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Instructor Class Description

Time Schedule:

Christophe Verlinde
CONJ 545
Seattle Campus

Molecular Interactions and Medicine

Forces governing molecular interactions in biology; with a focus on medicine. Principles of computer modeling techniques in use for predicting the molecular behavior of proteins, ligands, and their complexes. In computro ligand discovery; drug design, and the understanding at the atomic level of some genetic diseases. Two computer lab sessions. Offered: Sp.

Class description


This course aims to provide a basic understanding of the various forces governing molecular interactions in biology, with a focus on medicine. In addition, students will be introduced to the principles of computer modeling techniques that are in use for predicting the molecular behaviour of proteins, ligands and their complexes. The power of these techniques will then be illustrated in terms of in computro ligand discovery, drug design, and the understanding at the atomic level of some genetic diseases. Practical experience will be gained during one computer lab session.

Note that this is NOT a training course in using a particular molecular software package.

Sessions ===== 1.Forces and Energies 2.HBonds and Salt Bridges 3.Electrostatics 4.Molecular simulations 5.Solvation 6.Membrane protein folding and stability 7.Molecular modeling session: ligand docking

Student learning goals

General method of instruction

Lectures, assignments, and computer lab.

Recommended preparation

The course will assume knowledge at the level of an advanced undergraduate level of biochemistry, math and physics. Be aware that principles of physical chemistry and equations will not be eschewed. (I assume you know calculus and Pythagoras' theorem, enthalpy, entropy, free energy)

Recommended reading (Not mandatory) Andrew R. Leach. "Molecular Modelling: Principles and Applications". Prentice Hall, 2nd edition, 2001.

Class assignments and grading

Studying papers and presenting them.

Grading Students will be graded on in-class participation and a final written exam. Participation includes in-class assignments and the demonstration of familiarity with assigned reading during in-class discussions.

Grade history: median 3.5

The information above is intended to be helpful in choosing courses. Because the instructor may further develop his/her plans for this course, its characteristics are subject to change without notice. In most cases, the official course syllabus will be distributed on the first day of class.
Last Update by Christophe Verlinde
Date: 04/22/2013