Cell biology and immunology explored through diseases of public health importance. Examples of pathogen interaction with host cell biology and immune systems, unique aspects of the cell biology of pathogens, perturbations of these systems in non-infectious diseases, and design of therapeutics and vaccines to combat diseases of public health importance. Prerequisite: undergraduate-level coursework in biology or molecular biology or permission of instructor. Offered: W.
The goal of this course is to expose graduate students to important concepts in cell biology as they relate to infectious disease and host-pathogen interactions. The emphasis will be on understanding the primary literature and learning how experiments in cell biology are designed, performed, and interpreted.
Students who are not in the Pathobiology graduate program should email email@example.com to confirm adequate preparation and to get permission to take the course.
Please note that because the University could not assign this class a larger room, enrollment in this course may be strictly limited to 14 students (we are working on ways to fit 2 more students into the room). If we are limited to 14, this leaves space for only 7 students who are not in the Pathobiology PhD program. Enrollment for non-Pathobiology students will be given out to PhD students in other programs in order of request.
Student learning goals
Understand principles of cell biology including the function of cellular organelles, RNA and protein trafficking, secretion, extracellular matrix, cell division, apoptosis, and signal transduction.
Understand how basic principles of cell biology apply to host pathogen interactions, using pathogen examples from the virology, bacteriology, and parasitology literature.
Understand how experiments in cell biology are designed, carried out, and interpreted.
Learn about new advances in the cell biology of pathogens and disease.
Do a short presentation on a paper from the primary literature that illustrates principles of cell biology of pathogens or disease.
Write a 5 page original, NIH-style grant proposal related to a topic covered in the course.
General method of instruction
Each class will consist of a 40 minute lecture on a topic related to the cell biology of host-pathogen interactions. Following the lecture there will be a 40 minute discussion of primary literature that was assigned in advance. Students are expected to participate actively in the discussion. Most of the class sessions will be conducted by Dr. Lingappa; 6 - 8 sessions will be conducted by guest lecturers.
Students should have had some exposure to molecular biology, immunology, and biochemistry.
Class assignments and grading
Primary literature articles and textbook chapters will be assigned for each class.
Grades are based on a 1 week take-home midterm exam (30%); a final NIH-style grant proposal (30%); one oral presentation (15%); written assignment for alternate oral presentation session (5%); participation in class discussions (10%); and written critiques of other students' NIH-style grant proposal (done using pseudonyms to preserve anonymity; 10%).