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SCHOOL OF MEDICINE
PHYSIOLOGY & BIOPHYSICS

Detailed course offerings (Time Schedule) are available for

P BIO 498 Undergraduate Thesis (*, max. 35)
Offered: AWSpS.
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P BIO 499 Undergraduate Research (*, max. 35)
Offered: AWSpS.
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P BIO 504 Biophysics of Nerve, Muscle, and Synapse (3) Sullivan
Introduces biophysical properties of nerve and muscle cells. Topics include intrinsic electrical properties of neurons, ion channels, receptor signaling, calcium signaling, contraction of muscles, and synaptic function. Offered: jointly with NEUBEH 504; A.
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P BIO 505 Human Physiology (4-) Binder
Provides an introduction to the study of human physiology. Covers the physiology of excitable cells, muscle physiology, renal physiology, gastrointestinal physiology, and the physiology of the central nervous system. Offered: A.
View course details in MyPlan: P BIO 505

P BIO 506 Human Physiology (-4) Wordeman
Provides an introduction to the study of human physiology. Covers cardiovascular physiology, respiratory physiology, acid base balance, neuroendocrinology, and reproductive physiology. Prerequisite: P BIO 505, or equivalent with permission of instructor. Offered: W.
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P BIO 508 Introduction to Laboratory Research in Physiology (1-5, max. 15)
Students participate in the performance of ongoing projects in designated research laboratories. Emphasis is on experimental design, methodology, and techniques. For first- and second-year graduate students in physiology and biophysics to provide a basis for future independent research. Offered: AWSpS.
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P BIO 509 Neuroendocrinology (3) Steiner
Emphasizes the cellular and molecular aspects of several topics in neuroendocrinology, including neuropeptide genes, reproduction, steroid hormone regulation of gene expression, mechanisms of hormone action, endocrine rhythms, and neural oscillations. Prerequisite: either BIOL 201, BIOL 202, and BIOL 203, or BIOL 180, BIOL 200, and BIOL 220; BIOC 440, BIOC 441, BIOC 442 or permission of instructor. Offered: jointly with NEUBEH 541; W, even years.
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P BIO 513 Practicum in Teaching Physiology and Biophysics (4)
Students undertake instructional material development, presentation of materials, and develop problem-solving techniques. Credit/no-credit only. Offered: AW.
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P BIO 519 Membrane and Muscle Biophysics Seminar (1) Hille
Lectures on current research topics in cell membrane function and muscle contraction. Prerequisite: permission of instructor. Credit/no-credit only. Offered: Sp.
View course details in MyPlan: P BIO 519

P BIO 520 Physiology Seminar (*)
Selected topics in physiology. Prerequisite: permission of instructor.
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P BIO 521 Biophysics Seminar (*)
Selected topics in biophysics. Prerequisite: permission of instructor.
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P BIO 522 Selected Topics in Respiratory Physiology (1-3, max. 3) Hildebrandt
Advanced seminar on selected topics, including pulmonary mechanics, gas exchange, lung fluid balance, regulation of breathing, pulmonary circulation, respiration in the neonate, liquid breathing, airway dynamics, lung structure and development, cardiopulmonary interactions, exercise physiology. Prerequisite: permission of instructor. Offered: AWSpS.
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P BIO 523 Heat Transfer and Temperature Regulation (2-5, max. 5) Brengelmann
Thermal exchange between the body surface and the environment. Heat production and distribution within the body. Properties of cutaneous and deep temperature receptors. Neural integration and homeothermy. Prerequisite: permission of instructor. Credit/no-credit only.
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P BIO 525 Readings in Advanced Physiology and Biophysics (*)
Guided study of the experimental literature of physiology and biophysics. Essays are written and discussed with the staff. Emphasis is placed on critical analysis, accuracy of expression, bibliographical technique, and other factors of good scholarship. Prerequisite: permission of instructor. Offered: A.
View course details in MyPlan: P BIO 525

P BIO 526 Readings in Advanced Physiology and Biophysics (*)
Guided study of the experimental literature of physiology and biophysics. Essays are written and discussed with the staff. Emphasis is placed on critical analysis, accuracy of expression, bibliographical technique, and other factors of good scholarship. Prerequisite: permission of instructor. Offered: W.
View course details in MyPlan: P BIO 526

P BIO 527 Readings in Advanced Physiology and Biophysics (*)
Guided study of the experimental literature of physiology and biophysics. Essays are written and discussed with the staff. Emphasis is placed on critical analysis, accuracy of expression, bibliographical technique, and other factors of good scholarship. Prerequisite: permission of instructor. Offered: SpS.
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P BIO 545 Quantitative Methods in Neuroscience (3) Rieke
Discusses quantitative methods applicable to the study of the nervous system. Revolves around computer exercises/discussion of journal papers. May include linear systems theory, Fourier analysis, ordinary differential equations, stochastic processes, signal detection, and information theory. Prerequisite: NEUBEH 501, NEUBEH 502, NEUBEH 503, or permission of instructor. Offered: jointly with NEUBEH 545; W, odd years.
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P BIO 548 Molecular Mechanisms of Synaptic Plasticity (2) Barria
Discusses recent primary literature on the molecular mechanisms underlying structural and functional changes of dendritic spines and synapses in the mammalian brain as result of synaptic activity and experience. Offered: jointly with NEUBEH 548; Sp, even years.
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P BIO 550 Biophysics of Calcium Signaling (1) Hille, Santana
Introduction to cellular calcium signaling including theoretical and technical issues of calcium signal detection and biological conclusions. Prerequisite: P BIO 504/NEUBEH 504. Offered: jointly with NEUBEH 550; Sp, odd years.
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P BIO 554 Motor Learning: Cellular and Network Mechanisms (1) Fetz, Perlmutter
Five-week mini-course reviews the current state of research on cellular and network mechanisms of motor learning. After an introductory overview of behavioral and physiological examples of motor learning in various species and systems, students choose specific topics for discussion, using the primary literature as a source. Offered: jointly with NEUBEH 554.
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P BIO 555 Sensory Receptors (1) Detwiler, Rieke
Five-lecture mini-course examines how different kinds of sensory receptors detect and respond to different modalities of sensory stimuli. Discussion focuses on the cellular and molecular mechanisms of the underlying transduction processes and the experimental evidence that they are based on. Offered: jointly with NEUBEH 555.
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P BIO 556 Axon Pathfinding Mechanisms (1) Bothwell
Examines mechanisms governing axon growth cone behavior during embryonic development and during regeneration in the injured adult. Discusses approaches employing both invertebrate and vertebrate model systems. Offered: jointly with NEUBEH 556.
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P BIO 557 Ion Channel Gating (1) Zagotta
Compares and contrasts mechanisms of gating in ligand-gated and voltage-gated ion channels. Covers basics of ligand gating and voltage gating, kinetic schemes, inactivation and desensitization, gating currents and partial agonists, and ion channel structure. Offered: jointly with NEUBEH 557.
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P BIO 558 Concepts and Mechanisms in Mitosis (2) Asbury, Wordeman
Examines how the miotic spindle organizes and separates duplicated chromosomes during cell division. Overview of spindle components and key mechanistic concepts. Discusses recent or classic papers from the primary literature.
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P BIO 559 Neurobiology of Disease (3) Garden, Neumaier, Weinstein
Introduces medically important neurological and psychiatric diseases and experimental approaches to understanding the basis for diseases and their treatments. Covers stroke, epilespsy, autoimmune diseases of the CNS, neurodegenerative diseases, autism, psychosis, anxiety disorders, and mood disorders. Offered: jointly with NEUBEH 559/NEURL 559.
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P BIO 561 From Biophysics to Neural Computation (2)
Introduces the mathematics and methods of neuronal modeling. Develops, compares, and relates dynamical systems approaches and empirical characterizations of neuronal function. Includes lectures, student-led journal paper discussions, biweekly computational workshops on neuronal modeling packages, and a computations project. Recommended: differential equations and linear algebra. Offered: jointly with NEUBEH 561; Sp.
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P BIO 600 Independent Study or Research (*-)
Offered: AWSp.
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P BIO 700 Master's Thesis (*-)
Offered: AWSpS.
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P BIO 800 Doctoral Dissertation (*-)
Offered: AWSpS.
View course details in MyPlan: P BIO 800