Charles W Frevert
C MED 592
Introduces the interpretation of pathological changes in animals used for biomedical research, with a focus on the mouse. Covers study design and interpretation, techniques to measure pathological changes in major organ systems plus other topical material related to preclinical drug studies and translational research.
CMED 592 provides students with an introduction to comparative pathology and physiology as applied to to preclinical drug studies and translational research. Classes will cover anatomy, physiology, pathophysiology and techniques to measure pathological changes in major organ systems. In addition, students will receive a background in study design, the definition of adverse outcomes in drug studies, the use of genomics, proteomics, and metabolomics in animal studies.
Student learning goals
Have a basic understanding of study design, statistical analysis, and the differences between adverse and nonadverse outcomes in animal studies.
Know what samples to take and the proper techniques for sample collection during the course of a study and at necropsy.
Have a basic understanding of how clinical chemistries, complete blood counts, cytology, and urinalysis are used to measure organ function and injury.
Have a basic understanding on the use of genomics, proteomics, and metabolomics in animal studies. This includes understanding the limitations of Omics, the considerations for study design when using Omics, and the appropriate ways to analyze data collected from animals studies.
Be able to design a study to investigate a new drugs or basic mechanisms of disease using animal models.
Understand the limitations of animal models as a tool to study human disease.
General method of instruction
Because of the nature of this course the lectures will be a combination of problem based learning and seminars on specific topics. Examples of lectures that will be in a seminar format includes seminars such as "Toxicogenomics for Hazard Identification and Mechanistic Inference".
It is expected that students will have a basic understanding of anatomy and physiology prior to taking this class.
Class assignments and grading
There will be four take home problem sets.
Students will be graded on the following: 1) Participation in class, 2) Four take home problem sets, and 3) Final Exam – Take home problem set.
Grade Weighting 1. Class Participation: 25% 2. Take home problem sets: 50% 3. Take home final exam: 25%