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PCEUT 499 Undergraduate Research (1-6, max. 12)
Research problems in drug disposition, drug targeting, and drug development. Prerequisite: cumulative GPA of 2.50 and permission of instructor.

PCEUT 501 Advanced Pharmacokinetics I (5) Lin, Unadkat
Drug absorption, distribution, excretion, metabolism, and effects in mammalian systems. Compartmental and physiologically-based pharmacokinetic models as well as non-compartmental approaches examined. Drug disposition studied in a physiologically realistic context taking nonlinear events into account. Aimed at development of innovative methods for data analysis (including population pharmacokinetic and pharmacodynamic models) and evaluation in biological systems. Prerequisite: PCEUT 506 or permission of instructor.
Instructor Course Description: Jashvant D Unadkat

PCEUT 502 Pharmacokinetics of Drug Metabolism (4) Kunze, Thummel
Advanced study of drug metabolism pharmacokinetics. Topics emphasize linear and nonlinear metabolic clearance kinetics, metabolite kinetics, in vitro-in vivo predictions, and drug-drug interaction kinetics. Prerequisite: PCEUT 506 or permission of instructor. Offered: even years.

PCEUT 503 Drug Transport and Delivery (5) Ho, Hu, Mao, Shen, Unadkat, Wang
Provides advance knowledge of the physico-chemical and biological concepts underlying in vivo transport and delivery of drugs. Prerequisite: PCEUT 506.

PCEUT 506 Pharmacokinetic Principles (6) Lin
Covers the fundamentals of pharmacokinetics. Includes lectures and laboratory exercises on the key concepts in pharmacokinetics, including compartmental kinetics, clearance, protein binding, bioavailability, pharmacodynamics, clinical pharmacokinentics, and Michaelis-Menten kinetics.

PCEUT 510 Drug Interactions (3) Collins, Horn, Lin, Shen
Covers common pharmacokinetic mechanisms underlying clinically important interactions between drugs, and patient- and drug-related factors that predispose a patient to adverse drug effects. Includes case-based discussion of approaches to identification, clinical evaluation, and clinical management of drug-drug interaction risk. Prerequisite: PHARM 558; PHARM 559; PHARM 560; PHARM 561; PHARM 563; PHARM 564, and PHARM 565.

PCEUT 513 Basic Concepts in Pharmacogenetics and Toxicogenomics (3) Eaton, Thummel
Addresses current DNA sequencing and genotyping approaches, and basic concepts of pharmacogenetics and toxicogenomics. Emphasis placed on applications of genomic technologies to the understanding of "gene-environment interactions" that cause diseases of public health importance, including cancer, chronic neurological diseases, and adverse drug reactions. Offered: jointly with ENV H 513/PHG 513; W.

PCEUT 520 Seminar (1, max. 30) A. NATH
Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: jointly with MEDCH 520.

PCEUT 531 P-Pharmaceutical Formulation: Principles and Dosage Forms (4) Lee, Mao, Shen
Physiochemical principles involved in formulating stable dosage forms suitable for human administration. Hands-on laboratory experience with formulating extemporaneous preparations routinely encountered in community and hospital pharmacies. Routes of drug administration.

PCEUT 532 P-Clinical Pharmacokinetics (4) Anderson, Isoherranen, Unadkat, Wang
Covers basic principles of pharmacokinetics and their application to the clinical setting, including: single-dose intravenous and oral kinetics, multiple dosing, nonlinear pharmacokinetics, metabolite kinetics, pharmacogenetics, and the role of disease in drug clearance and dose requirements, and kinetics of drug-drug interactions. Prerequisite: PCEUT 531.

PCEUT 533 P-Biopharmaceutics, Drug Delivery and Therapeutic Resonse (4) Ho
Covers basic principles of biopharmaceutics drug delivery, and therapeutic response and their application to traditional and biotherapeutics, including oral and non-oral route of drug administration. Includes fundamental principles related to assessment of bioavailability and bioequivalence, drug-drug, and food-drug interactions and genetic basis for oral or parenteral drugs. Prerequisite: PCEUT 532. Offered: Sp.
Instructor Course Description: Rodney J.Y. Ho

PCEUT 570 Advanced Research Topics (1, max. 15)
Combines a discussion of the practical aspects and experimental techniques used to address the questions relating to drug disposition with comprehensive theoretical treatment of pharmacokinetic principles. Prerequisite: permission of the instructor. Credit/no-credit only.

PCEUT 583 Topics in Pharmaceutics (1, max. 30) Isoherranen
Discussion of pertinent articles from current literature and recent laboratory results. Credit/no-credit only.

PCEUT 584 Pharmacokinetic Discussion Group (2) Lin
Student initiated discussions of pharmaceutics concepts in relation to current literature. Preparatory to departmental cumulative examinations. Credit/no-credit only.

PCEUT 586 Biotechnology and Biopharmaceutics (2-3) Ho, Hu, Kelly, Thummel
Current topics in pharmaceuticals and biotechnology focusing on transforming small molecules, proteins, and genes into therapeutic products. Includes new drug therapies, drug design, pharmacogenomics, molecular modeling, high throughput screen, production and stability considerations, and delivery systems of protein and gene therapeutics in relation to pharmacokinetic and therapeutic responses.
Instructor Course Description: Edward J Kelly Rodney J.Y. Ho

PCEUT 587 Introduction to Biopharmaceutical Product Development (3) Kelly
Provides a framework of the drug development process and its regulation. Prerequisite: ENV H 405 or ENV H 514, ENV H 515, and ENV H 516, or PCEUT 501, PCEUT 502, and PCEUT 503; or equivalent, or instructor permission. Offered: jointly with ENV H 587; A, even years.
Instructor Course Description: Edward J Kelly

PCEUT 598 Independent Research (*, max. 24)
Basic and clinical research problems in drug disposition and effect. Prerequisite: minimum grade of 2.50 GPA and permission of instructor.

PCEUT 599 Cumulative Exams for Pharmaceutics (1-, max. 3) Isoherranen
Quarterly cumulative examinations for graduate students.

PCEUT 600 Independent Study or Research (*-)
Credit/no-credit only.

PCEUT 700 Master's Thesis (*-)
Credit/no-credit only.

PCEUT 800 Doctoral Dissertation (*-)
Credit/no-credit only.