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SCHOOL OF MEDICINE
PHARMACOLOGY

Detailed course offerings (Time Schedule) are available for

PHCOL 401 General Pharmacology I (2-4, max. 4) Wang
Principles governing drug-receptor interactions, dose-response relationships, desensitization, and tolerance. Drug toxicity, allergy, mutagenesis, and carcinogensis. Pharmocogenomics and DNA/RNA therapies. General pharmacology of drugs acting on the endocrine and vascular systems. For pharmacy students and other undergraduates. Recommended: background in biology, biochemistry, and introductory physiology. Offered: A.
MyPlan Course Details: PHCOL 401 (student access only)

PHCOL 402 General Pharmacology II (3/4) Storm
General pharmacology of drugs acting on the autonomic, cardiovascular, and central nervous systems. For Pharmacy students and other undergraduates. Prerequisite: PHCOL 401. Offered: W.
MyPlan Course Details: PHCOL 402 (student access only)

PHCOL 434 General Pharmacology (2) Grubbs
Lectures concerning the action of drugs on physiological and pathological processes with special emphasis on agents of special importance in the practice of dentistry. For dental students. Offered: A.
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PHCOL 435 General Pharmacology (2) Grubbs
Lectures concerning the action of drugs on physiological and pathological processes with special emphasis on agents of special importance in the practice of dentistry. For dental students. Offered: W.
MyPlan Course Details: PHCOL 435 (student access only)

PHCOL 498 Undergraduate Thesis (*, max. 35)
Offered: A.
MyPlan Course Details: PHCOL 498 (student access only)

PHCOL 499 Undergraduate Research (*, max. 35)
Participation in departmental research projects. Offered: AWSpS.
MyPlan Course Details: PHCOL 499 (student access only)

PHCOL 507 Pharmacology Seminar (1, max. 30)
Presentation of comprehensive reports on recent medical and scientific literature in fields of current importance. Research progress reports, and reports on results of completed research. Prerequisite: permission of instructor. Offered: AWSp.
MyPlan Course Details: PHCOL 507 (student access only)

PHCOL 510 Drug Discovery and Emerging Therapeutics (2) Zheng
Consideration of the general principles and current approaches involved in modern drug discovery and development, with an emphasis on basic concepts in drug action, delivery, and metabolism. Discussion of novel drug discovery techniques and emerging non-standard therapeutics. Prerequisite: organic chemistry, biochemistry, and introductory anatomy and physiology. Offered: W.
MyPlan Course Details: PHCOL 510 (student access only)

PHCOL 511 Autonomic/Cardiovascular Pharmacology (2.5) Nathanson
Consideration of the pharmacology of the cardiovascular and autonomic nervous systems. Emphasizes the mechanisms of neurotransmitter, hormone, drug action at autonomic synapses, and the molecular basis for physiology and pathophysiology of the cardiovascular system. Lectures, group discussion, and analysis of recent research. Prerequisite: organic chemistry, biochemistry, and introductory anatomy and physiology. Offered: W.
MyPlan Course Details: PHCOL 511 (student access only)

PHCOL 512 Neuropharmacology (2) Bajjalieh
Consideration of the neurobiological basis of drug action on the central nervous system, including mechanism of action and therapeutic use in psychiatric disorders; neurodegeneration/neuroinflammation; control of neuronal excitability and pain; and drug abuse and addition. Lecture, group discussion, and analysis of recent research. Recommended: organic chemistry, biochemistry, and introductory anatomy and physiology. Offered: Sp.
MyPlan Course Details: PHCOL 512 (student access only)

PHCOL 513 Endocrine Pharmacology and Chemotherapuetics (2) McKnight
Consideration of the pharmacology of endocrine systems including the hypothalamic/pituitary regulatory peptides, glycoprotein hormones/growth factors, peptide and steroid hormones. Basic principles of chemotherapy of endocrine and other cancers, as well as viral and microbial diseases. Lecture, group discussion, and analysis of recent research. Prerequisite: organic chemistry, biochemistry, and introductory anatomy and physiology. Offered: Sp.
MyPlan Course Details: PHCOL 513 (student access only)

PHCOL 514 Current Topics in Pharmacology (1, max. 30) Gardner
Current research related to the mechanisms of drug action presented in a seminar format. Presentations include relevant background material as well as detailed experimental results taken from current research articles. Prerequisite: permission of instructor. Offered: AWSp.
MyPlan Course Details: PHCOL 514 (student access only)

PHCOL 515 General Pharmacology Laboratory (*, max. 9)
Laboratory course for professional and graduate students who wish to do independent laboratory research under the direction of a specific faculty member. Prerequisite: permission of instructor. Offered: AWSp.
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PHCOL 519 Introduction to Laboratory Research in Pharmacology (4) Storm
On a rotation basis students carry out individual research projects in the laboratories of different faculty members. At the end of each quarter students make formal presentations of their work. For first-year graduate students in pharmacology. Offered: AWSpS.
MyPlan Course Details: PHCOL 519 (student access only)

PHCOL 527 DRUG METABOLISM (4) A. RETTIE, K. THUMMEL
Considerations of the biochemical mechanisms for the biotransformation of drugs and foreign compounds. Includes reaction mechanisms, ultrastructural considerations,induction mechanisms, methodology, kinetics of inhibition and activation, steroid and amine metabolism. Offered: jointly with MEDCH 527; W, odd years.
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PHCOL 529 Ion Channel Pharmacology (2) Catterall, Tempel
Current topics in ion channel structure, function, genetics, and pharmacology, including consideration of role in electrical signaling in cell membranes and information transfer and processing in nervous system, inherited diseases of ion channels, and sites and mechanisms of action of drugs and toxins. Prerequisite: CONJ 532 and CONJ 536 or permission of instructor. Offered: A, odd years.
MyPlan Course Details: PHCOL 529 (student access only)

PHCOL 530 Neuronal Signaling Pathways (2) Beavo, Hague, Storm, Xia
Advanced consideration of the molecular events between drug or hormone binding to receptors and the resulting responses. Emphasizes roles played by signal transduction pathways in regulation of synaptic plasticity, memory formation, neuronal apoptosis, and developmental neurobiology. Prerequisite: UCONJ 532 or permission of instructor. Offered: W, even years.
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PHCOL 531 Genetic Analysis of Signaling Systems (3) McKnight, Moon
Current topics involving signal transduction are discussed with an emphasis on genetic analysis of multicellular systems and creative experimental design. Prerequisite: 9 credits of graduate-level courses in molecular and cellular biology, biochemistry, or genetics, or permission of instructor. Offered: Sp, odd years.
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PHCOL 534 Molecular Basis of Addictive Drug Action (2) Chavkin, Phillips, Stella
Advanced consideration and discussion of current literature addressing the basis of opiate, psychostimulant, and cannabinoid effects on signal transduction events, electrical activity of neurons, and drip-motivated behaviors in animal models of human drug abuse. Prerequisite: PHCOL 512 or permission of instructor. Offered: A, even years.
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PHCOL 535 Transcriptional Control in Human Disease (3) Bomsztyk, Wang
Advanced consideration and discussion of the mechanisms regulating transcription/gene expression and of aberrant transcription factors which disrupt this process found in cancer and other human diseases. Prerequisite: PHCOL 512 or permission of instructor. Offered: Sp, even years.
MyPlan Course Details: PHCOL 535 (student access only)

PHCOL 550 An Overview of Faculty Research (1) Wang
Reviews research topics currently being studied in pharmacology. Student reads articles published on each topic. Prerequisite: first-year student standing in pharmacology. Credit/no-credit only. Offered: A.
MyPlan Course Details: PHCOL 550 (student access only)

PHCOL 560 Regulation of Cell Function by Cyclic Nucleotide Phosphodiesterases (1) Beavo
Discussion of research strategies, methodologies, and literature relating to regulation of cyclic nucleotide levels in the cell. Emphasis on practical problem solving, data analysis, and presentation of methods important to understanding published data and designing new experiments in this area of research. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 560 (student access only)

PHCOL 561 Molecular Properties of Ion Channels (1) Catterall
Discussion of research strategies, methodologies, and literature concerning the structure, function, and regulation of sodium and calcium channels and the mechanism of action of drugs on them. Emphasis on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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PHCOL 562 Molecular Basis for Motivated Behavior (1) Chavkin
Discussion of research strategies and methodologies involved in the regulation of motivated behavior by understanding signal transduction and synaptic physiology. Emphasis on practical problem solving, data analysis, and presentation methods important to modern scientific work. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 562 (student access only)

PHCOL 563 Signal Transduction Mechanisms in Neuroplasticity and Neuron Growth (1) Storm
Discussion of research strategies, methodologies, and literature relating to signal transduction mechanisms important for neuroplasticity and regulation of neuron growth in the central nervous system. Emphasis on practical problem solving, data analysis, and presentation methods important to modern scientific work. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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PHCOL 564 Cellular Regulation by Protein Kinases (1) McKnight
Analysis of research problems, techniques, and emerging concepts in the study of the function of protein kinases. Emphasis on critical evaluation of research and development of presentation skills. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 564 (student access only)

PHCOL 565 Intercellular Signaling in Development (1) Moon
Molecular genetic approaches to dissecting the roles and mechanisms of intracellular signaling during development. Emphasis on vertebrate genes related to Drosophilia segment polarity genes. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 565 (student access only)

PHCOL 566 Molecular Pharmacology of Neurotransmitter and Neurokine Receptors (1) Nathanson
Discussion of research strategies and methodologies in the areas of molecular neurobiology and signal transduction of muscarinic receptors, G-proteins, and neurokine receptors. Emphasis on practical problem solving, data analysis, and presentation methods important to modern scientific work. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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PHCOL 567 Mechanisms of Carcinogenesis (2)
Lectures/presentations of biochemical and molecular basis of carcinogenesis induced by environmental agents, including approaches to identification of carcinogens. Role of cell proliferation and cell death (apoptosis) in cancer formation and cancer treatment. Molecular mechanisms that regulate proliferation and apoptosis. Prerequisite: ENV H 516, ENV H 405, or permission of instructor. Offered: jointly with ENV H 567; A, even years.
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PHCOL 569 Molecular Genetics of Potassium Channel Function (1) Tempel
Discussion of research strategies, methodologies, and literature concerning the structure, function, and regulation of potassium channel genes and their role in behavior as studied in mutant mice. Emphasis on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 569 (student access only)

PHCOL 571 Molecular Mechanisms of Neurosecretion (1) Bajjalieh
Discussion of research strategies, methodologies, and literature relating to regulation of cyclic nucleotide levels in the cell. Emphasis on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only.
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PHCOL 572 Transcriptional Regulation of Growth Control Genes (1) Wang
Discussion of research strategies, methodologies, and literature relating to proliferative growth control, cellular differentiation, and gene expression. Emphasis on practical problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only.
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PHCOL 573 Signaling Systems Linked to Neuroinflammation (1) Stella
Discussion of research strategies, methodologies, and literature related to neuroinflammation, microglial cell activation, and the cannabinoid signaling pathway. Emphasis on solving practical problem, data analysis, and presentation. Prerequisite: permission of instructor. Offered: AWSpS.
MyPlan Course Details: PHCOL 573 (student access only)

PHCOL 575 Structural Biology of Ubiquitination (1) Zheng
Discussion of research strategies, methodologies and literature concerning the structure, function, and regulation of ubiquitin-protein ligases and the mechanism underlying ubiquitination and ubiquitin-dependent proteolysis. Emphasis on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 575 (student access only)

PHCOL 576 Pharmacological, Molecular, and Functional Characterization of G-protein Coupled Receptors (1) Hague
Discusses research strategies, methodologies, and literature relating to the pharmacological characterization, molecular biology, and functional coupling of GPCRs. Emphasizes practical problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 576 (student access only)

PHCOL 577 Regulatory Roles of Ubiquitin in the Nucleus (1) Gardner
Focuses on the design and implementation of research aimed at understanding the nuclear functions of the small protein modifier ubiquitin. Strongly emphasizes the understanding of current literature, experimental design and troubleshooting, data analysis, and presentation of experimental results. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 577 (student access only)

PHCOL 578 A-Kinase Anchoring Proteins in Cell Signaling Research (1) Scott
Focuses on the design and implantation of research A-Kinase anchoring proteins in cell signaling. Emphasizes understanding experimental design and troubleshooting, data analysis, and presentation of experimental results. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 578 (student access only)

PHCOL 579 Genetic Regulation of Emotional Behavior (1) Zweifel
Provides background in the materials and methods used in the study of the genetic basis of learning and memory and neural circuit function achieved through discussion of current literature, data acquisition and analysis, and experimental design. Offered: AWSpS.
MyPlan Course Details: PHCOL 579 (student access only)

PHCOL 580 Proteomics for Cellular Systems (1) Ong
Discusses and reviews literature for proteomics and other genome-wide approaches to study cellular systems. Trains students to integrate knowledge form existing literature with ongoing laboratory research to enhance data analysis and experimental design. Offered: AWSpS.
MyPlan Course Details: PHCOL 580 (student access only)

PHCOL 600 Independent Study or Research (*-)
Pharmacology graduate students only. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 600 (student access only)

PHCOL 700 Master's Thesis (*-)
Pharmacology graduate students only. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 700 (student access only)

PHCOL 800 Doctoral Dissertation (*-)
Pharmacology graduate students only. Credit/no-credit only. Offered: AWSpS.
MyPlan Course Details: PHCOL 800 (student access only)