Seminar focusing on molecular pathways that maintain genomic stability in all cells and that carry out programmed changes in genomic structure in the immune system. Special attention devoted to understanding how failure in these pathways leads to genomic instability and malignancy. Prerequisite: permission of instructor.
Genomic instability is a key event in cancer and aging,and highly conserved pathways have evolved to maintain genomic stability by repairing damaged DNA. This course will explore very recent advances in understanding the nature and causes of genomic instability, the mechanisms of normal DNA repair, and the consequences of failure in DNA repair to human health and disease.
Please note that this course has been rescheduled to second half of Fall quarter, 2004; and will not be given in Winter, 2005. This differs from the listing in the Catalog, which is printed every other year.
Student learning goals
General method of instruction
The emphasis throughout the course will be on current research literature and recent advances in this very active area of human disease research.
Class assignments and grading
Each student will write a short (7-10 page) paper on a specific gene chose in the first week of the quarter. The paper will serve as the basis for a short oral presentation in class during Week 5. The goals of the paper will be to 1. identify one important, unanswered question regarding gene function, and 2. to present one or several experiments that answer that question.
Presentation and talk