Researchers at the University of Washington have detected “toxic” small aggregates of a particular protein in the blood of individuals with Alzheimer’s disease, as well as in individuals who showed no signs of cognitive impairment at the time the blood sample was taken, but who developed it at a later date. This blood test picks up oligomers — or small, misfolded aggregates — of the amyloid beta protein, which scientists believe triggers the development of Alzheimer’s.
University of Washington researchers report that yeast cells can actively regulate a process called phase separation in one of their membranes. During phase separation, the membrane remains intact but partitions into multiple, distinct zones or domains that segregate lipids and proteins. The new findings show for the first time that, in response to environmental conditions, yeast cells precisely regulate the temperature at which their membrane undergoes phase separation.
Scientists and physicians have long known that immune cells migrate to the site of an infection, which individuals experience as inflammation — swelling, redness and pain. Now, researchers at the University of Washington and Northwestern University have uncovered evidence that this gathering is not just a consequence of immune activation. Immune cells count their neighbors before deciding whether or not the immune system should kick into high gear.
A team of chemical engineers has developed a new way to produce medicines and chemicals and preserve them using portable “biofactories” embedded in water-based gels known as hydrogels. The approach could help people in remote villages or on military missions, where the absence of pharmacies, doctor’s offices or even basic refrigeration makes it hard to access critical medicines and other small-molecule compounds. The team — led by Hal Alper, a professor of chemical engineering at the University of Texas, and…
Life as we know it requires phosphorus, which is scarce. So, how did a lifeless environment on the early Earth supply this key ingredient? A new UW study, published Dec. 30 in the Proceedings of the National Academy of Sciences, finds an answer to this problem in certain types of carbonate-rich lakes.
Ashleigh Theberge, a University of Washington assistant professor of chemistry, has been named a 2019 Packard Fellow for her research on cell signaling. Every year since 1988, the David and Lucile Packard Foundation has awarded Packard Fellowships in Science and Engineering to early-career scientists to pursue the types of innovative projects that often fall outside the purview of traditional sources of funding, such as research grants from government agencies. As one of 22 fellows for 2019, Theberge will receive $875,000…
Scientists have discovered that the building blocks of proteins can stabilize cell membranes. This finding may explain how the first cells emerged from the primordial soup billions of years ago: The protein building blocks could have stabilized cell membranes against salt and ions that were present in ancient oceans. In addition, membranes may have been a site for these precursor molecules to co-localize, a potential mechanism to explain what brought together the ingredients for life.
In a paper published May 29 in Nature, scientists report that the growth of chronic lymphocytic leukemia is apt to follow one of three trajectories: relentlessly upward, steadily level or something in between. The particular course the disease takes is tightly linked to the genetic makeup of the cancer cells, particularly the number of growth-spurring “driver” mutations they contain.
A team led by researchers at the University of Washington has developed synthetic peptides that target and inhibit the small, toxic protein aggregates that are thought to trigger Alzheimer’s disease.
Scientists at the University of Washington show for the first time that the complex distribution of molecules within a membrane of a living yeast cell arises through demixing.
Scientists at the University of Washington have discovered a simple way to raise the accuracy of diagnostic tests for medicine and common assays for laboratory research. By adding polydopamine — a material that was first isolated from shellfish — to these tests at a key step, the team could increase the sensitivity of these common bioassays by as many as 100 to 1,000 times.
Scientists at the University of Washington have discovered that a common type of cell in the vertebrate immune system plays a unique role in communication between other cells. It turns out that these cells, called macrophages, can transmit messages between non-immune cells.
A team of researchers from the University of Washington and the University of Trento in Italy unveiled an engineered protein that they designed to repress a specific cancer-promoting message within cells.
Scientists from the University of Washington recently reported a relatively simple method swell the tiny, complex structures within cells, bringing them within range of a common microscope’s resolving range.
A team of University of Washington researchers has identified a mechanism that some plant cells use to receive complex and contradictory messages from their neighbors.
Health Sciences Digest: Wearable Artificial Kidney safety testing to begin, low-wage workers value employer wellness initiatives, cells simply avoid chromosome errors
Filtered from a vast sodium sea, more than 1 million calcium ions per second gush through our cells’ pores to generate charges
Henrietta Lacks was the subject of bestselling book on the HeLa immortal cell line, the most used of its kind in labs around the world. The UW scientists are the first to publish under new policy, established through agreement with Lacks’ family.