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Instructor Class Description

Time Schedule:

Edward A Clark
IMMUN 535
Seattle Campus

Host Defense to Infection

Addresses the mechanisms protecting against pathogens that infect patients with cancers; immune regulation; new developments in vaccines. Companion course with IMMUN 533. Prerequisite: graduate standing in Immunology; other graduate students with permission of instructor. Offered: Sp, even years, weeks 1-5.

Class description

"Host Defense to Infection" is offered during the first 5 weeks of Spring Quarter during EVEN numbered years only -- 2010, 2012, etc. A two-part course, 535 is offered on alternate years with Immun 533 "Host Defense to Cancer", which is offered in ODD numbered years only -- 2011, 2013, etc. Course chair for both is Dr. Edward A. Clark. This course addresses the mechanisms leading to protective immunity to infectious agents observed in compromised hosts such as patients with cancers and/or HIV. It also addresses immune regulation and start-of-the-art approaches for vaccines.

Student learning goals

Understand current view of protective immunity to pathogens.

Understand the relative roles of dendritic cells, NK cells, T cell subsets and neutralizing antibodies in protective immunity.

Understand role of interferons/cytokines in protective immunity to viruses/bacteria.

Understand current views and strategies for vaccine development.

Expose students to primary literature in area of host immunity to pathogens.

At the end of the course students will have read and presented papers in the area of host immunity and developed an integrated view of protective immunity. Students will know how to find, read, digest and discuss current literature and concepts in the field.

General method of instruction

Recommended preparation

Open only to graduate students in the IMMUNOLOGY PH.D. program. Other graduate students (i.e. MCB) may contact the course chair for permission to enroll. Please be prepared to provide your transcripts and current course of study/research.

Class assignments and grading

Readings: For each lecture and discussion session, students will be assigned a set of primary literature including a current comprehensive review and some key research articles to be discussed in depth.

Presentations: For each class 2 or 3 students will be assigned to prepare an overview and summary of current thinking in the field and presentations of the primary literature. The students will be in charge of leading a discussion of the papers and summarizing the findings and future prospects for research in the area at the end of the discussion.

80% grade based on either a problem set (answers to 3 of 5 questions, one from each lecture) or a 10-page paper, and 20% on class participation and presentations. Two to three students will be assigned as discussants of paper each week.


The information above is intended to be helpful in choosing courses. Because the instructor may further develop his/her plans for this course, its characteristics are subject to change without notice. In most cases, the official course syllabus will be distributed on the first day of class.
Additional Information
Last Update by Peggy A. Mccune
Date: 01/19/2010