Department of Comparative Medicine

Jessica M. Snyder

Associate Professor

D.V.M., Virginia Maryland Regional College of Veterinary Medicine, 2001
M.S., University of Washington, 2014
Diplomate, ACVIM (Neurology), 2005
Diplomate, ACVP (Anatomic), 2015

1-446 Box 357340, Seattle, WA 98195

About Dr. Snyder

Dr. Snyder’s research broadly involves the assessment of pre-clinical animal models developed to address unmet translational needs of human diseases. As a comparative pathologist, her focus is the examination and validation of animal model phenotypes and evaluation of treatments and interventions via the application of clinicopathologic and histopathologic diagnostic criteria and scoring systems. Her specific interests include rodent models of aging and large and small animal models of neuromuscular and central nervous system disease. She also assists investigators with aspects of study design and data interpretation. Dr. Snyder is the Director of the Comparative Pathology Program. She coordinates CMED 514 and CMED 512 and is an instructor in pathology rounds and rotations offered by the Department of Comparative Medicine (CMED 590; JPC sessions).

Selected Publications:

  1. Canagliflozin Retards Age-Related Lesions in Heart, Kidney, Liver, and Adrenal Gland in Genetically Heterogenous Male Mice.  Snyder JM , Casey KM, Galecki A, Harrison DE, Jayarathne H, Kumar N, Macchiarini F, Rosenthal N, Sadagurski M, Salmon AB, Strong R, Miller RA,  Ladiges W. Geroscience 2022. PMID: 35974129.
  2. ADAR1 mutation causes ZBP1-dependent immunopathology. Hubbard NW, Ames JM, Maurano M, Chu LH, Somfleth KY, Gokhale NS, Werner M, Snyder JM, Lichauco K, Savan R, Stetson DB, Oberst A. Nature 2022; 607 (7920):769-775. PMID: 35859177.
  3. Perfusion with 10% neutral-buffered formalin is equivalent to 4% paraformaldehyde for histopathology and immunohistochemistry in a mouse model of experimental autoimmune encephalomyelitis. Snyder JM, Radaelli E, Goeken A, Businga T, Boyden AW, Karandikar NJ, Gibson-Corley KN.   Vet Pathol 2022;59(3):498-505. PMID: 35130806
  4. Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice. Snyder JM,* Zhong G,* Hogarth C,* Huang W, Topping T, LaFrance J, Palau L, Czuba LC, Griswold M, Ghiaur G, Isoherranen N. FASEB J 2020; 34(12):15788-15804. PMID: 33105029 *contributed equally to work
  5. Ontogeny of white matter, toll-like receptor expression, and motor skills in the neonatal ferret. Snyder JM,* Wood TR,* Corry K, Moralejo DH, Parikh P, Juul SE. Int J Dev Neurosci. 2018 Nov;70:25-33. doi: 10.1016/j.ijdevneu.2018.05.006. Epub 2018 May 20. *denotes authors contributed equally to work
  6. Systemic AAV8-mediated gene therapy drives whole-body correction of myotubular myopathy in dogs. Mack DL, Poulard K, Goddard M, Latournerie V, Snyder JM, Grange RW, Elverman MR, Denard J, Veron P, Buscara L, Le Bec C, Hogrel J, Doering J, Meng H, Yang L, Liu F, O’Callaghan M, Gopal N, Kelly VE, Smith BK, Strande JL, Mavilio F, Beggs AH, Mingozzi F, Lawlor MW, Buj-Bello A, and Childers MK. Mol Ther 25(4):839-854. doi: 10.1016/j.ymthe.2017.02.004, 2017.
  7. Cause-of-Death Analysis in Rodent Aging StudiesSnyder JM, Ward JM, Treuting PM.  Vet Pathol. 53(2):233-43. doi: 10.1177/0300985815610391, 2016.
  8. Correlation of Versican Expression, Accumulation, and Degradation during Embryonic Development by Quantitative ImmunohistochemistrySnyder JM, Washington IM, Birkland T, Chang MY, and Frevert CW.    J Histochem Cytochem 63(12):952-67. doi: 10.1369/0022155415610383, 2015.