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Course Descriptions

SCHOOL OF PUBLIC HEALTH
EPIDEMIOLOGY

Detailed course offerings (Time Schedule) are available for

To see the detailed Instructor Class Description, click on the underlined instructor name following the course description.

EPI 405 Phys Activity in Health and Disease (3) Duncan
Impact of physical activity on individual and public health. Overview of physiological adaptations to activity, exercise prescription, exercise epidemiology, and prevention of chronic diseases. Public health recommendations for activity in the U.S. population, and the effects of the built environment on activity. Prerequisite: BIOL 118. Offered: jointly with NUTR 405; Sp.
Instructor Course Description: Glen E Duncan

EPI 420 Introduction to Epidemiology (3) NW Goldberg
For the undergraduate student wishing to devote only one quarter to a course in epidemiologic methods. Description of ways in which variation in disease occurrence is documented and how that variation is studied to understand causes of disease. Offered: Sp.
Instructor Course Description: Jack Goldberg

EPI 497 Epidemiology Special Electives (*)
Off-campus course for medical students. Offered: AWSpS.

EPI 499 Undergraduate Research (*)
Offered: AWSpS.

EPI 502 Phys Activity in Health and Disease (3) Duncan
Impact of physical activity on individual and public health. Overview of physiological adaptations to activity, exercise prescription, exercise epidemiology, and prevention of chronic diseases. Public health recommendations for activity in the U.S. population, and the effects of the built environment on activity. Prerequisite: BIOL 118. Offered: jointly with NUTR 505; Sp.
Instructor Course Description: Glen E Duncan

EPI 503 Public Health Informatics and Surveillance (3)
Covers collection and use of public health surveillance data in formulating policy and managing programs through lectures and real-world interactive exercises. Discusses surveillance for birth defects, environmental exposures, and hospital-acquired infections, and use of tools such as small area analysis and geographic information systems. Offered: jointly with HSERV 503.

EPI 507 HIV and STIs in Women and Children (3) Stewart
Examines the emerging global public health crisis and the plight of women and children with HIV/STIs. Reviews targeted approaches pertaining to women and children and their vulnerability to HIV/STIs. Prerequisite: EPI 511 or EPI 512-513. Offered:jointly with OB GYN 590; Sp.

EPI 510 Epidemiologic Data Analysis (2) Hawes, Winer
Intended for students planning to take 514. Introduces concepts and programming skills necessary to analyze data sets for case-control and cohort studies. Provides students hands-on experience in using epidemiologic data sets for stratified analyses with SAS and Stata. Credit/no credit only. Prerequisite: EPI 511 or EPI 512. Offered: W.
Instructor Course Description: Stephen E. Hawes

EPI 511 Introduction to Epidemiology (4) Kukull
Epidemiologic methods for non-epidemiology majors. Focuses on research designs and methods to describe disease occurrence and risk factor associations; uses quantitative and biomedical information to infer whether causal relationships exist between potential causes and disease in populations. Offered: A.
Instructor Course Description: Walter A Kukull

EPI 512 Epidemiologic Methods I (4) Holt, Koepsell, Weiss
Principles and methods of epidemiology. Covers measures of disease frequency, measures of effect, causal inferences, descriptive epidemiology, study types, misclassification, and effect modification. Designed for students who want to take 513. Prerequisite: prior or concurrent enrollment in BIOST 511 or equivalent. Offered: A.
Instructor Course Description: Thomas D Koepsell

EPI 513 Epidemiologic Methods II (4) Holt, Koepsell, Weiss
Continuation of 512. Considers how designs of epidemiologic studies may be constructed to maximize etiologic inferences. Covers confounding, randomized trials, cohort studies, case-control studies, and selected topics. Prerequisite: EPI 512. Offered: W.
Instructor Course Description: Victoria L. Holt

EPI 514 Application of Epidemiologic Methods (4) Hawes, Mueller
Practical experience in analysis of data. Students analyze data sets currently on file using contemporary epidemiologic methods as taught in 512 and 513. Prerequisite: EPI 510 or experience in statistical programming; EPI 512, EPI 513 and epidemiology major. Offered: Sp.
Instructor Course Description: Beth A. Mueller

EPI 515 Topics in Epidemiologic Methods (3)
Introduces advanced methodologic methods, including recursive partitioning, developing clinical prediction rules, analyses of community-level associations or interventions, case-crossover and case-only designs, propensity scores, two-stage sampling, and missing data imputation. Prerequisite: EPI 512; EPI 513. Offered: jointly with BIOST 519; A.
Instructor Course Description: Anneclaire Jenice De Roos

EPI 516 Statistical Methods in Genetic Epidemiology (3)
Theory and application of statistical techniques used in genetic epidemiology. Includes discussion of association studies, linkages and segregation analyses. Examples stressed with reference to assumptions and limitations. Prerequisite: either BIOST 513 or BIOST 518; PHG 511/EPI 517; or permission of instructor. Offered: jointly with BIOST 516/PHG 519.

EPI 517 Genetic Epidemiology (3) Austin
Research methods for evaluating genetic influences on disease and risk factors and genetic-environmental interactions. Study designs and statistical methods include twin studies, family studies, population-based association studies, segregation analysis, and linkage analysis. Prerequisite: EPI 511, BIOST 511, and GENET 371, or equivalent. Offered: jointly with PHG 511; Sp.

EPI 518 Computer Demonstrations in Genetic Epidemiology (2-4, max. 4) Edwards
Demonstrations and use of computer programs designed specifically for analysis of genetic epidemiologic data, including heritability, segregation, and sib-pair linkage analysis. Discussions focus on interpretation of results. Laboratory sections apply methods to data provided by instructor. Corequisite: EPI 517/PHG 511 or permission of instructor. Offered: jointly with PHG 518.

EPI 519 Epidemiology of Cardiovascular Disease (3) Psaty, Siscovick
Principles, methods, and issues in the epidemiology of cardiovascular disease. Focuses on coronary heart disease and its major risk factors; also covers other topics such as stroke and sudden death. The format includes informal lectures and discussions of the current literature. Prerequisite: EPI 511 or EPI 512, EPI 513. Offered: A.
Instructor Course Description: Bruce M. Psaty

EPI 520 Epidemiology of Infectious Diseases (3) Manhart
Infectious diseases from a public health perspective. Topics include analytic methods, study design, outbreak investigations, surveillance, vaccine evaluations, global eradication, screening, modeling, and infectious causes of chronic diseases. Homework and discussion based on current examples from the published literature. Prerequisite: EPI 511, EPI 512, or permission of instructor. Offered: W.
Instructor Course Description: Lisa E. Manhart

EPI 521 Epidemiology of Maternal and Child Health Problems ([3-4]-, max. 4) Williams
Contributions to understanding and prevention of major maternal and child health problems, including pregnancy outcome, infant and child morbidity and mortality, maternal morbidity and mortality, abnormal child growth and development, and early-life factors in adult health problems. Prerequisite: graduate, medical, or dental school standing and EPI 511 or EPI 512 or permission of instructor. Offered: jointly with HSERV 542; W.
Instructor Course Description: Michelle A. Williams

EPI 522 Reproductive Epidemiology (3) Holt
Focuses on female reproductive system conditions and diseases,, non-birth pregnancy outcomes,, and impact of pregnancy on later health. Presentation of current epidemiologic knowledge and discussion of methodologic issues on topics including the menstrual cycle; contraception; infertility; spontaneous and induced abortion; and uterine and ovarian disease. Prerequisite: either EPI 511, both EPI 512 and EPI 513, or permission of instructor. Offered: even years; Sp.
Instructor Course Description: Victoria L. Holt

EPI 524 Epidemiologic Studies of Cancer Etiology and Prevention (3/4) Li, Rossing
Current knowledge of the role of environmental/lifestyle factors and genetic susceptibility in the etiology of several cancers with an emphasis on study design. Prerequisite: either EPI 511 or EPI 512; concurrent enrollment in EPI 513. Offered: W.
Instructor Course Description: Christopher I-Fu Li

EPI 526 Epidemiology of Diseases Communicable from Nature (3) DiGiacomo, Rausch, Weigler
Explores the public health aspects of zoonotic diseases, their epidemiology and approaches to control. Focuses on the major viral, rickettsial, bacterial, protozoal, helminthic, and fungal diseases transmitted from wild and domesticated animals to humans. Prerequisite: EPI 511, EPI 512, or EPI 520 or permission of instructor. Offered: jointly with C MED 526; Sp.
Instructor Course Description: Ronald F. Di Giacomo

EPI 527 Vaccines (3) Wald
Overview of issues in vaccine development, clinical trials, implementation of vaccination programs, and the role of vaccines in the control of infectious diseases. Emphasizes current issues and real-world challenges in the vaccine field and features critical reading of the literature. Prerequisite: either EPI 511, EPI 512, or EPI 513. Offered: A.
Instructor Course Description: Anna Wald

EPI 528 Exposure Measurement in Epidemiology (3) White
Principles and methods of measuring exposures (risk factors) in epidemiological studies. Questionnaire design; quality-control procedures for interviews, record abstraction, and lab methods;validity and reliability of measures,;effects of measurement error; maximizing response rates; measurement of specific exposures. Credit/no credit only. Prerequisite: EPI 513. Offered: Sp.
Instructor Course Description: J Emily White

EPI 529 Emerging Infections of International Public Health Importance (3-, max. 3) Kimball
Focuses on the nexus between emerging infections and increasing globalization of the world due to the mobility of people and goods. Examines emergent events through risk factors and associated macro changes implicated in their genesis. Reviews microbial evolutionary strategies and factors of emergence. Offered: jointly with HSERV 536; in residence, odd years; online, even years; W.

EPI 530 AIDS: A Multidisciplinary Approach (2) Farquhar
Comprehensive overview of the public health, clinical, and laboratory aspects of human immunodeficiency virus (HIV) infection and disease. Topics include the pathogenesis, natural history, and management of HIV infections. The impact of HIV/AIDS on community and global health care and prospects for prevention and control. Credit/no credit only. Offered: jointly with MED 530/G H 562; A.
Instructor Course Description: Carey Farquhar

EPI 532 Epidemiology of Infectious Diseases in Resource-Limited Countries (3) McClelland
A review of major infectious disease problems of the developing world, including AIDS, malaria, tuberculosis, measles, and diarrhea, with an emphasis on public health control strategies. Offered: odd years.
Instructor Course Description: Raymond Scott Mcclelland

EPI 533 Pharmacoepidemiology (3) Heckbert, Johnson
Overview of pharmacoepidemiology including drug development and approval; application of epidemiologic methods to study drug safety and effectiveness; exploration of the interplay between research and public policy; introduction to resources for information about drugs; introduction to pharmacology principles pertinent to pharmacoepidemiology. Prerequisite: health sciences graduate student or with permission. Offered: jointly with PHARM 533; even years; Sp.
Instructor Course Description: Susan R. Heckbert

EPI 534 Principles of Publishing Clinical Evidence (2) Johnson, Olson
Explains advanced methodologic principles for improving the clarity of published clinical evidence. Students prepare and revise a 1000-word research letter for The Lancet using their own clinical evidence. Credit/no credit only. Prerequisite: permission of instructor. Offered: jointly with PHARM 536; Sp.

EPI 536 Categorical Data Analysis in Epidemiology (4)
Summary of univariate categorical data analysis; introduction to multivariate analysis of categorical epidemiologic data using multiplicative models. Experience at interpretation; familiarity with available programs gained by analysis of bona fide data, critiques of analyses appearing in literature. Prerequisite: BIOST 515; EPI 513 and either BIOST 513 or BIOST 518; or permission of instructor. Offered: jointly with BIOST 536; A.
Instructor Course Description: Norman Breslow

EPI 537 Survival Data Analysis in Epidemiology (4)
Introduction to the multivariate analysis of survival data using multiplicative models. Application to epidemiologic studies. Familiarity with interpretation and available computer programs gained by analysis of bona fide sets of data and critiques of analyses appearing in the literature. Prerequisite: EPI 536 or permission of instructor. Offered: jointly with BIOST 537;W.
Instructor Course Description: Norman Breslow

EPI 538 Nutritional Epidemiology (3) Beresford
Application of epidemiological methods to current studies of diet, nutrition, and chronic disease. A discussion of current issues and controversies enable students to plan studies in nutritional epidemiology and disease prevention. Prerequisite: EPI 511 or EPI 512 or permission of instructor. Offered: jointly with NUTR 538; A.
Instructor Course Description: Shirley A. Beresford

EPI 539 Research Methods in Developing Countries (3/4) Gloyd, Mock
Simple, practical methodologies to obtain and validate information regarding health status and health services in developing countries. Usefulness, validity, limitation of vital records, health reports, household (and cluster) surveys, nutritional anthropometry, and qualitative methods discussed. Lectures, computer lab, and student participation in community-based survey. Offered: jointly with G H 531; W.

EPI 540 Introduction to Cancer Biology (3) Madeleine
Provides a general understanding of cancer biology, covering the carcinogenic process and various biological causes of cancer. Integrates knowledge from different fields of cancer research, guiding students through diverse literature on cancer and carcinogenesis. Prerequisite: GENOME 371, BIOL 355, or permission of instructor. Offered: even years; Sp.
Instructor Course Description: Margaret M. Madeleine

EPI 541 Introduction to Systematic Reviews and Meta-analysis of Evidence (3) Wolf
Conceptual understanding of the quantitative methods used to synthesize evidence. Methods for pooling evidence across independent studies, pooling binary/continuous outcomes, differences between fixed and random effects models, and guidelines for appraising published systematic reviews/meta-analyses. Prerequisite: introductory-level courses in statistics, epidemiology, or biostatistics. Offered: jointly with MEBI 541/HSERV 529; Sp.

EPI 542 Clinical Epidemiology (2) Weiss
Principles and methods involved in studying the outcome of illness. Prerequisite: EPI 511, or EPI 512 and EPI 513. Offered: S.
Instructor Course Description: Noel S Weiss

EPI 546 Psychiatric Epidemiology (3) Vander Stoep
Applies epidemiological methods to the study of mental illnesses. Topics include occurrence and distribution of mental illness, classification of psychiatric disorders; treatment-based vs. community-based studies; epidemiology of depression and schizophrenia; familial transmission; developmental epidemiology; mental illness and violence. Credit/no credit only. Prerequisite: either EPI 511, EPI 512, HSERV 591, or permission of instructor. Offered: jointly with PBSCI 546; Sp.
Instructor Course Description: Ann Vander Stoep

EPI 547 U.S. Health and Health Care: Population Health, Social Determinants, and Health Disparities (3)
Explores the elements and actions of a population health approach, including conceptualizing the determinants of health, synthesizing knowledge about major social determinants, and applying knowledge to improve population health and reduce health disparities. Enrollment priority for Health Services PhD students. Prerequisite: HSERV 511, and permission of instructor; recommended: HSERV 512. Offered: jointly with HSERV 513; Sp.

EPI 548 Social Determinants of Health Research Methods (3) Beresford, Smith
Explores study design, measurement and analytic issues applicable to research into the social determinants of health. Semi-weekly graduate-level seminar offered to students with a basic knowledge of epidemiological and biostatistical principles. Prerequisite: either EPI 511 or EPI 512/EPI 513; BIOST 511/BIOST 512 or BIOST 517/BIOST 518. Offered: jointly with HSERV 548; W.
Instructor Course Description: Nicholas L Smith

EPI 549 Sociobehavioral and Prevention Research Methods for HIV and STI (3) Kurth
Focuses on prevention methods for controlling HIV/STI epidemics, identifying a range of alternatives along the prevention continuum as most appropriate and feasible for settings and populations, and solutions to increase HIV/STI prevention agenda in public health and clinical policy and practice. Offered: jointly with NMETH 515; Sp.

EPI 555 Statistical Methods for Spatial Epidemiology (3) Wakefield
Motivates the need for, and describes methods for the analysis of spatially indexed epidemiological data. Covers four major topics: clustering and cluster detection, disease mapping, spatial regression, and an introduction to geographical information systems. Considers both point-references and spatially aggregated data. Offered: jointly with BIOST 555.

EPI 568 Molecular Epidemiology of Infectious Diseases (2) DiGiacomo, Roberts
Application of molecular typing techniques to study of microbial pathogens to increase understanding of epidemiology of infectious diseases. Brief review of molecular biology. Evaluation of methods used in outbreaks and epidemics reported in literature. Prerequisite: EPI 511 or EPI 512 or permission of instructor. Offered: jointly with ENV H 568/PABIO 568. Offered: W.
Instructor Course Description: Ronald F. Di Giacomo

EPI 570 Occupational and Environmental Epidemiology (3) Checkoway
Research methods for studying occupational and environmental determinants of disease. Defining exposed populations, characterizing exposure levels, estimating disease risks relative to exposure. Cohort, case-control, cross-sectional designs for various health outcomes. Applications to exposure standard setting and risk assessment. Prerequisite: EPI 511 or EPI 512, EPI 513 or permission of instructor. Offered: jointly with ENV H 570; Sp.

EPI 571 Neuroepidemiology and Environmental Risk Factors (3) Kukull
Focus on neurologic diseases and etiology. Presentation of descriptive epidemiology, clinical features, and risk factors, including stroke, Parkinson's disease, Alzheimer's disease, multiple sclerosis, and other disorders. Discussion of NIH grantsmanship. Guest experts present some topics. Recommended: EPI 511 or equivalent. Offered: jointly with ENV H 571; odd years; W.
Instructor Course Description: Walter A Kukull

EPI 573 Methods and Issues in Using Biological Measurements in Epidemiologic Research (3) Schwartz
Introduction to use of measurements from biological specimens in epidemiologic studies. Prepares epidemiology and laboratory science students for conduct of interdisciplinary human studies. Evaluation of biomarkers, preliminary studies, methodologic issues, quality control. Brief review of molecular biology. Applications and current literature discussed. Prerequisite: EPI 511 or EPI 512. Offered: jointly with ENV H 573.
Instructor Course Description: Stephen Marc Schwartz

EPI 583 Epidemiology Seminar (1, max. 12)
Presentation of current epidemiologic research and application of epidemiologic research in the practice of public health. Offered: AWSp.

EPI 584 Doctoral Dissertation Seminar (1) Davis, Holt
Forum for Epidemiology doctoral students to obtain information for doctoral research, including: project ideas; forming a committee; developing a proposal; conducting the project; and presenting results. Prerequisite: Epidemiology 512 and513, admitted to the PhD program, passed the Preliminary Examination or 2nd year status.
Instructor Course Description: Scott Davis

EPI 585 Principles of Injury Research and Prevention (3) Schiff
Focuses on broad concepts including a conceptual model, surveillance, research methods, control and prevention of injuries. Topics include unintentional injuries from motor vehicle crashes, falls, drowning, sports injuries and intentional injuries from youth violence, intimate partner violence, homicide and suicide. Recommended: EPI 511. Offered: A.
Instructor Course Description: Melissa A Schiff

EPI 586 Responsible Conduct of International Research (3) Farquhar
Prepares international and U.S. students to develop research proposals, conduct international field research, and present scholarly work. Topics include proposal writing, human subjects protection, data management, peer review, scholarly integrity, responsible authorship, and grants and budget management. Open to graduate and non-matriculated students. Credit/no credit only. Offered: jointly with G H 532; A.

EPI 587 Practical Aspects of Research Operations (2) Fitzpatrick
Provides the basics necessary to plan, implement, and manage a research study. Topics include human subjects applications, data collection, hiring and training of staff, participant recruitment and retention, data management, quality assurance and control, results reporting, communications, and budgeting. Prerequisite: K12 Clinical Scholar or one course in EPI/BIOST. Credit/no credit only. Offered: A.
Instructor Course Description: Annette L. Fitzpatrick

EPI 588 Preparing and Writing Research Proposals (2) Kristal, Reiber
Experience in preparing, organizing, and writing research proposals, following NIH and AHRQ guidelines. Includes weekly assignments and didactic exercises, leading to final research proposal. All students participate in mock study section to review and critique proposals. Credit/no credit only. Prerequisite: second-year graduate student (PhD recommended), or PhD or MD in health-related field. Offered: A.

EPI 590 Selected Topics in Epidemiology or International Health (1-6, max. 6)
Tutorials are arranged for a small number of students for in-depth examination of an area of epidemiology or international health, usually of current nature. Seminar format. Prerequisite: EPI 511. Also a special summer format presenting introductory material. May be offered with ENV H 590 and/or HSERV 590. For more information and permission, consult the department program adviser. Offered: AWSpS.
Instructor Course Description: Stephen Marc Schwartz

EPI 591 Current Literature in Epidemiology (1, max. 6)
Articles pertaining to epidemiology and related subjects selected from the current literature to be distributed and read by all participants. Faculty members and enrolled students alternate being responsible for conducting sessions and choosing articles to read. Credit/no credit only. Prerequisite: EPI 513. Offered: AWSp.

EPI 592 Program Seminars (1-6, max. 6)
Graduate seminars organized to address specific educational needs of students in various specialized programs within the Department of Epidemiology (i.e., Maternal and Child Health). Prerequisite: permission of instructor. Offered: AWSpS.

EPI 593 Cancer Prevention Research Laboratory (3) White
Research experience for pre- and postdoctoral students working on cancer prevention projects at the Fred Hutchinson Cancer Research Center. Credit/no credit only. AWSpS.

EPI 595 Epidemiology Master's Practicum (1-6, max. 6)
Supervised practice experience providing students an opportunity to learn how epidemiology is applied in a public health setting and in the formulation and application of public health policy. Credit/no credit only. Prerequisite: EPI 512 and BIOST 511 or equivalent and permission of instructor. Offered: AWSpS.

EPI 600 Independent Study or Research (*)
Credit/no credit only. Prerequisite: permission of departmental adviser and independent study supervisor. Offered: AWSpS.

EPI 700 Master's Thesis (*)
Credit/no credit only. Prerequisite: permission of thesis chair. Offered: AWSpS.

EPI 800 Doctoral Dissertation (*)
Credit/no credit only. Prerequisite: permission of dissertation chair. Offered: AWSpS.