Department of Comparative Medicine

Brian M. Iritani, D.V.M., Ph.D.

Professor

D.V.M., Washington State University 1988
Ph.D., Immunology, University of Washington 1997
Clinical Residency, Lab Animal Medicine, University of Washington 1996
Research Post-doctoral Fellow, Fred Hutchinson Cancer Research Center 1999

P: 206-221-3932
F: 206-685-3006
E: biritani@uw.edu

Research, Service, and Training Interests

Dr. Iritani joined the Faculty in Comparative Medicine in 1999.  His major clinical interests include small animal medicine and surgery.  He is currently a Senior Clinical Veterinarian, Director of Surgery, Co-Director of Training Programs, Director of Clerkship Training for Veterinary Students.  He is a member of the Fred Hutchinson Cancer Research Center Consortium, Nutrition and Obesity Research Center (NORC), Diabetes and Endocrine Research Center (DERC), Solid tumor and translational research team (STTR), Molecular and Cellular Biology  (MCB) Graduate Program, Initiative for Maximizing Student Diversity (IMSD).  Dr. Iritani serves on numerous NIH Study Sections in Basic Immunology and is on the Editorial Review Boards for Comparative Medicine and JAALAS.

The Iritani lab studies the normal functions of oncoproteins and other signaling molecules in the development and function of immune cells, and how when dysregulated, aberrant expression or activity can result in immunodeficiency diseases or cancer.  Among the oncoproteins the Iritani lab studies include the Ras GTPases, Raf kinase, and the Myc family of transcriptional regulators. More recently the Iritani lab has become interested in the metabolic control of lymphocyte development by the Folliculin Interacting Proteins (Fnip1 and Fnip2), and the regulation of immune cell functions by Hematopoietic Protein-1 (Hem1) and the actin cytoskeleton.

Complete Bibliography

Selected Publications

Myc Stimulates B Cell Development and Amplifies Calcium Signaling.
Habib, T., Park, H., Tsang, M., de Alboran, I., Nicks, A., Wilson, L., Knoepfler, P., Andrews, S., Rawlings., D., Eisenman, R.N., and  Iritani, B.M.  (2007) The Journal of Cell Biology, 179(4)717-731.

A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity.
Park,H., Staehling-Hampton, K., Brunkow, M.E., Habib, T., Appleby, M., Zhang,Y., Ramsdell, F., Freie, B., Tsang, M., Liggitt, H.D., Carlson, G., Frevert, C., and B.M. Iritani (2008). The Journal of Experimental Medicine, 205(12)2899-913.

Disruption of Fnip1 reveals a novel metabolic checkpoint controlling B lymphocyte development.
Park, H., Staehling-Hampton, K., Tsang, M., Appleby, M., Brunkow, M.E., Margineantu, D., Hockenbery, D.M., Habib, T., Liggitt, H.D., Carlson, G., and B.M. Iritani (2012). Immunity, May 25;36(5):769-81. Epub 2012 May 17.

Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy.
Reyes, NL., Banks, GL., Tsang, M., Margineantu, D., Gu, H., Djokovic, D., Chan, J., Torres, M., Liggitt, HD., Hirenallur-S., DK., Hockenbery, DM., Raftery, D., and B.M. Iritani (2015). Proceedings of the National Academy of Sciences, Jan 13;112(2):424-9.

Conditional disruption of Raptor reveals an essential role for mTOR in B cell development, survival, and metabolism.
Iwata, T., Ramirez, J., Tsang, M., Park, H., Margineantu, D., Hockenbery, D.M., and B.M. Iritani. (2016) Journal of Immunology, online August 12, 2016.