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Four University of Washington professors were among the winners of the 2021 Breakthrough Prize, which recognizes groundbreaking achievements in the life sciences, fundamental physics and mathematics.

David Baker, a professor in the UW School of Medicine’s department of biochemistry, won the prize for life sciences, while a team of UW physics professors, including Eric Adelberger, Jens Gundlach and Blayne Heckel, earned the prize for fundamental physics.

A team of scientists at the University of Washington and the biotechnology company Illumina have created an innovative tool to directly detect the delicate, single-molecule interactions between DNA and enzymatic proteins. Their approach provides a new platform to view and record these nanoscale interactions in real time. As they report Sept. 28 in Nature Biotechnology, this tool should provide fast and reliable characterization of the different mechanisms cellular proteins use to bind to DNA strands — information that could shed new light on the atomic-scale interactions within our cells and help design new drug therapies against pathogens by targeting enzymes that interact with DNA.