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Category: Biomedical Research

Proposed Uniform Guidance Changes

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On May 29, 2026, the federal Office of Management and Budget (OMB) published a proposed rule in the Federal Register that would substantially revise 2 C.F.R. Part 200, commonly referred to as the “Uniform Guidance”, which applies to federal grants, cooperative agreements and other types of federal assistance funding.

If finalized, the proposed rule would significantly impact federal awards, including requiring political appointee review of grant decisions, restrictions on who applicants may work with, expanded rights the federal government has in modifying or terminating awards, and much more. Because these changes have significant implications for federally funded research, the University and UW Medicine are compiling an institutional response to the federal government. 

Please use the University’s “Uniform Guidance – Proposed Changes” form (UW NetID required) to provide your comments to University leadership to support the University’s official response to OMB. Your feedback and examples of impacts will inform our official UW response, and comments are still being accepted.

As a member of the public, you may also comment directly to OMB; however, OMB will consider only one comment per institution. Therefore, if you choose to submit comments to OMB in an individual capacity, you should state your experience generically (e.g. a faculty member in at a large public university) but do not mention your affiliation with the University of Washington.

Additional analysis from APLU can be found here: Summary of Uniform Guidance Issues.

More Details on Administration Budget Request

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We will continue to provide updates over the next several days and weeks but here are a few more details about the Administration budget request.

NIH

The $41 billion requested at the program level for the agency requests a $5 billion cut below the current year’s program level.  The budget summary argues that NIH “broke the trust of the American people with wasteful spending, misleading information, risky research, and the promotion of dangerous ideologies that undermine public health.”  To partly address that, the Administration is seeking to eliminate three centers or institutes:

  • National Institute on Minority Health and Health Disparities, which, according to the budget documents, is “replete with DEI expenditures”; 
  • Fogarty International Center; and,
  • National Center for Complementary and Integrative Health

ARPA-H

The agency would see its budget decrease from $1.5 billion to $945 million in FY2027.

ED

Additional programs would see lower funding levels or eliminated altogether under the budget proposal, including:

  • TRIO– $0 (currently at $1.19 billion)
  • GEAR-UP– $0 (currently at $388 million)
  • GAANN– $0 (currently at $19.5 million)
  • Federal Work Study– $123 million (currently at $1.24 billion)
  • Institute of Education Sciences (IES)– $261.3 million (currently at $790 million)

NSF

The budget request seeks to cut NSF by nearly 55%, reducing the current budget of $8.8 billion to $4 billion. Within this, there would be major cuts across the board, including: 

  • Major Research Equipment and Facilities Construction: $173 million (currently $251 million), a 31% decrease 
  • NSF Total General Science and Basic Research: $3.3 billion (currently $7.1 billion) a 53% decrease
  • STEM education programs: $151 million (currently $1.1 billion), an 86% decrease
  • Within “Research and Related Activities,” funding for the Social, Behavioral, and Economic Sciences Directorate is eliminated 
  • The Computer and Information Science and Engineering Directorate is cut by $658 million, and the Technology, Innovations, and Partnerships (TIP) Directorate is cut by $548 million
  • Consistent with a focus on “maritime dominance,” the request also includes $900.0 million in new mandatory authority to be used for construction of an Antarctic Icebreaking Vessel

Halfway through the fiscal year, NIH lags on grantmaking schedule

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As the halfway point of the federal fiscal year passes, the NIH has only obligated around 15 percent of the estimated $38 billion it has to distribute in grants and contracts, according to analysis by the Association of American Medical Colleges. The 43-day-long government shutdown in October and November is partially responsible for these delays, as well as layoffs and departures of thousands of NIH staff members since the beginning of President Trump’s second term. Despite Congress providing $47.2 billion in total funding to the NIH in FY26, the White House Office of Management and Budget (OMB) had reportedly placed a hold on releasing funds, raising concerns that the agency was not authorizing the appropriated dollars. At a March 17 House oversight hearing on the NIH, Director Jay Bhattacharya assured the subcommittee that the agency will spend every dollar it has received from Congress.

The first half of FY25 also saw a slow start to NIH awards going out the door. This trend quickly sped up by the summer, but in an effort to spend its full budget, the NIH made the unusual shift to fund more large lump-sum payments for many years of research rather than paying for research one year at a time, resulting in fewer grantees.

Jim O’Neill nominated as NSF director

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President Trump has nominated Jim O’Neill to serve as Director of the National Science Foundation. His name was among a list of nominations sent to the Senate yesterday morning. O’Neill was removed from his position as deputy secretary of HHS last month as part of a broader restructuring, which also saw Jay Bhattacharya named acting CDC director. The NSF has been without a permanent leader since last April, when director Sethuraman Panchanathan resigned as the Trump administration cut hundreds of research grants and proposed massive budget cuts.

O’Neill served as a senior HHS official during the George W. Bush administration, before moving to the private sector, where he worked closer with Peter Thiel. He was the managing director at Thiel’s Mithril Capital Management and also served as CEO of the Thiel Foundation, before joining the second Trump administration as deputy HHS secretary. If confirmed by the Senate, O’Neill would be the first non-scientist to lead the NSF.