If you modify your eGC1 after the PI or other reviewers have approved it, when you re-route it, the system will continue with the next approver. SAGE does not automatically start the approval process over from the beginning.
If significant changes are made that would modify the commitment of a unit, then the unit should be added to the approval flow using the Add Approver process.
If you change the PI, the organization receiving funding, or the answer to some compliance questions, the approval flow may change.