Julie Mathieu
Associate Professor, Director, Ellison Stem Cell Core, Institute for Stem Cell and Regenerative Medicine, and Co-director, UW mouse CRISPR Core
PhD, University of Paris XI 2007
P: 206-221-6449
E: jmathieu@uw.edu
Institute for Stem Cell and Regenerative Medicine, UW Medicine at SLU
N501A, 850 Republican street, Seattle WA 98109
Research, Service, and Training Interests
Dr. Mathieu’s research centers on elucidating the cellular and molecular mechanisms that govern cell fate decisions in both normal and pathological context, with a special focus on the interplay between metabolism and epigenetics in development and disease. Her primary objective is to uncover the key factors that influence cell fate under healthy and diseased conditions. She utilizes pluripotent stem cell technologies combined with genome editing to generate disease models in vitro, enabling her to investigate disease progression and explore potential therapeutic strategies.
Dr. Mathieu is the director of the Ellison Stem Cell core at the Institute for Stem Cell and Regenerative Medicine (ISCRM). By providing training, support and genome editing services, the Ellison Stem Cell core assists investigators with their research in basic biology, disease modeling and regenerative medicine. The core has successfully edited the genome of various species, including human, non-human primate and mouse. Dr. Mathieu is co-director of the UW mouse CRISPR core which offers full-service genome editing to the Seattle community through the Transgenic Resources Program and the Department of Comparative Medicine.
Selected Publications
Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States. Battle SL, Doni Jayavelu N, Azad RN, Hesson J, Ahmed FN, Overbey EG, Zoller JA, Mathieu J, Ruohola-Baker H, Ware CB, Hawkins RD. Stem Cell Reports. 2019. 12(5):1129-1144.
Suppression of unwanted CRISPR/Cas9 editing by co-administration of catalytically inactivating, truncated guide RNAs. Rose JC, Popp NA, Richardson CD, Stephany JJ, Mathieu J, Wei CT, Corn JE, Maly DJ, and Fowler DM. BioRxiv. 2019
Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma. Siebenthall KT, Miller CP, Vierstra JD, Mathieu J, Tretiakova M, Reynolds A, Sandstrom R, Rynes E, Haugen E, Johnson A, Nelson J, Bates D, Diegel M, Dunn D, Frerker M, Buckley M, Kaul R, Zheng Y, Himmelfarb J, Ruohola-Baker H, Akilesh S. EBioMedicine. 2019. 41:427-442.
Metabolism as an early predictor of DPSCs aging. Macrin D, Alghadeer A, Zhao YT, Miklas J, Hussein A, Detraux D, Robitaille A, Madan A, Moon RT, Wang Y, Devi A, Mathieu J and Ruohola-Baker H. Scientific Reports. 2019. 9(1):2195.
Inducible CRISPR genome editing platform in naive human embryonic stem cells. Ferreccio A*, Mathieu J*, Detraux D, Logeshwaran S, Cavanaugh C, Sopher B, Fischer KA, Bello T, Hussein AM, Levy S, Cook S, Sidhu S, Palpant NJ, Reinecke H, Wang Y, Paddison P, Murry C, Jayadev S, Ware CB and Ruohola-Baker H. Cell Cycle. 2018. 17(5):535-549. * Equal contribution