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PCEUT 327 The Science of Drugs (3) NW L. Xu
Introduces students to medicinal chemistry and pharmaceutical sciences. Recommended for sophomore, junior and senior students majoring in chemistry, biochemistry, bioengineering, chemical engineering, public health and other health sciences, and related fields. Prerequisite: CHEM 223 or CHEM 237; recommended: basic knowledge in general chemistry and organic chemistry. Offered: jointly with MEDCH 327; Sp.
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PCEUT 499 Undergraduate Research (1-6, max. 12)
Research problems in drug disposition, drug targeting, and drug development. Prerequisite: cumulative GPA of 2.50 and permission of instructor.
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PCEUT 501 Advanced Pharmacokinetics I (4) Yvonne S Lin, Bhagwat Prasad, Jashvant D Unadkat
Drug absorption, distribution, excretion, metabolism, and pharmacological effects in mammalian systems. Compartmental and physiologically-based pharmacokinetic models as well as non-compartmental approaches examined. Drug disposition studied in a physiologically realistic context taking nonlinear events into account. Aimed at development of innovative methods for data analysis and evaluation in biological systems. Prerequisite: either PCEUT 506 or permission of instructor. Offered: even years.
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PCEUT 502 Drug Disposition Science (2)
Introduction to drug metabolism and transport pharmacokinetics. Topics include basic processes of drug absorption, distribution and elimination, enzyme/transporter kinetics, associated experimental methodologies for generating kinetic parameter estimates, and principles of drug-drug interactions and other sources of inter-individual variability. Covers experimental rigor and reproducibility and research ethics. Recommended: biochemistry. Offered: A.
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PCEUT 503 Drug Transport and Delivery (5)
Provides advance knowledge of the physico-chemical and biological concepts underlying in vivo transport and delivery of drugs. Prerequisite: PCEUT 506. Instructors: Ho, Hu, Mao, Shen, Unadkat, Wang
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PCEUT 505 Concepts in Pharmaceutical Sciences I (2) R. HO
Provides the student with foundational knowledge of drug properties and interaction with physiology upon administration in vivo, and an understanding of pharmaceutical formulation which is a key disciplinary area within the pharmaceutical sciences and its application to small molecules and protein-based therapeutics. Offered: A.
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PCEUT 506 Concepts in Pharmaceutical Sciences II (4) Yvonne S Lin
Covers the fundamentals of pharmacokinetics. Includes lectures and laboratory exercises on the key concepts in pharmacokinetics, including compartmental kinetics, clearance, clinical pharmacokinetics, and an introduction to pharmacokinetic software. Prerequisite: PCEUT 505; PCEUT 532, which may be taken concurrently, or permission of instructor. Offered: W.
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PCEUT 507 Advanced Pharmacokinetics (3) Yvonne S Lin
Includes absorption kinetics, bioavailability, multi-compartment kinetics, non-linear clearance, pharmacokinetics of biologics, and animal and clinical study design. Prerequisite: either PCEUT 506 and PCEUT 532, or permission of instructor. Offered: Sp.
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PCEUT 510 Drug Interactions (3)
Covers common pharmacokinetic mechanisms underlying clinically important interactions between drugs, and patient- and drug-related factors that predispose a patient to adverse drug effects. Includes case-based discussion of approaches to identification, clinical evaluation, and clinical management of drug-drug interaction risk. Prerequisite: PHARM 558; PHARM 559; PHARM 560; PHARM 561; PHARM 563; PHARM 564, and PHARM 565. Instructors: Lin and Horn.
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PCEUT 513 Basic Concepts in Pharmacogenetics and Toxicogenomics (3) K. THUMMEL
Addresses current technologies for DNA sequencing, genotyping, RNA and epigenetic analysis and basic concepts of pharmacogenetics and toxicogenomics. Emphasis placed on applications of genomic technologies to the understanding of "gene-environment interactions" that cause variability in drug treatment responses, as well as diseases of public health importance, including cancer, chronic neurological diseases, and adverse drug reactions. Offered: jointly with ENV H 513/PHG 513; W.
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PCEUT 520 Seminar (1, max. 30) A. NATH
Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: jointly with MEDCH 520.
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PCEUT 531 Pharmaceutical Formulation: Principles and Dosage Forms (4)
Provides knowledge base for subsequent pharmacy courses and professional practice. Theory and problems involved in incorporating drugs into stable dosage forms suitable for human use and intended routes of drug administration. Fundamentals of safe and appropriate handling and use of dosage forms. Common dosage forms and basic compounding skills. Recommended: general chemistry. Offered: A.
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PCEUT 532 Clinical Pharmacokinetics (4)
Covers basic principles of pharmacokinetics and their application to the clinical setting, including: single-dose intravenous and oral kinetics, multiple dosing, nonlinear pharmacokinetics, metabolite kinetics, pharmacogenetics, and the role of disease in drug clearance and dose requirements, and kinetics of drug-drug interactions. Prerequisite: PCEUT 531. Instructors: Anderson, Isoherranen, Unadkat, Wang
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PCEUT 533 Biopharmaceutics, Drug Delivery and Therapeutic Response (3) R. HO, S. HU, K. THUMMEL
Provides basic principles of biopharmaceutics, drug delivery and therapeutic response, and their application to traditional and biotherapeutics, including oral and non-oral routes of drug administration. Discussion include fundamental principles related to assessment of bioavailability, bioequivalence, and genetic basis for drugs. Offered: Sp.
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PCEUT 534 Principles of Precision Medicine (2)
Variation in drug absorption, distribution, elimination, and response, with emphasis on pharmacokinetic-pharmacodynamic relationships. Includes pharmacogenetics, drug-drug interactions, as well as ontogenic and disease state effects and associated precision testing platforms. Uses case studies to integrate possible sources of variation and impact on individual therapeutic decisions. Prerequisite: MEDCH 501; PCEUT 531; and PCEUT 532; recommended: basic understanding of pharmacokinetics and principles of drug absorption, distribution and elimination and drug response. Offered: Sp.
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PCEUT 570 Advanced Research Topics (1, max. 15)
Combines a discussion of the practical aspects and experimental techniques used to address the questions relating to drug disposition with comprehensive theoretical treatment of pharmacokinetic principles. Prerequisite: permission of the instructor. Credit/no-credit only.
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PCEUT 583 Topics in Pharmaceutics (1, max. 30) N. KLATT, K. THUMMEL
Discussion of pertinent articles from current literature and recent laboratory results. Credit/no-credit only.
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PCEUT 584 Pharmacokinetic Discussion Group (2) Lin
Student initiated discussions of pharmaceutics concepts in relation to current literature. Preparatory to departmental cumulative examinations. Credit/no-credit only.
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PCEUT 586 Biotechnology and Biopharmaceutics (2-3) Ho, Hu, Kelly, Thummel
Current topics in pharmaceuticals and biotechnology focusing on transforming small molecules, proteins, and genes into therapeutic products. Includes new drug therapies, drug design, pharmacogenomics, molecular modeling, high throughput screen, production and stability considerations, and delivery systems of protein and gene therapeutics in relation to pharmacokinetic and therapeutic responses.
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PCEUT 587 Introduction to Biopharmaceutical Product Development (3)
Provides a framework of the drug development process and its regulation. Prerequisite: ENV H 405 or ENV H 514, ENV H 515, and ENV H 516, or PCEUT 501, PCEUT 502, and PCEUT 503; or equivalent, or instructor permission. Offered: jointly with ENV H 587; A, even years.
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PCEUT 598 Independent Research (*, max. 24)
Basic and clinical research problems in drug disposition and effect. Prerequisite: minimum grade of 2.50 GPA and permission of instructor.
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PCEUT 599 Cumulative Exams for Pharmaceutics (1-, max. 3) Y. Lin
Quarterly cumulative examinations for graduate students.
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PCEUT 600 Independent Study or Research (*-)
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PCEUT 700 Master's Thesis (*-)
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PCEUT 800 Doctoral Dissertation (*-)
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