How biological organisms produce materials with controlled structure, chemistry, and hierarchy to attain physical properties far superior to traditional engineering materials. Fundamental biological building materials, their synthesis, and their self-assembly with emphasis on examples of soft and hard tissues. Offered: W, even years.
The class will cover: Lesson from Mother Nature on molecular fabrication of organic and inorganic materials; Genetic selection of peptides and their post-selection engineering; Protein construction and synthesis; Bioinformatics; computational biology; molecular recognition: experimental and modeling; Utility of peptides as molecular erectors, synthesizers and assemblers; Applications in nanophotonics, magnetics, and electronics towards technology and medicine including engineered surfaces for implants, cancer diagnostics, stem cell molecular scaffolds, and tissue regeneration.
Student learning goals
1. Fundamentals of marriage of materials and genetics
2. Peptide structure and function
3. Molecular Biology of peptide design
4. Bioinformatics and computational biology towards in silico design of short peptides
5. Fundamental issues in nanotechnology
6. Utility of peptides as molecular erectors, synthesizers, and assemblers
General method of instruction
Seminar type one-to-one lectures by the instructor and invited instructors (experts in the field) on specific topics of the goals of the course; Discussions on topical themes; Literature search and reading of highlight papers; Preparation of term papers; preparation of project full proposals for NSF or NIH related to students' theses topics, plus others
Either of General chemistry, biochemistry, genetics, molecular biology, materials science and engineering, nanoscience/nanotechnology, any field of engineering, etc.
Class assignments and grading
HW, term paper, project proposals for NIH or NSF.
Class participation, assignments, and depth and breath of proposals.