; PubMed CentralPMCID: PMC5312524.


Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo. Li Y, Choi WJ, Qin W, Baran U, Habenicht LM, Wang RK.  J Neurosci Methods. 2016 Dec 1;274:164-171. doi: 10.1016/j.jneumeth.2016.10.010. Epub 2016 Oct 14. PubMed PMID: 27751893; PubMed Central PMCID: PMC5116418.

Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism. Iwata TN, Ramírez JA, Tsang M, Park H, Margineantu DH, Hockenbery DM, and Iritani BM. J Immunol. 2016 Sep 15;197(6):2250-60. doi: 10.4049/jimmunol.1600492. Epub 2016 Aug 12. PMID:27521345

Pauci-immune glomerulonephritis in a captive chimpanzee (Pan troglodytes), and a review of spontaneous cases in animals. Neidig LE, Owston MA, Ball E, Dick EJ Jr.  J Med Primatol. 2016 Dec;45(6):336-341. doi: 10.1111/jmp.12233. Epub 2016 Aug 10. Review. PubMed PMID: 27506330; PubMed Central PMCID: PMC5303195.

Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy. Habenicht LM, Albershardt TC, Iritani BM, and Ruddell A. Oncoimmunology. 2016 Jun 30;5(8):e1204505. doi: 10.1080/2162402X.2016.1204505

Effects of Murine Norovirus on Chlamydia pneumoniae-Accelerated Atherosclerosis in ApoE(-/-) Mice. Patil K, Campbell LA, Rosenfeld ME, Paik J, Brabb T, O’brien KD, Maggio-Price L, Hsu CC. Comp Med. 2016;66(3):188-96.

Immunocompromised mice-the backbone of PDX Models. Chapter 4 In: Patient Derived Tumor Xenograft Models, Elsevier press (2016) Hirenuller-S, Dinesh, Julita A. Ramirez, and Brian M. Iritani

Histologic Lesions Induced by Murine Norovirus Infection in Laboratory Mice.  Hsu CC, Piotrowski SL, Meeker SM, Smith KD, Maggio-Price L, Treuting PM. Vet Pathol. 2016 Jul;53(4):754-63. doi: 10.1177/0300985815618439. Epub 2016 Jan 20. Review. PMID:26792844

What Is Your Neurologic Diagnosis? Myelopathy in the region of T3 through L2. Meeker SM, Treuting PM, Maggio-Price L, Snyder JM. J Am Vet Med Assoc. 2016 Apr 15;248(8):883-5. doi: 10.2460/javma.248.8.883. No abstract available.  PMID:27031412

Protective links between vitamin D, inflammatory bowel disease and colon cancer. Meeker S, Seamons A, Maggio-Price L, Paik J. World J Gastroenterol. 2016 Jan 21;22(3):933-48. doi: 10.3748/wjg.v22.i3.933. Review. PMID:26811638


Correlation of Versican Expression, Accumulation, and Degradation during Embryonic Development by Quantitative Immunohistochemistry. Snyder JM, Washington IM, Birkland T, Chang MY, Frevert CW. J Histochem Cytochem. 2015 Dec;63(12):952-67. doi: 10.1369/0022155415610383. Epub 2015 Sep 18.PMID:26385570

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven

Autoimmunity and Multi-organ Development. Pestal K, Funk CC, Snyder JM, Price ND, Treuting PM, Stetson DB.  Immunity. 2015 Nov 17;43(5):933-44. doi: 10.1016/j.immuni.2015.11.001. PubMed PMID: 26588779; PubMed Central PMCID: PMC4654992.

Isolation of segmented filamentous bacteria from complex gut microbiota. Ericsson AC, Turner G, Montoya L, Wolfe A, Meeker S, Hsu C, Maggio-Price L, Franklin CL.Biotechniques. 2015 Aug 1;59(2):94-8. doi: 10.2144/000114319. eCollection 2015 Aug. PMID:26260088

Murine Norovirus Infection Variably Alters Atherosclerosis in Mice Lacking Apolipoprotein E.Hsu CC, Paik J, Brabb TL, O’Brien KD, Kim J, Sullivan BG, Hudkins KL, Seamons A, Finley JC, Meeker SM, Maggio-Price L. Comp Med. 2015 Oct;65(5):369-81. PMID:26473341

Potential for using a hermetically-sealed, positive-pressured isocage system for studies involving germ-free mice outside a  flexible-film isolator. Paik J, Pershutkina O, Meeker S, Yi JJ, Dowling S, Hsu C, Hajjar AM, Maggio-Price L, Beck DA.  Gut Microbes. 2015 Jul 4;6(4):255-65. doi: 10.1080/19490976.2015.1064576. Epub 2015 Jul 15. PubMed PMID: 26177210; PubMed Central PMCID: PMC4615381.

Hepatic Lipidosis in a Research Colony of Big Brown Bats (Eptesicus fuscus). Snyder JM, Treuting PM, Brabb T, Miller KE, Covey E, Lencioni KL.Comp Med. 2015 Apr;65(2):133-9. PubMed PMID: 25926399; PubMed Central PMCID: PMC4408899.

Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy. Reyes NL, Banks GB, Tsang M, Margineantu D, Gu H, Djukovic D, Chan J, Torres M, Liggitt HD, Hirenallur-S DK, Hockenbery DM, Raftery D, and Iritani BM. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):424-9. doi: 10.1073/pnas.1413021112. Epub 2014 Dec 29. PMID:25548157


Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis  in C57BL/6 mice. Snyder JM, Treuting PM, Nagy L, Yam C, Yi J, Brasfield A, Nguyen LP, Hajjar AM.  PLoS One. 2014 Sep 17;9(9):e107257. doi: 10.1371/journal.pone.0107257. eCollection 2014. PubMed PMID: 25229618; PubMed Central PMCID: PMC4168129.

Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer. Meeker S, Seamons A, Paik J, Treuting PM, Brabb T, Grady WM, Maggio-Price L. Cancer Res. 2014 Aug 15;74(16):4398-408. doi: 10.1158/0008-5472.CAN-13-2820. Epub 2014 Jun 17. PMID: 24938764

Infection with murine norovirus 4 does not alter Helicobacter-induced inflammatory bowel disease in Il10(-/-) mice. Hsu CC, Paik J, Treuting PM, Seamons A, Meeker SM, Brabb TL, Maggio-Price L. Comp Med. 2014 Aug;64(4):256-63.

Pathology in practice. Adenocarcinoma of the proventriculus with liver metastasis and marked, diffuse chronic-active proventriculitis and ventriculitis with moderate M. ornithogaster infection in a  budgerigar. Snyder JM, Treuting PM. J Am Vet Med Assoc. 2014 Mar 15;244(6):667-9. doi: 10.2460/javma.244.6.667. PubMed PMID: 24568107.

ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.  Jones CJ, Newsom D, Kelly B, Irie Y, Jennings LK, Xu B, Limoli DH, Harrison JJ, Parsek MR, White P, Wozniak DJ.  PLoS Pathog. 2014 Mar 6;10(3):e1003984. doi: 10.1371/journal.ppat.1003984. eCollection 2014 Mar. PubMed PMID: 24603766; PubMed Central PMCID: PMC3946381.

Gyrodactylid ectoparasites in a population of rainbow trout (Oncorhynchus mykiss). Garcia RL, Hansen AG, Chan MM, Sanders GE.  J Am Assoc Lab Anim Sci. 2014  Jan;53(1):92-7. PubMed PMID: 24411786; PubMed Central PMCID: PMC3894654.


Sanitization of an automatic reverse-osmosis watering system: removal of a clinically significant biofilm. Molk DM, Karr-May CL, Trang ED, Sanders GE.  J Am Assoc Lab Anim Sci. 2013 Mar;52(2):197-205. PubMed PMID: 23562105; PubMed Central PMCID: PMC3624790.

Hematopoietic protein-1 regulates the actin membrane skeleton and membrane stability in murine erythrocytes. Chan MM, Wooden JM, Tsang M, Gilligan DM, Hirenallur-S DK, Finney GL, Rynes E, Maccoss M, Ramirez JA, Park H, Iritani BM.  PLoS One.  2013;8(2):e54902. doi: 10.1371/journal.pone.0054902. Epub 2013 Feb 12. PubMed PMID: 23424621; PubMed Central PMCID: PMC3570531.

Increased mortality in a colony of zebra finches exposed to continuous light. Snyder JM, Molk DM, Treuting PM. J Am Assoc Lab Anim Sci. 2013;52(3):301-7. PubMed PMID: 23849414; PubMed Central PMCID: PMC3690453.

Clean technique for prolonged nonsurvival cardiothoracic surgery in swine (Sus scrofa). Chan MM, Rabkin DG, Washington IM.  J Am Assoc Lab Anim Sci. 2013 Jan;52(1):63-9. PubMed PMID: 23562035; PubMed Central PMCID: PMC3548203.


5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Hagan CE, McDevitt RA, Liu Y, Furay AR, Neumaier JF.  Synapse. 2012 Dec;66(12):1024-34. doi: 10.1002/syn.21608. Epub 2012 Sep 29. PubMed PMID: 22961814; PubMed Central PMCID: PMC3472085.


BB rat Gimap gene expression in sorted lymphoid T and B cells. Moralejo DH, Fuller JM, Rutledge EA, Van Yserloo B, Ettinger RA, Jensen R, Osborne W, Kwitek A, Lernmark A.  Life Sci. 2011 Nov 7;89(19-20):748-54. doi: 10.1016/j.lfs.2011.08.016. Epub 2011 Sep 10. PubMed PMID: 21925515; PubMed Central PMCID: PMC3264544.

Cytokine antibody array analysis in brain and periphery of scrapie-infected Tg338 mice. Newsom DM, Liggitt HD, O’Rourke K, Zhuang D, Schneider DA, Harrington RD. Comp Immunol Microbiol Infect Dis. 2011 Sep;34(5):387-97. doi: 10.1016/j.cimid.2011.06.001. Epub 2011 Jul 23. PubMed PMID: 21788075.

The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes. Hagan CE, Schenk JO, Neumaier JF.  Synapse. 2011 Oct;65(10):1015-23. doi: 10.1002/syn.20929. Epub 2011 Apr 7. PubMed PMID: 21437992; PubMed Central PMCID: PMC3149756.

Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats. Moralejo D, Yanay O, Kernan K, Bailey A, Lernmark A, Osborne W.  J Biosci Bioeng. 2011 Apr;111(4):383-7. doi: 10.1016/j.jbiosc.2010.12.008. Epub 2011 Jan 8. PubMed PMID: 21216666; PubMed Central PMCID: PMC3074004.

Primary hepatic Mycobacterium tuberculosis complex infection with terminal dissemination in a pig-tailed macaque (Macaca nemestrina). Stockinger DE, Roellich KM, Vogel KW, Eiffert KL, Torrence AE, Prentice JL, Stephens KG, Wallis CK, Hotchkiss CE, Murnane RD.  J Am Assoc Lab Anim Sci. 2011 Mar;50(2):258-62. PubMed PMID: 21439222; PubMed Central PMCID: PMC3061429.


Hem-1: putting the “WAVE” into actin polymerization during an immune response. Park H, Chan MM, Iritani BM.  FEBS Lett. 2010 Dec 15;584(24):4923-32. doi: 10.1016/j.febslet.2010.10.018. Epub 2010 Oct 20. Review. PubMed PMID: 20969869; PubMed Central PMCID: PMC3363972.

Rotating disk electrode voltammetric measurements of serotonin transporter kinetics in synaptosomes. Hagan CE, Neumaier JF, Schenk JO.  J Neurosci Methods. 2010 Oct 30;193(1):29-38. doi: 10.1016/j.jneumeth.2010.08.009. Epub 2010 Aug 14. PubMed PMID: 20713085; PubMed Central PMCID: PMC2952731.

Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1. Yanay O, Moralejo D, Kernan K, Brzezinski M, Fuller JM, Barton RW, Lernmark A, Osborne WR.  J Gene Med. 2010 Jun;12(6):538-44. doi: 10.1002/jgm.1466. PubMed PMID: 20527046; PubMed Central PMCID: PMC2882674.

Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. Moralejo DH, Hansen CT, Treuting P, Hessner MJ, Fuller JM, Van Yserloo B, Jensen R, Osborne W, Kwitek AE, Lernmark A.  Physiol Genomics. 2010 Mar 3;41(1):9-20. doi: 10.1152/physiolgenomics.00186.2009. Epub 2009 Dec 8. PubMed PMID: 19996157; PubMed Central PMCID: PMC2841494.