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SCHOOL OF MEDICINE
PATHOLOGY

Detailed course offerings (Time Schedule) are available for

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PATH 450 Cell Biology of Aging (3) Martin, Rabinovitch, Wolf
Pathophysiology of aging at cell and tissue levels (cell replication limits, telomere shortening, accrual of oxidative damage, caloric restriction effects, loss of postreplicative cells, longevity assurance genes). Proseminar based on student participation. Undergraduate Honors students, graduate students with biology, zoology, genetics, or medical sciences backgrounds. Prerequisite: permission of instructor. Offered: W.
Instructor Course Description: Norman S Wolf

PATH 498 Undergraduate Thesis (*, max. 35)
Elective.

PATH 499 Undergraduate Research (*, max. 35)
Elective.
Instructor Course Description: George Martin

PATH 500 Molecular Basis of Disease (3) Parks
Designed for first and second-year graduate students to introduce the concepts of general pathology at the cellular and molecular levels. Offered: W.

PATH 501 Pathology Proseminars (1, max. 9)
Small group discussions and presentations by students based on critical reading of original papers, or on concurrent seminars, in many areas of experimental pathology and medicine. Topic varies by quarter. Prerequisite: permission of instructor. Offered: AWSpS.
Instructor Course Description: Morayma Reyes

PATH 502 Inflammation and Repair (2)
Lecture-seminar; a seminar course dealing with an in-depth examination of the processes involved in inflammation and repair. Prerequisite: permission of instructor. Credit/no-credit only. Offered: even years.

PATH 507 Introduction to Pathology Research (2) Bornfeldt, Swisshelm
Current developments and approaches to investigation of the molecular and cellular basis of disease. Members of the Pathology faculty present and discuss their own research projects. Prerequisite: permission of instructor. Credit/no-credit only. Offered: A.

PATH 510 Introduction to Pathology Methods (3) Bowen-Pope
Laboratory course designed to introduce graduate students to the fundamentals of image analysis, histology, histopathology, post mortem evaluation, surgical pathology, and other methods used to investigate disease etiology, progression, and manifestation in humans and in animal models. Prerequisite: permission of instructor. Credit/no-credit only. Offered: Sp.
Instructor Course Description: Daniel Bowen-Pope

PATH 511 Topics in Experimental Pathology (1-2, max. 10) Bornfeldt
Focus on areas of research relevant to experimental pathology. Prerequisite: permission of instructor. Offered: AWSpS.

PATH 512 Molecular Basis of Disease: Death and Repair (1.5)
First in a series designed to introduce students to medically important diseases and physiologic processes and experimental approaches to elucidating the cellular processes underlying these diseases. Covers basic cell/tissue processes that underlie normal homeostasis and most disease and, including apoptosis, necrosis, stem cells, inflammation, granulation tissue, tissue regeneration, repair and fibrosis.
Instructor Course Description: Ian N. Crispe

PATH 513 Mechanisms of Neurodegeneration (1.5)
Introduction to the cellular and molecular mechanisms that underlie neurodegenerative diseases, including introduction to the normal development and anatomy of the central nervous system, a review of epidemiologic, genetic, and clinical research tools used in the investigation of these diseases, and a systematic review of the major neurodegenerative diseases.
Instructor Course Description: Christopher D Keene

PATH 516 Molecular Basis of Human Genetic Disease (3)
Introduces the underlying mechanisms in human genetic disorders, ranging from the single nucleotide, through genomic instability, and chromosomal rearrangements. Includes tissue and organ specific examples of the manner in which these disorders provide insights into human biology. Offered: Sp.

PATH 517 The Biology and Pathology of Aging (3/4) Wolf
Surveys the biology and pathologies of the aging phenomena in multiple species and at multiple organismal levels from whole animals to molecules. Prerequisite: coursework in biology, biochemistry, molecular biology, and genetics. Offered: Sp.

PATH 520 Experimental Pathology Seminar (1)
Review of current research in various areas of experimental pathology by members of the department and visiting scientists. Credit/no-credit only.

PATH 521 Anatomy and Autopsy (1) Fligner
Students view an autopsy, and learn how autopsy can diagnose disease, determine cause of death, and improve patient care. Requirements include orientation session, autopsy, and a clinical-autopsy conference. Participants must be free at least one morning per week to attend an autopsy at UWMC. Prerequisite: UW medical students only. Offered: WSp.

PATH 522 Hematopathology Seminar (2) Wood
Identification of normal lymphocyte and bone marrow subpopulations, diagnosis of leukemias, lymphomas, and benign conditions that resemble them. Emphasis on histopathology, cytochemical, immunological, and molecular markers. Clinicopathologic correlation. Offered: jointly with LAB M 522; W, even years.

PATH 530 Human Cytogenetics (*, max. 4) Disteche
Sources and methods of preparation and identification of human chromosomes. Molecular structure and mapping of chromosomes. Human cytogenetic pathology: karyotype-phenotype interactions, chromosome breakage, and cancer cytogenetics. Prerequisite: permission of instructor. Offered: Sp.

PATH 540 Translational Research Topics (1) Horwitz
First and second year students in the M.D./Ph.D. program present and discuss current papers form the biomedical literature in journal club format, and describe their own research in seminar format. Credit/no-credit only. Offered: AWSp.

PATH 544 General and Systemic Pathology ([2-3]-, max. 5) Narayanan
Basic pathologic processes that underlie disease, including cell alterations, genetic and developmental pathology, environmental pathology, neoplasia, immunopathology, inflammation, infection, and systemic diseases. Correlates gross, functional, and biochemical alterations. For first-year dental students and graduate students. Requires reasonable grounding in biological and chemical sciences. Prerequisite for nondental students: permission of instructor.

PATH 551 Experimental and Molecular Pathology (2-5, max. 20)
Introduction to experimental pathology. A tutorial course designed to introduce a graduate student (medical, dental) or senior undergraduate to selected methods and problems through literature surveys and/or laboratory experience. Exploration of causes at the cellular and molecular levels in the study of disease is emphasized. Prerequisite: permission of instructor. Credit/no-credit only.

PATH 552 Contemporary Anatomic Pathology (2-5, max. 30) Schwartz
Study of recent developments in anatomic pathology. Subject includes areas of basic science and review of systemic pathology. Recent developments and interpretation of these findings are stressed. For pathology residents, fellows, and trainees. Prerequisite: permission of instructor. Credit/no-credit only.

PATH 555 Environmental Pathology (3) Monnat, Rhim
Modern morphologic, cell biological, and molecular approaches to environmental disease associated with exposure/predisposition. Lectures, seminar discussion, and student presentations. Prerequisite: PATH 410 or PATH 444 or HUBIO 520; recommended: ENV H 514; ENV H 515. Offered: Sp, even years.

PATH 560 Molecular Analysis of Human Disease (*, max. 10)
Review and discussion of contemporary research on molecular basis of human disease. Focus on mutational mechanisms, genetic instability, AIDS, and cancer. Students participate in weekly group discussion and work with faculty to select, develop, and present discussion topic. Prerequisite: medical, graduate, or professional standing and permission of instructor. Credit/no-credit only. Offered: AWSp.

PATH 562 P-Cardiovascular Pathology Conference (*) Reichenbach
Consists of two parts: a laboratory review of gross and microscopic cardiovascular pathology of selected autopsied cases followed by a combined clinical (medical and/or surgical) and pathology conference discussing these cases. Prerequisite: HUBIO 540 and permission of instructor.

PATH 590 Patient-Centered Translational Research (1) Horwitz
MSTP students preparing to return to clerkships are partnered with a senior MD/PhD medical student or house office, preview the medical or surgical ward team environment, select a patient-focused translation research topic based on their clinical experience, and prepare a plan for refreshing introductory clinical skills. Offered: WSp.

PATH 600 Independent Study or Research (*-)
Credit/no-credit only.

PATH 667 P-Renal Pathology Laboratory (*, max. 6)
Laboratory elective for third- and fourth-year medical students. Read current literature, review various renal biopsies and urine sediments, and read standard texts prior to a weekly topic-oriented conference. All students earn 1 credit for one-hour seminar per week. May be taken concurrently with MED 693. Prerequisite: permission of instructor.

PATH 676 P-Diagnostic Pathology Clerkship - Spokane (8, max. 24)
Medical student participation in dissection and study of autopsy and surgical pathology cases at Sacred Heart Medical Center in Spokane. Can be taken for either two or four weeks.

PATH 677 P-Neuropathology Clerkship - HMC (*, max. 16)
Includes participation in dissection and study of neuropathology cases. Students work up cases under senior staff including dissection, microscopic examination, and literature review.

PATH 678 P-Diagnostic Pathology Clerkship - Medical Examiner's Office, Alaska (*, max. 24)
Medical student participation in dissection and study of autopsy and forensic pathology cases at the Anchorage Medical Examiner's Office.

PATH 680 P-Diagnostic Pathology Clerkship - University of Washington Medical Center (*, max. 24) Swanson
Medical student participation in dissection and study of autopsy and surgical pathology cases. Cases worked up under senior staff, including dissection, microscopic examination, and literature review. Attendance at pathology conferences and seminars expected. Prerequisite: third- or fourth-year medical student standing.

PATH 681 P-Diagnostic Pathology Clerkship - Harborview Medical Center (*, max. 24)

PATH 682 P-Diagnostic Pathology Clerkship - Veterans' Administration Hospital (*, max. 24)

PATH 683 P-Diagnostic Pathology Clerkship - Medical Examiner's Office (*, max. 24) Raven

PATH 687 P-Diagnostic Pathology Clerkship - Seattle Children's Hospital (*, max. 24)

PATH 688 P-Diagnostic Pathology Clerkship - Madigan Army Medical Center (*, max. 24)

PATH 690 P-Diagnostic Pathology Clerkship - Northwest Medical Center (*, max. 24)

PATH 691 P-Diagnostic Pathology Clerkship - General Hospital of Everett (*, max. 24)

PATH 697 P-Pathology Special Electives (*, max. 24)
By specific arrangement, students have clerkships, externships, or research opportunities at institutions other than the University of Washington. Prospective students obtain special assignment forms from the dean's office at least one month before advance registration. Prerequisite: permission of instructor.

PATH 699 P-WWAMI Pathology Special Electives (*, max. 24)
By special arrangement for qualified students, special clerkships or externships may be available at institutions, other than the University of Washington, located within the WWAMI region. Prerequisite: permission of department.

PATH 700 Master's Thesis (*-)

PATH 800 Doctoral Dissertation (*-)