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Instructor Class Description

Time Schedule:

Norman S Wolf
PATH 450
Seattle Campus

Cell Biology of Aging

Pathophysiology of aging at cell and tissue levels (cell replication limits, telomere shortening, accrual of oxidative damage, caloric restriction effects, loss of postreplicative cells, longevity assurance genes). Proseminar based on student participation. Undergraduate Honors students, graduate students with biology, zoology, genetics, or medical sciences backgrounds. Prerequisite: permission of instructor. Offered: W.

Class description

This course will present the basic mechanisms of the aging phenomenon at the organismal, tissue, cellular and subcellular level, as currently understood. The theories concerning aging will be reviewed. Students should leave this course with an understanding of the field of basic science aging research. They will also have improved their information gathering and oral and written scientific presentation skills.

Student learning goals

General method of instruction

Class meetings are for 2.5 hours once each week of winter quarter. The proseminar format will be followed. Each session will begin with a presentation by a faculty member from within or without the Dept. of Pathology who has expertise in the subject matter for that week. This will be followed by 2 sequential student presentations. The student presenters will have chosen, read and prepared for presentation subject matter from an appropriate list of reprints pertaining to the subject for that week. Each student will present twice during the quarter and will turn in a short written summary of their presentation content. The course manager, Dr. Wolf will be present at all sessions and will guide the discussions of both the faculty and student presentations in which all enrolled students are expected to participate. An excellent text is assigned and will be purchased at the U. Bookstore, Medical Branch, South Campus: Biology of Aging (R. Arking, 2nd ed.). Weekly text reading assignments will be given to the class.

Recommended preparation

This course is open only to Biology Honors Program undergraduate students (occasional graduate students in related programs may be allowed entry). An enrollment maximum of 10 is designed to allow the greatest participation and personal attention. Students should have some course background in biology at the cellular level, biochemistry and at least minimal acquaintance with genetics. Past experience in class papers and/or term papers will be helpful.

Class assignments and grading

Text readings for all students each week. Indivdual assignments for class presentation and written summary (each student 2X during the quarter). Term paper on subject chosen by the student and approved by instructor.

Individual's class presentations and written summations of the papers read and presented:40% Class participation: 10% Term paper: 50%


The information above is intended to be helpful in choosing courses. Because the instructor may further develop his/her plans for this course, its characteristics are subject to change without notice. In most cases, the official course syllabus will be distributed on the first day of class.
Last Update by Norman S Wolf
Date: 08/20/1999