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SCHOOL OF MEDICINE
PHYSIOLOGY & BIOPHYSICS

Detailed course offerings (Time Schedule) are available for

To see the detailed Instructor Class Description, click on the underlined instructor name following the course description.

P BIO 498 Undergraduate Thesis (*, max. 35)
Offered: AWSpS.

P BIO 499 Undergraduate Research (*, max. 35)
Offered: AWSpS.

P BIO 504 Biophysics of Nerve, Muscle, and Synapse (3) Sullivan
Introduces biophysical properties of nerve and muscle cells. Topics include intrinsic electrical properties of neurons, ion channels, receptor signaling, calcium signaling, contraction of muscles, and synaptic function. Offered: jointly with NEUBEH 504; A.

P BIO 505 Human Physiology (4-) Wordeman
Intensive coverage of physiology across the life span through lectures, conference. Includes excitable tissue, neurophysiology, skeletal muscle; spinal reflex; autonomic nervous system; temperature regulation, neuroendocrinology, and reproductive physiology. Required for dental, graduate nursing, and bioengineering students. Also offered for graduate students. Offered: A.
Instructor Course Description: Marc D Binder

P BIO 506 Human Physiology (-4) Berger
Intensive coverage of physiology across the life span through lectures, conference. Includes cardiovascular, respiratory physiology, renal, body fluids, gastrointestinal, and acid base balance. Required for dental, graduate nursing, and bioengineering students. Also offered for graduate students. Prerequisite: P BIO 505, or equivalent with permission of instructor. Offered: W.
Instructor Course Description: Luis F Santana

P BIO 507 Cardiovascular and Respiratory Physiology (3)
Cardiovascular physiology: the heart, microcirculation, hemodynamics, regional circulation, and reflex integration. Respiratory physiology: the lung, pulmonary circulation, alveolar ventilation, gas exchange, control of breathing, acid-base regulation, exercise. Offered: W.

P BIO 508 Introduction to Laboratory Research in Physiology (1-5, max. 15)
Students participate in the performance of ongoing projects in designated research laboratories. Emphasis is on experimental design, methodology, and techniques. For first- and second-year graduate students in physiology and biophysics to provide a basis for future independent research. Offered: AWSpS.

P BIO 509 Neuroendocrinology (3) Steiner
Emphasizes the cellular and molecular aspects of several topics in neuroendocrinology, including neuropeptide genes, reproduction, steroid hormone regulation of gene expression, mechanisms of hormone action, endocrine rhythms, and neural oscillations. Prerequisite: either BIOL 201, BIOL 202, and BIOL 203, or BIOL 180, BIOL 200, and BIOL 220; BIOC 440, BIOC 441, BIOC 442 or permission of instructor. Offered: jointly with NEUBEH 541; W, odd years.
Instructor Course Description: Robert A Steiner

P BIO 510 Physiology Survey (2)
Reading and discussion of the research literature in cellular, molecular, and systems physiology. Students write a critical evaluation of each paper in the manner of a peer review. All three quarters are required for second-year P BIO students. Prerequisite: completion of one year of P BIO graduate study. Offered: A.

P BIO 511 Physiology Survey (2)
Reading and discussion of the research literature in cellular, molecular, and systems physiology. Students write a critical evaluation of each paper in the manner of a peer review. All three quarters are required for second-year P BIO students. Prerequisite: completion of one year of P BIO graduate study. Offered: W.

P BIO 512 Physiology Survey (2)
Reading and discussion of the research literature in cellular, molecular, and systems physiology. Students write a critical evaluation of each paper in the manner of a peer review. All three quarters are required for second-year P BIO students. Prerequisite: completion of one year of P BIO graduate study. Offered: Sp.

P BIO 513 Practicum in Teaching Physiology and Biophysics (4)
Students undertake instructional material development, presentation of materials, and develop problem-solving techniques. Credit/no-credit only. Offered: AW.

P BIO 516 Physiological Proseminar (7) Hlastala
Guided survey of the experimental literature in cardiovascular and respiratory physiology. Course conducted as seminar with oral analysis of assigned papers and topics. Prerequisite: permission of instructor. Offered: A.

P BIO 518 Research Topics in Cardiovascular Physiology (1) Feigl
Graduate students and faculty members present and discuss current literature and research. Prerequisite: permission of instructor.

P BIO 519 Membrane and Muscle Biophysics Seminar (1) Hille
Lectures on current research topics in cell membrane function and muscle contraction. Prerequisite: permission of instructor. Credit/no-credit only. Offered: Sp.
Instructor Course Description: Bertil Hille

P BIO 520 Physiology Seminar (*)
Selected topics in physiology. Prerequisite: permission of instructor.

P BIO 521 Biophysics Seminar (*)
Selected topics in biophysics. Prerequisite: permission of instructor.

P BIO 522 Selected Topics in Respiratory Physiology (1-3, max. 3) Hildebrandt
Advanced seminar on selected topics, including pulmonary mechanics, gas exchange, lung fluid balance, regulation of breathing, pulmonary circulation, respiration in the neonate, liquid breathing, airway dynamics, lung structure and development, cardiopulmonary interactions, exercise physiology. Prerequisite: permission of instructor. Offered: AWSpS.

P BIO 523 Heat Transfer and Temperature Regulation (2-5, max. 5) Brengelmann
Thermal exchange between the body surface and the environment. Heat production and distribution within the body. Properties of cutaneous and deep temperature receptors. Neural integration and homeothermy. Prerequisite: permission of instructor. Credit/no-credit only.

P BIO 525 Readings in Advanced Physiology and Biophysics (*)
Guided study of the experimental literature of physiology and biophysics. Essays are written and discussed with the staff. Emphasis is placed on critical analysis, accuracy of expression, bibliographical technique, and other factors of good scholarship. Prerequisite: permission of instructor. Offered: A.

P BIO 526 Readings in Advanced Physiology and Biophysics (*)
Guided study of the experimental literature of physiology and biophysics. Essays are written and discussed with the staff. Emphasis is placed on critical analysis, accuracy of expression, bibliographical technique, and other factors of good scholarship. Prerequisite: permission of instructor. Offered: W.

P BIO 527 Readings in Advanced Physiology and Biophysics (*)
Guided study of the experimental literature of physiology and biophysics. Essays are written and discussed with the staff. Emphasis is placed on critical analysis, accuracy of expression, bibliographical technique, and other factors of good scholarship. Prerequisite: permission of instructor. Offered: SpS.

P BIO 532 Discussion in Cell Signaling and Molecular Physiology (3) Fairhall, Rieke
Discusses fundamental issues in cell excitability and molecular and cellular physiology. Focuses on problem solving and reading from original literature. Emphasizes student participation. Prerequisite: first-year graduate students in neurobiology or physiology and biophysics. Offered: jointly with NEUBEH 532; W.

P BIO 541 Motor Systems I: Peripheral, Spinal, and Cortical Mechanisms (3) Binder, Fetz
Discussion of research papers on the physiology of the motor unit and the spinal and cortical neurons that control motor unit activity. Prerequisite: NEUBEH 501-NEUBEH 503 or permission of instructor. Credit/no-credit only.

P BIO 542 Motor Systems II: Brainstem Mechanisms (3) Anderson, Fuchs
Critical discussion of research papers and resulting concepts regarding the roles of various brainstem systems in controlling somatic and ocular movements. Each student is responsible for leading the discussion of one topic. Prerequisite: NEUBEH 502 and NEUBEH 503 or equivalent and permission of instructor.

P BIO 545 Quantitative Methods in Neuroscience (3) Rieke, Shadlen
Discusses quantitative methods applicable to the study of the nervous system. Revolves around computer exercises/discussion of journal papers. May include linear systems theory, Fourier analysis, ordinary differential equations, stochastic processes, signal detection, and information theory. Prerequisite: NEUBEH 501, NEUBEH 502, NEUBEH 503, or permission of instructor. Offered: jointly with NEUBEH 545; W, odd years.

P BIO 547 Readings in Cell Physiology (2/3, max. 15) Hille
Reading and discussion of research literature on excitable cells. Emphasis on membrane excitability, transport, contractility, growth factors, and extracellular matrix. Topics vary. Prerequisite: CONJ 501 or equivalent. Offered: W.

P BIO 548 Molecular Mechanisms of Synaptic Plasticity (2) Barria
Discusses recent primary literature on the molecular mechanisms underlying structural and functional changes of dendritic spines and synapses in the mammalian brain as result of synaptic activity and experience. Offered: jointly with NEUBEH 548; Sp, odd years.

P BIO 550 Biophysics of Calcium Signaling (1) Hille, Santana
Introduction to cellular calcium signaling including theoretical and technical issues of calcium signal detection and biological conclusions. Prerequisite: CONJ 531. Offered: jointly with NEUBEH 550; Sp, odd years.

P BIO 552 Synaptic Integration (1) Binder, Powers
Discussion of recent papers on how neurons in the central nervous system integrate concurrent synaptic inputs. Includes: effects of driving force on synaptic currents, effects of conductances on dendritic properties, transfer of currents from dendrites to soma, and transformation of currents into spike train outputs. Offered: jointly with NEUBEH 552.

P BIO 553 Learning and Memory: Synapses and Systems (2) Jagadeesh, Sullivan
Five-week mini-course evaluates the current state of knowledge on the mechanisms that allow people to learn and remember. After introductory overviews of the cellular and molecular mechanisms underlying long-term synaptic plasticity and the multiple systems existing for learning and memory, students choose specific topics for discussion. Offered: jointly with NEUBEH 553.

P BIO 554 Motor Learning: Cellular and Network Mechanisms (1) Fetz, Perlmutter
Five-week mini-course reviews the current state of research on cellular and network mechanisms of motor learning. After an introductory overview of behavioral and physiological examples of motor learning in various species and systems, students choose specific topics for discussion, using the primary literature as a source. Offered: jointly with NEUBEH 554.

P BIO 555 Sensory Receptors (1) Detwiler, Rieke
Five-lecture mini-course examines how different kinds of sensory receptors detect and respond to different modalities of sensory stimuli. Discussion focuses on the cellular and molecular mechanisms of the underlying transduction processes and the experimental evidence that they are based on. Offered: jointly with NEUBEH 555.

P BIO 556 Axon Pathfinding Mechanisms (1) Bothwell
Examines mechanisms governing axon growth cone behavior during embryonic development and during regeneration in the injured adult. Discusses approaches employing both invertebrate and vertebrate model systems. Offered: jointly with NEUBEH 556.

P BIO 557 Ion Channel Gating (1) Zagotta
Compares and contrasts mechanisms of gating in ligand-gated and voltage-gated ion channels. Covers basics of ligand gating and voltage gating, kinetic schemes, inactivation and desensitization, gating currents and partial agonists, and ion channel structure. Offered: jointly with NEUBEH 557.

P BIO 558 Concepts and Mechanisms in Mitosis (2) Ashbury, Wordeman
Examines how the miotic spindle organizes and separates duplicated chromosomes during cell division. Overview of spindle components and key mechanistic concepts. Discusses recent or classic papers from the primary literature.

P BIO 559 Neurobiology of Disease (3) Garden, Neumaier, Weinstein, Weiss
Introduces medically important neurological and psychiatric diseases and experimental approaches to understanding the basis for diseases and their treatments. Covers stroke, epilespsy, autoimmune diseases of the CNS, neurodegenerative diseases, autism, psychosis, anxiety disorders, and mood disorders. Offered: jointly with NEUBEH 559/NEURL 559.

P BIO 561 From Biophysics to Neural Computation (2)
Introduces the mathematics and methods of neuronal modeling. Develops, compares, and relates dynamical systems approaches and empirical characterizations of neuronal function. Includes lectures, student-led journal paper discussions, biweekly computational workshops on neuronal modeling packages, and a computations project. Recommended: differential equations and linear algebra. Offered: jointly with NEUBEH 561; Sp.

P BIO 594 Neurological Study Unit (0.5)
Faculty and student discussion of neurological topics illustrated with clinical cases or demonstrations include the following: physiology, neuroanatomy, neurology, neuropathology, neurosurgery, and psychiatry. Prerequisite for medical students: HUBIO 532. Credit/no-credit only. Offered: AW.

P BIO 600 Independent Study or Research (*-)
Offered: AWSp.

P BIO 700 Master's Thesis (*-)
Offered: AWSpS.

P BIO 800 Doctoral Dissertation (*-)
Offered: AWSpS.