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SCHOOL OF PUBLIC HEALTH
EPIDEMIOLOGY

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EPI 320 Introduction to Epidemiology (3) NW Goldberg
For the undergraduate student wishing to devote only one quarter to a course in epidemiologic methods. Description of ways in which variation in disease occurrence is documented and how that variation is studied to understand causes of disease. Prerequisite: either BIOST 310, QMETH 201, Q SCI 381, STAT 220, STAT/CS&SS/SOC 221, or STAT 311, any of which may be taken concurrently. Offered: WSp.

EPI 499 Undergraduate Research (*)
Offered: AWSpS.

EPI 501 Public Health Practice at the Local Level (3)
Basic overview of state and local public health practice with leaders in the field and case studies focusing on rural and urban public health challenges. Offers preparation for practice in public health agencies. Prerequisite: HSERV 511 or permission of instructor. Offered: jointly with HSERV 501.

EPI 502 Phys Activity in Health and Disease (3) Duncan
Impact of physical activity on individual and public health. Overview of physiological adaptations to activity, exercise prescription, exercise epidemiology, and prevention of chronic diseases. Public health recommendations for activity in the U.S. population, and the effects of the built environment on activity. Prerequisite: either BIOL 118 or BIOL 180. Offered: jointly with NUTR 505; Sp.
Instructor Course Description: Glen E Duncan

EPI 503 Applied Epidemiology in Public Health Practice (3) Baseman
Introduces the principles, methods, and issues in public health practice-based epidemiology. Covers public health surveillance, outbreak and cluster investigation, community health assessment, screening, evaluation, and other select topics. Offered: jointly with HSERV 503; Sp.
Instructor Course Description: Janet G. Baseman

EPI 504 Health Needs Assessment (3)
Covers key methods and principles for needs assessment and is recommended for students who plan to monitor and measure the health of populations, plan health services, or make decisions about health resource distribution. Offered: jointly with HSERV 530.

EPI 505 Preventing Healthcare Associated Infections (1) Lynch
Multidisciplinary approach to understanding, measuring, and developing policy to prevent healthcare associated infections. Credit/no-credit only. Offered: jointly with MED 540; W.

EPI 507 HIV and STIs in Women and Children (3) John-Stewart
Examines the emerging global public health crisis and the plight of women and children with HIV/STIs. Reviews targeted approached pertaining to women and children and their vulnerability to HIV/STIs. Offered: jointly with G H 564/OB GYN 590; Sp.

EPI 510 Epidemiologic Data Analysis (3) Hawes, Winer
Intended for students planning to take EPI 514. Introduces concepts and programming skills necessary to analyze data sets for case-control and cohort studies. Provides students hands-on experience in using epidemiologic data sets for stratified analyses with SAS and Stata. Prerequisite: EPI 511 or EPI 512. Credit/no-credit only. Offered: W.
Instructor Course Description: Stephen E. Hawes

EPI 511 Introduction to Epidemiology (4) Kukull
Epidemiologic methods for non-epidemiology majors. Focuses on research designs and methods to describe disease occurrence and risk factor associations; uses quantitative and biomedical information to infer whether causal relationships exist between potential causes and disease in populations. Offered: A.
Instructor Course Description: Walter A Kukull

EPI 512 Epidemiologic Methods I (4) Holt, Rowhani, Weiss
Considers principles and methods of epidemiology. Covers measures of disease frequency, descriptive epidemiology, overview of study designs, measures of excess risk, causal inference, screening, measurement error, misclassification, effect modification, and confounding. First in a two course sequence. Prerequisite: BIOST 511, which may be taken concurrently, or equivalent. Offered: A.
Instructor Course Description: Victoria L. Holt

EPI 513 Epidemiologic Methods II (4) Holt, Rowhani, Weiss
Considers how epidemiologic studies may be designed to maximize etiologic inference. Covers infectious disease epidemiologic studies, randomized controlled trials, cohort studies, case-control studies, cross-sectional studies, ecological and multilevel studies, and selected topics such as meta-analysis. Second in a two course sequence. Prerequisite: EPI 512. Offered: W.
Instructor Course Description: Ali Rowhani-Rahbar

EPI 514 Application of Epidemiologic Methods (4) Hawes, Mueller
Practical experience in analysis of data. Students analyze data sets currently on file using contemporary epidemiologic methods as taught in EPI 512 and EPI 513. Prerequisite: EPI 510 or experience in statistical programming; EPI 512, EPI 513, and epidemiology major. Offered: Sp.
Instructor Course Description: Beth A. Mueller

EPI 515 Advanced Epidemiologic Methods (4) Guthrie, Phipps
Introduces advanced epidemiologic methods, including causal modeling, inverse probability weighting, propensity scores, sensitivity analysis, imputation for missing data, approaches to multiple comparisons, Bayesian adjustment of risk estimates, recursive portioning, and modeling for prediction. Prerequisite: EPI 512; EPI 513; EPI 514; EPI 536/BIOST 536. Offered: jointly with BIOST 519; Sp.
Instructor Course Description: Amanda I Phipps

EPI 516 Statistical Methods in Genetic Epidemiology (3)
Theory and application of statistical techniques used in genetic epidemiology. Includes discussion of association studies, linkages and segregation analyses. Examples stressed with reference to assumptions and limitations. Prerequisite: either BIOST 513 or BIOST 518; PHG 511/EPI 517; or permission of instructor. Offered: jointly with BIOST 516/PHG 519.

EPI 517 Genetic Epidemiology (3) Fullerton
Research methods for evaluating genetic influences on disease and risk factors and genetic-environmental interactions. Study designs and statistical methods include twin studies, family studies, population-based association studies, segregation analysis, and linkage analysis. Prerequisite: EPI 511, BIOST 511, and GENOME 371, or equivalent. Offered: jointly with PHG 511; Sp.

EPI 518 Computer Demonstrations in Genetic Epidemiology (2/4, max. 4) Karen Edwards
Demonstrations and use of computer programs designed specifically for analysis of genetic epidemiologic data, including heritability, segregation, and sib-pair linkage analysis. Discussions focus on interpretation of results. Laboratory sections apply methods to data provided by instructor. Offered: jointly with PHG 518; Sp.

EPI 519 Epidemiology of Cardiovascular Disease (3) Psaty, Siscovick
Principles, methods, and issues in the epidemiology of cardiovascular disease. Focuses on coronary heart disease and its major risk factors; also covers other topics such as stroke and sudden death. The format includes informal lectures and discussions of the current literature. Prerequisite: EPI 511 or EPI 512, EPI 513. Offered: A.
Instructor Course Description: Bruce M. Psaty

EPI 520 Epidemiology of Infectious Diseases (3) Manhart
Infectious diseases from a public health perspective. Topics include analytic methods, study design, outbreak investigations, surveillance, vaccine evaluations, global eradication, screening, modeling, and infectious causes of chronic diseases. Homework and discussion based on current examples from the published literature. Prerequisite: EPI 511, EPI 512, or permission of instructor. Offered: W.
Instructor Course Description: Lisa E. Manhart

EPI 521 Epidemiology of Maternal and Child Health Problems ([3-4]-) Enquobahrie
Contributions to understanding and prevention of major maternal and child health problems, including pregnancy outcome, infant and child morbidity and mortality, maternal morbidity and mortality, abnormal child growth and development, and early-life factors in adult health problems. Prerequisite: graduate, medical, or dental school standing and EPI 511 or EPI 512 or permission of instructor. Offered: jointly with HSERV 542; W.
Instructor Course Description: Daniel Asmama Enquobahrie

EPI 522 Reproductive Epidemiology (3) Holt
Focuses on female reproductive system conditions and diseases, non-birth pregnancy outcomes, and impact of pregnancy on later health. Presentation of current epidemiologic knowledge and discussion of methodologic issues on topics including the menstrual cycle; contraception; infertility; spontaneous and induced abortion; and uterine and ovarian disease. Prerequisite: either EPI 511, both EPI 512 and EPI 513, or permission of instructor. Offered: Sp, even years.
Instructor Course Description: Victoria L. Holt

EPI 524 Epidemiologic Studies of Cancer Etiology and Prevention (3/4) Li
Current knowledge of the role of environmental/lifestyle factors and genetic susceptibility in the etiology of several cancers with an emphasis on study design. Prerequisite: either EPI 511 or EPI 512; concurrent enrollment in EPI 513. Offered: W.
Instructor Course Description: Christopher I-Fu Li

EPI 527 Vaccines (3) Wald
Overview of issues in vaccine development, clinical trials, implementation of vaccination programs, and the role of vaccines in the control of infectious diseases. Emphasizes current issues and real-world challenges in the vaccine field and features critical reading of the literature. Prerequisite: either EPI 511, EPI 512, or EPI 513. Offered: A.
Instructor Course Description: Anna Wald

EPI 528 Exposure Measurement in Epidemiology (3) J. DELANEY
Principles and methods of measuring exposures (risk factors) in epidemiological studies. Questionnaire design; quality-control procedures for interviews, record abstraction, and lab methods; validity and reliability of measures; effects of measurement error; maximizing response rates; measurement of specific exposures. Prerequisite: EPI 513. Credit/no-credit only. Offered: Sp.
Instructor Course Description: Joseph A. Delaney

EPI 529 Emerging Infections of International Public Health Importance (3-)
Focuses on the nexus between emerging infections and increasing globalization of the world due to the mobility of people and goods. Examines emergent events through risk factors and associated macro changes implicated in their genesis. Reviews microbial evolutionary strategies and factors of emergence. Prerequisite: graduate standing. Offered: jointly with HSERV 536.
Instructor Course Description: John B. Lynch

EPI 530 AIDS: A Multidisciplinary Approach (2) Farquhar
Comprehensive overview of the public health, clinical, and laboratory aspects of human immunodeficiency virus (HIV) infection and disease. Topics include the pathogenesis, natural history, and management of HIV infections. The impact of HIV/AIDS on community and global healthcare and prospects for prevention and control. Credit/no-credit only. Offered: jointly with G H 562/MED 530; A.
Instructor Course Description: Carey Farquhar

EPI 531 Statistical Methods for Analysis with Missing Data (3) Chan
Covers statistical methods for the analysis of missing data, including likelihood-based, weighted GEE, multiple imputation, and Bayesian approaches. Uses computational tools such as EM algorithm and Gibbs' sampler. Covers both ignorable and non-ignorable missing-data mechanisms as well as cross-sectional and longitudinal study designs. Primarily uses data arising from epidemiologic studies. Offered: jointly with BIOST 531; W.

EPI 532 Epidemiology of Infectious Diseases in Resource-Limited Countries (3) McClelland
A review of major infectious disease problems of the developing world, including AIDS, malaria, tuberculosis, measles, and diarrhea, with an emphasis on public health control strategies.
Instructor Course Description: Raymond Scott Mcclelland

EPI 533 Pharmacoepidemiology (3) Boudreau, Heckbert
Overview of pharmacoepidemiology including drug development and approval; application of epidemiologic methods to study drug safety and effectiveness; exploration of the interplay between research and public policy; introduction to resources for information about drugs; introduction to pharmacology principles pertinent to pharmacoepidemiology. Prerequisite: Health Sciences graduate student; either EPI 511 or both EPI 512 and EPI 513; or permission of instructor. Offered: jointly with PHARM 533; Sp, even years.
Instructor Course Description: Susan R. Heckbert

EPI 536 Categorical Data Analysis in Epidemiology (4)
Summary of univariate categorical data analysis; iIntroduction to multivariate analysis of categorical epidemiologic and health sciences data using multiplicative models. Experience at interpretation; familiarity with available softwareprograms gained by analysis of bona fide data and critiques of published analyses appearing in literature. Prerequisite: BIOST 515; EPI 513 and either BIOST 513 or BIOST 518; or permission of instructor. Offered: jointly with BIOST 536; A.
Instructor Course Description: Norman Breslow

EPI 537 Survival Data Analysis in Epidemiology (4)
Introduction to multivariate analysis of survival data using multiplicative models. Application to epidemiologic and health sciences studies. Familiarity with interpretation and available softwarecomputer programs gained by analysis of bona fide sets of data and critiques of published analyses appearing in the literature. Prerequisite: BIOST 536 or permission of instructor. Offered: jointly with BIOST 537; W.
Instructor Course Description: Norman Breslow

EPI 538 Nutritional Epidemiology (3) Beresford
Application of epidemiological methods to current studies of diet, nutrition, and chronic disease. A discussion of current issues and controversies enables students to plan studies in nutritional epidemiology and disease prevention. Prerequisite: EPI 511 or EPI 512 or permission of instructor. Offered: jointly with NUTR 538; A.
Instructor Course Description: Shirley A. Beresford

EPI 539 Research and Evaluation Methods in Global Health (3/4) Mock, O'Malley
Provides an overview of a range of evaluation and research designs used in global health. Students learn practical methodologies to obtain, validate, and analyze information regarding health status, services, and programs. Discusses usefulness, validity, limitation of vital records, health reports, household (and cluster) surveys, and qualitative methods. Offered: jointly with G H 531; W.

EPI 540 Introduction to Cancer Biology (3) Madeleine
Provides a general understanding of cancer biology, covering the carcinogenic process and various biological causes of cancer. Integrates knowledge from different fields of cancer research, guiding students through diverse literature on cancer and carcinogenesis. Prerequisite: undergraduate biology coursework or permission of instructor. Offered: Sp, even years.
Instructor Course Description: Margaret M. Madeleine

EPI 541 Introduction to Systematic Reviews and Meta-Analysis of Evidence (3) E. DEVINE, F. WOLF
Conceptual understanding of the quantitative methods used to synthesize evidence. Methods for pooling evidence across independent studies, pooling binary/continuous outcomes, differences between fixed and random effects models, and guidelines for appraising published systematic reviews/meta-analyses. Prerequisite: either introductory level courses in statistics, epidemiology, or biostatistics or permission of instructor. Offered: jointly with BIME 541/HSERV 529/PHARM 529.

EPI 542 Clinical Epidemiology (2) Weiss
Principles and methods involved in studying the outcome of illness. Prerequisite: EPI 511, or EPI 512 and EPI 513. Offered: S.
Instructor Course Description: Noel S Weiss

EPI 546 Psychiatric Epidemiology (3) Vander Stoep
Applies epidemiological methods to the study of mental illnesses. Topics include occurrence and distribution of mental illness, classification of psychiatric disorders; treatment-based vs. community-based studies; epidemiology of depression and schizophrenia; familial transmission; developmental epidemiology; mental illness and violence. Prerequisite: either EPI 511, EPI 512, HSERV 591, or permission of instructor. Credit/no-credit only. Offered: jointly with PBSCI 546; Sp.
Instructor Course Description: Ann Vander Stoep

EPI 547 Social Determinants of Population Health and Health Disparities (3)
Explores the elements and actions of a population health approach, including conceptualizing the determinants of health, synthesizing knowledge about major social determinants, and applying knowledge to improve population health and reduce health disparities. Enrollment priority for Health Services PhD students. Prerequisite: HSERV 511, permission of instructor; recommended: HSERV 512; HSERV 513. Offered: jointly with HSERV 514.

EPI 548 Social Determinants of Health: Research Methods (3) Beresford, Smith
Explores study design, measurement and analytic issues applicable to research into the social determinants of health and health disparities. Semi-weekly graduate-level seminar offered to students with a basic knowledge of epidemiological and biostatistical principles. Prerequisite: either EPI 511 or EPI 512/EPI 513; BIOST 511/BIOST 512 or BIOST 517/BIOST 518. Credit/no-credit only. Offered: jointly with HSERV 548; W.
Instructor Course Description: Nicholas L Smith

EPI 549 HIV/STI Prevention Research Methods (3) Baeten
Focuses on current research and implementation of HIV/STI prevention (biomedical, behavioral, and public health interventions). Includes analyzing strength of research evidence to support candidate interviews, understanding key features of clinical trial design, and applying appropriate/feasible interventions for specific settings and populations. Offered: jointly with G H 563; Sp.

EPI 554 Introduction to Epidemic Modeling for Infectious Diseases (3) Cassels
Covers the basic tools for building and analyzing mathematical models of infectious disease epidemics. Model types include deterministic and stochastic models, compartmental and individual-based models. Laboratory provides hands-on model building experience in Excel, Stella, and R. Offered: A.
Instructor Course Description: Susan L Cassels

EPI 555 Statistical Methods for Spatial Epidemiology (3)
Motivates the need for, and describes methods for the analysis of spatially indexed epidemiological data. Covers four major topics: clustering and cluster detection, disease mapping, spatial regression, and an introduction to geographical information systems. Considers both point-references and spatially aggregated data. Offered: jointly with BIOST 555; W.

EPI 570 Occupational and Environmental Epidemiology (3)
Research in occupational and environmental determinants of disease. Defining exposed populations, characterizing exposure levels, estimating disease risks relative to exposure. Cohort, case-control, cross-sectional designs for various health outcomes. Applications to exposure standard setting and risk assessment. Prerequisite: EPI 511 or EPI 512, EPI 513 or permission of instructor. Offered: jointly with ENV H 570; Sp.

EPI 571 Neuroepidemiology and Environmental Risk Factors (3) Kukull
Focus on neurologic diseases and etiology. Presentation of descriptive epidemiology, clinical features, and risk factors, including stroke, Parkinson's disease, Alzheimer's disease, multiple sclerosis, and other disorders. Discussion of NIH grantsmanship. Guest experts present some topics. Recommended: either EPI 511 or equivalent. Offered: jointly with ENV H 571; W, odd years.
Instructor Course Description: Walter A Kukull

EPI 573 Methods and Issues in Using Biological Measurements in Epidemiologic Research (3) Schwartz
Introduction to use of measurements from biological specimens in epidemiologic studies. Prepares epidemiology and laboratory science students for conduct of interdisciplinary human studies. Evaluation of biomarkers, preliminary studies, methodologic issues, quality control. Brief review of molecular biology. Applications and current literature discussed. Prerequisite: EPI 511 or EPI 512. Offered: jointly with ENV H 573; A.
Instructor Course Description: Stephen Marc Schwartz

EPI 582 Design and Analytic Strategies to Enhance the Validity of Epidemiologic Studies (1) Weiss
Discusses the issues that led to specific methodologic developments during the past 30 years, along with a characterization of these developments and the consequences of their application. Prerequisite: EPI 512; EPI 513. Credit/no-credit only. Offered: W.
Instructor Course Description: Noel S Weiss

EPI 583 Epidemiology Seminar (1, max. 12) Vander Stoep
Presentation of current epidemiologic research and application of epidemiologic research in the practice of public health. Offered: AWSp.
Instructor Course Description: Ann Vander Stoep

EPI 584 Doctoral Dissertation Seminar (1, max. 2) Davis, Holt
Forum for Epidemiology doctoral students to obtain information for doctoral research, including: project ideas; forming a committee; developing a proposal; conducting the project; and presenting results. Prerequisite: EPI 512 and EPI 513, admission to the PhD program, successful completion of the preliminary examination, or second-year status. Credit/no-credit only. Offered: AWSp.
Instructor Course Description: Victoria L. Holt

EPI 585 Injury and Violence: A Public Health Approach (3) Schiff
Focuses on broad concepts including a conceptual model, surveillance, research methods, control and prevention of injuries. Topics include unintentional injuries from motor vehicle crashes, falls, drowning, sports injuries and intentional injuries from youth violence, intimate partner violence, homicide and suicide. Recommended: EPI 511. Offered: A, even years.
Instructor Course Description: Melissa A Schiff

EPI 586 Responsible Conduct of International Research (3) Drake, Farquhar
Prepares international and U.S. students to develop research proposals, conduct international field research, and present scholarly work. Topics include proposal writing, human subjects protection, data management, peer review, scholarly integrity, responsible authorship, and grants and budget management. Open to graduate and non-matriculated students. Offered: jointly with G H 532; A.
Instructor Course Description: Carey Farquhar

EPI 587 Practical Aspects of Research Operations (2) Fitzpatrick
Provides the basics necessary to plan, implement, and manage a research study. Topics include human subjects applications, data collection, hiring and training of staff, participant recruitment and retention, data management, quality assurance and control, results reporting, communications, and budgeting. Prerequisite: K12 Clinical Scholar or one course in EPI/BIOST. Credit/no-credit only. Offered: A, even years.
Instructor Course Description: Annette L. Fitzpatrick

EPI 588 Preparing and Writing Research Proposals (2) Kristal, Reiber
Experience in preparing, organizing, and writing research proposals, following NIH and AHRQ guidelines. Includes weekly assignments and didactic exercises, leading to final research proposal. All students participate in mock study section to review and critique proposals. Prerequisite: second-year graduate student (PhD recommended), or PhD or MD in health-related field. Credit/no-credit only. Offered: Sp.

EPI 590 Selected Topics in Epidemiology or International Health (1-6, max. 6)
Tutorials arranged for a small number of students for in-depth examination of an area of epidemiology or international health, usually of current nature. Seminar format. Prerequisite: EPI 511. Also a special summer format presenting introductory material. May be offered with ENV H 590 and/or HSERV 590. For more information and permission, consult department program adviser. Offered: AWSpS.
Instructor Course Description: Stephen Marc Schwartz

EPI 591 Current Literature in Epidemiology (1, max. 15)
Articles pertaining to epidemiology and related subjects selected from the current literature to be distributed and read by all participants. Faculty members and enrolled students alternate being responsible for conducting sessions and choosing articles to read. Prerequisite: EPI 513. Credit/no-credit only. Offered: AWSp.
Instructor Course Description: Noel S Weiss Scott Davis

EPI 592 Program Seminars (1-6, max. 6)
Graduate seminars organized to address specific educational needs of students in various specialized programs within the Department of Epidemiology (i.e., Maternal and Child Health). Prerequisite: permission of instructor. Offered: AWSpS.

EPI 593 Cancer Prevention Research Laboratory (3, max. 24) White
Research experience for pre- and post-doctoral students working on cancer prevention projects at the Fred Hutchinson Cancer Research Center. Credit/no-credit only. Offered: AWSpS.

EPI 595 Epidemiology Master's Practicum (1-6, max. 6)
Supervised practice experience providing students an opportunity to learn how epidemiology is applied in a public health setting and in the formulation and application of public health policy. Prerequisite: EPI 512 and BIOST 511 or equivalent and permission of instructor. Credit/no-credit only. Offered: AWSpS.

EPI 600 Independent Study or Research (*-)
Prerequisite: permission of independent study supervisor. Credit/no-credit only. Offered: AWSpS.

EPI 700 Master's Thesis (*-)
Prerequisite: permission of thesis chair. Credit/no-credit only. Offered: AWSpS.

EPI 800 Doctoral Dissertation (*-)
Prerequisite: permission of dissertation chair. Credit/no-credit only. Offered: AWSpS.