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Health and medicine

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint precise areas of the body can reduce the medicine dosage and avoid potentially harmful “off target” effects. Researchers at the UW took a significant step toward that goal by designing proteins with autonomous decision-making capabilities. By adding smart tail structures to therapeutic proteins, the team demonstrated that the proteins could be “programmed” to act based on the presence of specific environmental cues.

Two University of Washington researchers are developing treatments that aim to simultaneously treat cancer and improve patients’ quality of life. For World Cancer Day, UW News asked them to discuss their novel materials and how these materials can treat both the cancer and the patient.

Workers from small, rural communities often move into the outer edges of cities, which offer greater economic opportunities but often have low-quality housing that is likely to suffer greater damage during an earthquake. The risk grows even more when migrants come from low-income or tribal villages.

Young adults with psychosis tend to use cannabis at extremely high rates, and their symptoms can be exacerbated by long-term marijuana use. A team of University of Washington researchers is focused on this particular group. 

Fifteen faculty members at the University of Washington have been elected to the Washington State Academy of Sciences for 2024. They are among 36 scientists and educators from across the state announced Aug. 1 as new members. Selection recognizes the new members’ “outstanding record of scientific and technical achievement, and their willingness to work on behalf of the academy to bring the best available science to bear on issues within the state of Washington.”

As often as four days a week, Boeing EA-18G Growler electronic attack aircraft based at Naval Air Station Whidbey Island fly loops overhead as pilots practice touch-and-go landings. The noise is immense. New research from the University of Washington shows that the noise isn’t just disruptive — it presents a substantial risk to public health.

Working with teens, UW researchers have designed RESeT: a snowy virtual world with six activities intended to improve mood. In a 3-week study of 44 Seattle-area teens, researchers found that most used the technology about twice a week without being prompted and reported lower stress levels after using the environment.

With several university athletic programs around the country — including the University of Washington — announcing moves to new conferences that will likely increase travel for student-athletes, a group of sleep and circadian scientists and physicians have published a white paper describing the significance of repeated, chronic jet lag on student-athlete health and performance — both in academics and in sports, and suggesting strategies to reduce the consequences of travel across time zones.

Currently, more than half of all cervical cancers diagnosed in the United States are in people who are overdue for screening or have never been screened. In a new study, researchers report that mailing HPV test kits significantly increased cervical cancer screening rates.

Two years ago, as life regained its rhythm and public transit once again filled with people, train and bus operators spotted a troubling trend. Some operators reported instances of people smoking drugs on their vehicles, and worried that the haze it created could linger, potentially affecting workers’ physical and mental health.  Spurred by operators’ concerns, five transit agencies in Washington and Oregon approached researchers at the University of Washington with a yes-or-no question: Were transit operators being exposed to drug…

On July 13, the Food and Drug Administration approved for the first time an over-the-counter birth control pill, expected to hit shelves in early 2024. The approval of the oral contraceptive Opill could drastically expand access to birth control, which for decades has been available only through a prescription. It’s a rare victory for reproductive rights — and the culmination of a 25-year effort to land birth control on drugstore shelves.   A central player in that push was Donald Downing,…

Two University of Washington faculty members have been elected to the National Academy of Sciences for 2023: Philip Greenberg, professor of medicine and of immunology at the UW, as well as the Rona Jaffe Foundation Endowed Chair at the Fred Hutchinson Cancer Center and head of the Program in Immunology in its Clinical Research Division; and Gunther Uhlmann, the Robert R. and Elaine F. Phelps Endowed Professor in Mathematics at the UW.

Researchers at the University of Washington have detected “toxic” small aggregates of a particular protein in the blood of individuals with Alzheimer’s disease, as well as in individuals who showed no signs of cognitive impairment at the time the blood sample was taken, but who developed it at a later date. This blood test picks up oligomers — or small, misfolded aggregates — of the amyloid beta protein, which scientists believe triggers the development of Alzheimer’s.

University of Washington Professor Joan Sanders and her team are creating a new type of prosthetic leg: one that automatically adjusts its fit throughout the day. Their latest prototype detects in real time how well the prosthesis socket and amputation site are fitting and responds by automatically changing the size of the socket, without the need for adjustments to padding or user action.

  As King County seeks to reach its goal of “zero youth detention” — ultimately eliminating the practice of juvenile detention in the county —University of Washington researchers are working to help address major systemic challenges in how young people engage with health care. With a strategic plan to close the juvenile detention center by 2025, King County needs an increasingly robust system to ensure youth are getting consistent and accessible services, including health care. This is especially true upon…