Department of Comparative Medicine

Carol B. Ware


Ph.D., University College Dublin 1986

P: 206-616-5143

About Dr. Ware

Dr. Ware’s Ph.D. training was in the animal sciences focused on reproductive endocrinology and embryology.  She has been studying inner cell mass derived pluripotent stem cells since 1988.  Currently, her primary research involves pluripotent stem cells through understanding the stages encompassing mammalian pluripotency.  As such, she is the Director of the Ellison Stem Cell Core of the Institute for Stem Cell and Regenerative Medicine (ISCRM) at South Lake Union.  Teaching responsibilities include CONJ 530, Directing Stem Cells Toward Regenerative Medicine and organization of ISCRM seminar series.  She serves on several Ph.D. candidate committees and is a member of the Department of Oral Health Sciences Graduate Fellowship Committee. She is an Adjunct Professor in the UW Dept. of Oral Health Sciences.

Completed list of publications

Selected publications out of 75

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death Ware, CB, Horowitz, MC, Renshaw, BR, Hunt, JS, Liggitt, D, Koblar, SA, Gliniak, BC, McKenna, HJ, Papayannopoulou, T, Thoma, B, Donovan, PJ, Peschon, JJ, Bartlett, PF, Willis, CR, Wright, BD, Carpenter, MK, Davison, BL and Gearing DP, Development, 1995 May;121(5):1283-99 PMID: 7789261

Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells.  Ware CB, Wang L, Mecham BH, Forough R, Nelson AM, Dauphin DS, Buckingham B, Bar M, Lim R, Askari B, Gartler SM, Shen L, Issa J-P, Tewari M, Lamba DA, Pavlidis P, Duan Z and Blau CA. Cell Stem Cell. 2009 Apr 3; 4(4):359-369. doi: 10.1016/j.stem.2009.03.001. PMID: 19341625

Derivation of naïve human embryonic stem cells.  Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, Jonlin E, Jimenez-Caliani AJ, Deng X, Cavanaugh C, Cook S, Tesar PJ, Okada J, Margaretha L, Sperber H, Choi M, Blau CA, Treuting P, Hawkins RD, Cirulli V, Ruohola-Baker H.  Proc Natl Acad Sci. U S A 2014 Mar 25;111(12):4484-9. doi: 10.1073/pnas.13198738111. Epub 2014 Mar 12.  PMID: 24623855

Concise Review: Lessons from naïve human pluripotent cellsWare CB. Stem Cells. Epub 2016 Nov 10. Review. PMID: 27663171

Enhancer chromatin and 3D genome architecture changes from naive to primed human embryonic stem cell states  Battle SL, Jayavelu ND, Azad RN, Hesson J, Ahmed FN, Overbey EG, Zoller JA, Mathieu J, Ruohola-Baker H, Ware CB, Hawkins RD,    Stem Cell Reports, 2019 May 14;12(5):1129-1144. doi: 10.1016/j.stemcr.2019.04.004. Epub 2019 May 2 PMID: 31056477