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Come curious. Leave inspired. While February might be just 28 days, the UW offers an exciting lineup of more than 40 in-person and online events. From thought-provoking art and music to conversations on culture, history, and science, the UW community invites you to explore, learn, and connect across disciplines throughout the University. And you don’t have to wait until February—take a look at everything still happening this January. In addition, sign up to receive a monthly notice when the ArtSci Roundup…

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint precise areas of the body can reduce the medicine dosage and avoid potentially harmful “off target” effects. Researchers at the UW took a significant step toward that goal by designing proteins with autonomous decision-making capabilities. By adding smart tail structures to therapeutic proteins, the team demonstrated that the proteins could be “programmed” to act based on the presence of specific environmental cues.

Three University of Washington faculty members have been awarded early-career fellowships from the Alfred P. Sloan Foundation. The new Sloan Fellows, announced Feb. 18, are Amy L. Orsborn, the Clare Boothe Luce assistant professor of electrical & computer engineering and bioengineering, Dianne J. Xiao, an assistant professor of chemistry in the College of Arts & Sciences, and Amy X. Zhang, an assistant professor of computer science in the Paul G. Allen School of Computer Science & Engineering. 

Fifteen faculty members at the University of Washington have been elected to the Washington State Academy of Sciences for 2024. They are among 36 scientists and educators from across the state announced Aug. 1 as new members. Selection recognizes the new members’ “outstanding record of scientific and technical achievement, and their willingness to work on behalf of the academy to bring the best available science to bear on issues within the state of Washington.”

New research led by the UW demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.

A University of Washington Video production, “Brainworks: Vision and the Brain,” won a 2023 Northwest Emmy Award this month in the Children/Youth/Teens category. “Brainworks” is a series that educates children about neuroscience. The episode was executive produced by Eric H. Chudler, research associate professor of bioengineering and executive director of the UW Center for Neurotechnology, and Cara Podenski, managing executive producer for UW Video. Podenski also wrote and directed. Dave Ris served as an editor. “Vision and the Brain,” hosted by Chudler, guides viewers through the…

Researchers at the University of Washington have detected “toxic” small aggregates of a particular protein in the blood of individuals with Alzheimer’s disease, as well as in individuals who showed no signs of cognitive impairment at the time the blood sample was taken, but who developed it at a later date. This blood test picks up oligomers — or small, misfolded aggregates — of the amyloid beta protein, which scientists believe triggers the development of Alzheimer’s.

University of Washington Professor Joan Sanders and her team are creating a new type of prosthetic leg: one that automatically adjusts its fit throughout the day. Their latest prototype detects in real time how well the prosthesis socket and amputation site are fitting and responds by automatically changing the size of the socket, without the need for adjustments to padding or user action.

Researchers at the University of Washington have developed a new test for COVID-19 that combines the speed of over-the-counter antigen tests with the accuracy of PCR tests that are processed in medical labs and hospitals. The Harmony COVID-19 test is a diagnostic test that, like PCR tests for COVID-19, detects genetic material from the SARS-CoV-2 virus. But whereas conventional PCR tests can take several hours, the Harmony kit can provide results in less than 20 minutes for some samples and with similar accuracy.

A team led by the UW has developed a new, non-destructive method that images entire 3D biopsies instead of a slice for determining prostate cancer aggressiveness. The 3D images provided more information than a 2D image — specifically, details about the tree-like structure of the glands throughout the tissue.

On Sept. 28, the National Science Foundation announced $15 million, five-year grant to integrate AI tools into the scientific research and discovery process. The award will fund the Accelerated AI Algorithms for Data-Driven Discovery Institute — or A3D3 Institute — a partnership of nine universities, led by the University of Washington.

Researchers at the University of Washington have developed a method that uses smartphone-derived images to reveal potentially harmful bacteria on skin and in oral cavities. Their approach can visually identify microbes on skin contributing to acne and slow wound healing, as well as bacteria in the oral cavity that can cause gingivitis and dental plaques.

The potted junipers on the steps of Suzzallo Library are undergoing a transformation. Flanking the entrance to one of UW’s most beloved buildings, they are viewed by hundreds of people walking through Red Square each week. Bioengineering postdoctoral researcher Le Zhen is transforming these shrubs into bonsai — miniature trees that are pruned, nurtured and trained with wire to look like their much older, full-sized counterparts living in nature. He hopes this prominent display of bonsai will signal to members of the AAPI community that UW is safe and welcoming.

Researchers at the University of Washington have developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages that affect cell behavior. Their approach, published the week of Jan. 18 in the Proceedings of the National Academy of Sciences, uses a near-infrared laser to trigger chemical adhesion of protein messages to a scaffold made from biological polymers such as collagen, a connective tissue found throughout our bodies.

Recent honors to UW faculty and staff members include awards for architectural education and biomaterials research, fellowships in nursing and cloud computing, a professor named among Seattle’s most influential people and a big news year for “a burgeoning band of embodied carbon busters.”

Scientists have discovered that the building blocks of proteins can stabilize cell membranes. This finding may explain how the first cells emerged from the primordial soup billions of years ago: The protein building blocks could have stabilized cell membranes against salt and ions that were present in ancient oceans. In addition, membranes may have been a site for these precursor molecules to co-localize, a potential mechanism to explain what brought together the ingredients for life.

In a paper published May 20 in the journal Nature Materials, a team of researchers from the University of Washington unveiled a new strategy to keep proteins intact and functional in synthetic biomaterials for tissue engineering. Their approach modifies proteins at a specific point so that they can be chemically tethered to the scaffold using light. Since the tether can also be cut by laser light, this method can create evolving patterns of signal proteins throughout a biomaterial scaffold to grow tissues made up of different types of cells.

The NIH has awarded a $6.5 million, five-year grant to the University of Washington and partner institutions to establish the Center for Reproducible Biomedical Modeling. The center’s primary goal is to develop more effective predictive models of biological systems, which are used in research and medicine.

Researchers at the University of Washington and the Allen Institute for Brain Science have developed a new method to classify and track the multitude of cells in a tissue sample. In a paper published March 15 in the journal Science, the team reports that this new approach — known as SPLiT-seq — reliably tracks gene activity in a tissue down to the level of single cells.

Scientists at the University of Washington have discovered a simple way to raise the accuracy of diagnostic tests for medicine and common assays for laboratory research. By adding polydopamine — a material that was first isolated from shellfish — to these tests at a key step, the team could increase the sensitivity of these common bioassays by as many as 100 to 1,000 times.

For the first time in humans, UW Center for Sensorimotor Neural Engineering (CSNE) researchers have used direct stimulation of the human brain surface to provide basic sensory feedback through artificial electrical signals, enabling patients to control movement while opening and closing their hand.

Researchers at the University of Washington are among the winners of a startup challenge to shorten the transition time from lab bench to patient. The team, including members of professor Suzie Pun’s research group in the UW Department of Bioengineering, was selected based on its proposal and business plan to develop a targeted drug delivery system for breast cancer.

In December, the University of Washington’s Department of Bioengineering began accepting applications for its newest graduate degree program, the Master of Applied Bioengineering. The one-year, full-time program begins in August, and will train students to apply engineering design and entrepreneurship skills to address unmet clinical needs and to transform biomedical research into technologies for improving health care. The degree will position graduates to respond to market-based demands of industry, medicine and translational research.

Three scientists at the University of Washington have proposed a way to speed up common bioassays used in research and diagnostics. Their solution, reminiscent of the magic behind washing machines, could reduce wait times to a fraction of what they once were. As they report in the journal Small, biological assays that once took hours could instead take minutes.