Department of Comparative Medicine

Julie Mathieu

Assistant Professor, Director, Ellison Stem Cell Core, Institute for Stem Cell and Regenerative Medicine, and Co-director, UW mouse CRISPR Core

PhD, University of Paris XI 2007

P: 206-221-6449

Institute for Stem Cell and Regenerative Medicine, UW Medicine at SLU
S571, 850 Republican street, Seattle WA 98109

Research, Service, and Training Interests

Dr. Mathieu’s research focuses on the factors governing cell fate decision in normal and pathological conditions. Her main goal is to understand how cancer cells exploit some of the unique properties of stem cells, such as self-renewing capacities and reliance on glucose as a source of energy. Dr. Mathieu studies how cellular fate changes are regulated in early stages of human development, and uses these findings to better understand cancers and cancer stem cell formation.

Dr. Mathieu is the associate director of the Ellison Stem Cell core at the Institute for Stem Cell and Regenerative Medicine. By providing training, support and genome editing services, the Ellison Stem Cell core assists investigators with their research in basic biology, disease modeling and regenerative medicine. The core has successfully edited the genome of various species, including human, non-human primate and mouse. Dr. Mathieu is co-director of the UW mouse CRISPR core which offers full-service genome editing to the Seattle community through the Transgenic Resources Program and the Department of Comparative Medicine.

Selected Publications

Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States. Battle SL, Doni Jayavelu N, Azad RN, Hesson J, Ahmed FN, Overbey EG, Zoller JA, Mathieu J, Ruohola-Baker H, Ware CB, Hawkins RD. Stem Cell Reports. 2019. 12(5):1129-1144.

Suppression of unwanted CRISPR/Cas9 editing by co-administration of catalytically inactivating, truncated guide RNAs. Rose JC, Popp NA, Richardson CD, Stephany JJ, Mathieu J, Wei CT, Corn JE, Maly DJ, and Fowler DM. BioRxiv. 2019

Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma. Siebenthall KT, Miller CP, Vierstra JD, Mathieu J, Tretiakova M, Reynolds A, Sandstrom R, Rynes E, Haugen E, Johnson A, Nelson J, Bates D, Diegel M, Dunn D, Frerker M, Buckley M, Kaul R, Zheng Y, Himmelfarb J, Ruohola-Baker H, Akilesh S. EBioMedicine. 2019. 41:427-442.

Metabolism as an early predictor of DPSCs aging. Macrin D, Alghadeer A, Zhao YT, Miklas J, Hussein A, Detraux D, Robitaille A, Madan A, Moon RT, Wang Y, Devi A, Mathieu J and Ruohola-Baker H. Scientific Reports. 2019. 9(1):2195.

Inducible CRISPR genome editing platform in naive human embryonic stem cells. Ferreccio A*, Mathieu J*, Detraux D, Logeshwaran S, Cavanaugh C, Sopher B, Fischer KA, Bello T, Hussein AM, Levy S, Cook S, Sidhu S, Palpant NJ, Reinecke H, Wang Y, Paddison P, Murry C, Jayadev S, Ware CB and Ruohola-Baker H. Cell Cycle. 2018. 17(5):535-549. * Equal contribution