Merrill B Hille
Focuses on experimental design in cell biology. A topic of current research interest covered in depth in order to follow a line of investigation and critically evaluate the strengths and limitations of various experimental strategies. Offered: jointly with CONJ 536 .
Experimental Design in Cell Biology: Cell Migration
Focuses on experimental design in cell biology. The topic of current research interest is covered in depth this quarter is cell motility. We will follow this line of investigation and critically evaluate the strengths and limitations of various experimental strategies. Offered jointly as ZOOL 541 W or CONJ536.
The course goal is to gain experience in critically evaluating the strengths and limitations of experimental strategies and research tools used to study cell biology. This quarter the topic of current research interest we will cover in depth from several different perspectives is cell migration. We will evaluate key studies that led to our current understanding of the cellular mechanism and signaling that mediates cell migration. We will investigate techniques that can be applied to cells in cultures, in tissues, and in embryos. Class meetings will be a combination of lectures and discussion sessions in which all students will be expected to actively participate. Sessions will include treatment of historical developments that led to the formulation of major concepts and current controversies about unresolved issues.
The course assumes that students have the knowledge of general biochemistry, cell biology, and molecular biology equivalent to that covered in upper division undergraduate courses in these areas. The level for cell biology is comparable to that of "The Molecular Biology of the Cell" textbook by Alberts et al.
Class Assignments and Grading
Several primary research articles and/or reviews will be required reading for each lecture/discussion session. As an additional practical goal for graduate and professional training, students will learn to organize and present orally research results from the literature.
The final grade will be based on three components: a paper assigned at the end of the second week, your level of participation in the discussion sessions throughout the course, and the quality of your prepared oral presentations.