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SCHOOL OF PHARMACY
MEDICINAL CHEMISTRY

Detailed course offerings (Time Schedule) are available for

MEDCH 400 Fundamental Concepts in Medicinal Chemistry (3) Nelson
Principles of physical organic chemistry; chemical bonding, stereochemistry, acids/bases, and reaction mechanisms relevant to processes such as drug distribution, specificity, and metabolism. Prerequisite: either CHEM 239 or CHEM 337. Offered: A.
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MEDCH 495 Special Studies in Medicinal Chemistry (*, max. 6)
Opportunity to expand the breadth and depth of understanding in specific areas. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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MEDCH 499 Independent Study/Research (*, max. 24)
Research problems in medicinal chemistry. Prerequisite: cumulative GPA of 2.50 and permission of instructor. Offered: AWSpS.
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MEDCH 520 Seminar (1, max. 30) A. NATH
Graduate students attend seminars and make one formal presentation per year while in residence; maximum of three presentations. Credit/no-credit only. Offered: jointly with PCEUT 520.
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MEDCH 521 Advanced Medicinal Chemistry (3) Atkins, Nelson
Application of integrated data from the physical and biological sciences to problems of chemotherapy, including transport of drugs to site of action, biotransformation of drugs, interaction of drugs with enzyme systems, and recent advances in drug design. Prerequisite: CHEM 457, CHEM 531, and BIOC 442, or permission of instructor. Offered: Sp.
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MEDCH 527 Drug Metabolism (4) A. RETTIE, K. THUMMEL
Considerations of the biochemical mechanisms for the biotransformation of drugs and foreign compounds. Includes reaction mechanisms, ultrastructural considerations,induction mechanisms, methodology, kinetics of inhibition and activation, steroid and amine metabolism. Offered: jointly with PHCOL 527; W, odd years.
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MEDCH 528 Biophysical Enzymology and Biopharmaceuticals (3) Atkins, Catalano
Covers in-depth treatment of chemical catalysis and transition state theory as related to enzyme mechanisms; thermodynamics and kinetics of protein-ligand interactions, protein-protein-interactions and protein-lipid interactions, and methods for their study. Discusses therapeutically relevant examples, including viruses, therapeutic antibodies, and drug targets. Offered: W, even years.
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MEDCH 529 Advanced Medicinal Chemistry (4) Atkins, Kunze, Nelson, Rettie, Totah
Covers the fundamental aspects of contemporary medicinal chemistry. Discusses the chemical characteristics of drugs and drug targets, pharmaceutical properties of drugs, drug metabolism, toxicology, and pharmacogenetics. Focuses on various drug classes; their biochemistry, pharmacology, mechanism of action, and toxicology. Offered: W.
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MEDCH 530 Integrated Pharmacology (1) Atkins, Beavo, Rettie
Students present and discuss primary literature that integrates aspects of medicinal chemistry and pharmacokinetics with the physiology, pharmacology, and genetics of therapeutic drug targets. Examples of targets discussed include ion channels and enzymes relevant to cardiovascular disease, and neurodegenerative disease. Credit/no-credit only. Offered: Sp.
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MEDCH 535 P-Diagnostic Medicinal Chemistry (3) Catalano, Kunze
Examination of clinical diagnostic tests with regard to the chemical or biochemical rationale of the testing method, interpretation of test results, and major factors influencing test values with special emphasis on the effects of medications. Clinical laboratory data from patients considered in light of these factors. Offered: W.
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MEDCH 541 Biological Mass Spectrometry (3) Whittington
Covers the basics of modern ionization methods and mass analyzers; small molecule structure assignment, quantitative assay development by LC-MS and metabolomics; quantitative discovery-based proteomics and validation methods; and peptide sequence determination, post-translational modification mapping, and protein structure determination methods. Prerequisite: permission of instructor. Offered: Sp.
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MEDCH 551 Flavin and Heme-Containing Monooxygenases (1) Rettie
Discussion of research strategies and methodologies concerning the structure, function, and polymorphic expression of human monooxygenases, especially the cytochrome P450s and flavin-containing monooxygenases. Emphasis placed on experimental problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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MEDCH 552 Medicinal Chemistry Aspects of Drug Action and Drug Metabolism (1) Nelson
Discussion of research strategies, methodologies, and literature concerning the mechanisms of drug action and drug metabolism, particularly as these apply to opiate drugs and beta blockers. Emphases placed on problem solving, data analysis, and presentation. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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MEDCH 553 Structure and Function of Macromolecular Protein Assemblies (1) Atkins
Discussion of research strategies, methods, and current literature concerning macromolecular self-assembly processes and protein-protein interactions as they relate to biological specificity. Emphasis on experimental approaches used in current literature. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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MEDCH 554 Biophysical and Structural Virology (1) Lee
Discusses current topics in virus research and literature. Weekly sessions led by all participating members of the research group. Credit/no-credit only. Offered: AWSpS.
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MEDCH 555 Biophysics and Pharmacology of Dynamic Proteins (1) Nath
Discusses current topics in protein dynamics, focusing on intrinsically disordered proteins and drug-metabolizing enzymes. Weekly sessions led by all participating members of the research group. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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MEDCH 556 Clinical and Mechanistic Aspects of Drug Metabolism (1) Totah
Discussion of research methodologies and new approaches to elucidatate chemical mechanisms and enzymology of reactions catalyzed by cytochrome P-450. Emphasis on clinical applications and predicting in vivo drug behavior and toxicity. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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MEDCH 558 Human Cytochrome P-450 Biochemistry (1) Kunze
Presentation and discussion of research strategies and methodologies related to current problems in human drug metabolism by cytochrome P-450 enzymes. Emphasis on hypothesis testing and experimental problem solving in the areas of enzyme kinetics and mechanism. Prerequisite: permission of instructor. Credit/no-credit only. Offered: AWSpS.
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MEDCH 559 Molecular Motors (1) Catalano
Discussion of molecular motors, particularly those associated with virus assembly pathways. Emphasizes kinetic, biochemical, and biophysical approaches to dissect the molecular mechanisms of motor function. Offered: AWSpS.
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MEDCH 561 P-Immunizing and Antimicrobial Agents (4) Black, Lee, Totah
Mechanisms of action, spectrum of coverage, resistance patterns, toxicity, and therapeutic applications of antibiotics, antifungals, and antivirals. Also covering chemical and biologic properties of agents used to prevent or treat infectious diseases, including diagnostic, prophylactic, and therapeutic uses of immunizing agents. Prerequisite: MICROM 301, MICROM 302, MEDCH 570, or equivalent, PharmD major, or permission of instructor. Offered: Sp.
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MEDCH 562 P-Medicinal Chemistry (3) W. ATKINS, K. KUNZE, D. PORUBEK, A. RETTIE
Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: A.
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MEDCH 563 P-Medicinal Chemistry (3) Nelson, Rettie
Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: W.
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MEDCH 564 P-Medicinal Chemistry (3) Atkins, Nelson
Study of the various classes of medicinal compounds with particular emphasis on biological activity, mechanism of action, biotransformation, and the structural and physical properties governing absorption, distribution, and excretion. Prerequisite: MEDCH 400 or satisfactory completion of qualifying exam. Offered: Sp.
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MEDCH 570 P-Medicinal Biochemistry (4) Catalano, Kunze
Covers advanced topics in medical biochemistry directly related to understanding disease and drug therapy in pharmacy practice. Areas of study include enzymes of drug metabolism, metabolic control of disease states, signal transduction, virology, coagulation and complement cascades, cellular transport, and DNA replication/transcription. Offered: W.
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MEDCH 582 Topics in Medicinal Chemistry (1, max. 30)
Discussion of pertinent articles from current literature. Credit/no-credit only. Offered: AWSp.
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MEDCH 599 Cumulative Exams for Medicinal Chemistry (1)
Quarterly cumulative examinations for graduate students. Credit/no-credit only. Offered: AWSp.
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MEDCH 600 Independent Study or Research (*-)
Credit/no-credit only. Offered: AWSpS.
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MEDCH 700 Master's Thesis (*-)
Credit/no-credit only. Offered: AWSpS.
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MEDCH 800 Doctoral Dissertation (*-)
Credit/no-credit only. Offered: AWSpS.
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