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School of Pharmacy

Mechanisms Underlying Individual Variation in Drug Response

The School of Pharmacy received this unit-specific UIF award as part of a recruitment package to attract a senior investigator with a track record in research and teaching in mechanisms underlying individual variations in drug response. Genetic polymorphisms in drug-metabolizing enzymes, drug transporters, and drug receptors are linked to interindividual differences in the efficacy and toxicity of many medications. Research in pharmacogenomics and functional proteomics provides the potential to elucidate the inherited nature of these differences in drug disposition and effects, thereby enhancing drug development and optimization of drug therapy based on each person's genetic constitution. Equally important will be establishing criteria for making decisions about which drugs and individuals (or groups of individuals) should be tested and monitored in this regard. As more and more drugs are used in an aging population, these decisions will become crucial both therapeutically and economically. Since the School of Pharmacy at the University of Washington is internationally recognized for its training and research programs in drug interactions and pharmacoeconomics, recruitment of a faculty member in any of the fields of functional genomics, proteomics or bioinformatics that has strong links to drug therapy will enhance our program quality and national competitiveness, and thereby aligns with a top strategic goal of the School of Pharmacy and the University of Washington.

Contact: Sidney Nelson
Dean, School of Pharmacy
Allocation: $25,552
Date Funded: December 1999