John A Stamatoyannopoulos
A detailed examination of the mechanisms of transcription and translation as determined by experimental genetics, molecular biology, and biochemistry.
This course covers the fundamentals of gene regulation, with the major emphasis on regulation of transcription in eukaryotes.
Student learning goals
Fundamentals of transcriptional regulation
Students should emerge with sound knowledge of seminal literature
General method of instruction
- Focus on primary scientific literature; no course textbook - Interactive / Socratic discussion
Prior knowledge of transcriptional mechanisms is not required. A basic understanding of gene structure is desired.
Class assignments and grading
-Assignments consist of critical evaluation of seminal articles from the scientific literature. - Specific questions are handed out in advance and students are expected to prepare them for the subsequent class. - Beginning second week of class, weekly brief written tutorials
- Grading based on class participation and tutorials