Department of Comparative Medicine

Denny Liggitt


Professor Emeritus, DACVP

P: 206-685-3256

About Denny Liggitt

“My position as Chairman and Professor in the Department of Comparative Medicine (DCM), School of Medicine, University of Washington is oriented toward approximately 65% administrative, 15% service/teaching, 20% research. Teaching responsibilities are confined to formal seminar contacts and graduate student/post-doc/resident interactions. I am a board-certified veterinary pathologist with expertise in rodent pathology. Research interests are principally collaborative and directed toward projects involving, in a broad sense species and strain related variations, in-vivo interactions of the host with its defense and steady-state mechanisms and the role that selected cytokines and growth factors play in this interaction. I also have experience in the development and approval process for biologic and gene-based therapeutics hence some research and advisory efforts involve translational research with a pre-clinical emphasis.”

Selected Publications

Skerrett, S.J., Liggitt, H.D., Hajjar, A.M., Wilson, C.B. Myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J. Immunol. 172:3377-3381, 2004.

Xu, R., Johnson, A.J., Liggitt, D., Bevan, M.J.  Cellular and humoral immunity against vaccina virus infection of mice.  J. Immunol 172:6265-6271, 2004.

Fong, S., Liu, Y., Heath, T., Fong, P., Liggitt, D., Debs, R.  Membrane permeant, DNA-binding agents target complexed plasmid DNA directly into the nucleus.  Molecular Therapy 10:706-718, 2004.

Dow, S., Elmslie, R., Kurzman, I., Macewen, G., Pericle, F., Liggitt, D.  Phase 1 study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases.  Hum Gene Ther 16:937-46, 2005.

Kharasch, E.D., Schroeder, J.L., Sheffels, P., Liggitt, H.D.  Influence of sevoflurane on the metabolism and renal effects of compound A in rats.  Anesthesiology 103:1183-1188, 2005.

Marie, JC, Liggitt, D, Rudensky, AY. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T-cell specific targeting of tgf-beta receptor. Immunity 25:441-54, 2006.

Liu, Y, Liggitt, D, Fong, S, Debs, RJ.  Systemic co-administration of depsipeptide selectively targets transfection enhancement to specific tissues and cell types. Gene Therapy 13:1724-30, 2006.

Cabbage, S.E., Huseby, E.S., Sather, B.D., Brabb, T., Liggitt, D., Goverman, J.  Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance.  J. Immunol. I178:887-96, 2007.

Harrington, R.D., Baszler, T.V., O’Rourke, K.I., Schneider, D.A., Spraker, T.R., Liggitt, H.D., Knowles, D.P. A species barrier limits transmission of chronic wasting disease to mink (Mustela vison). J Gen Virol 89(pt4):1086-96 , 2008.

Langdale, L.A. ,Hoagland, V.,  Benz, W.,  Riehle, K, J.,  Campbell, J.S. Liggitt, D., Fausto, N. Suppressor of Cytokine Signaling Expression with Increasing Severity of Murine Hepatic Ischemia-Reperfusion Injury  Hepatology 49(2): 198-206, 2008

Gregorevic P, Schultz BR, Blankinship MJ, Meznarich NAK, Doremus C, Finn E, Allen JM, Kuhr CS, Haldorson JB, Liggitt, HD, Chamberlain JS. Evaluation of methodologies to enhance rAAV6-mediated gene transfer to canine musculature.  Molecular Therapy 17:1427-1433, 2009.

Morris AE, Liggitt HD, Hawn TR, Skerret SJ.  The role of toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia.  Am J Physiol Lung Cell Mol Physiol. 297(6): L1112-9, 2009.