Physiological systems, emphasizing cardiovascular, pulmonary and to a lesser extent, renal, hepatic, and endocrine systems, described in quantitative terms, using model representation for examples and problems. Laboratories. Prerequisite: BIOEN 588, calculus and ordinary differential equations.
The cell, the organ and the organism are complex systems, best understood by defining quantitative relationships between components. The physiology is based on the anatomy and on the integrated relationships among the elements of the system. The learning consists therefore of both the factual information found in the standard texts and in the approach to constructing one's ideas about how the system works, quantitatively if at all possible.
Student learning goals
General method of instruction
Lecture/discussions on describing the physiology in physical and biological terms and then figuring out, only for parts of the systems, how to integrate the information so as to approximate the structural and functional behavior of the system using algebraic and differential equations.
Prior study in cell biology and general physiology of the cell. Review of medical physiology texts. Refresh knowledge of differential equation solving. Practice applying physical and chemical insight into explaining observed physiological behavior. Some reminders of biochemical systems.
Class assignments and grading
The lectures will combine reviews of elementary processes involved in cardiovascular and respiratory physiology particularly, with illustrations of applications at the research forefront from current literature. The labs will be problem solving using mainly modeling and analysis of physiological systems. Homework problems: about three sets during the quarter. Group program to build and present a CV-Resp model with realistic functionality.
Homework 20%; labs 20%; group project and its presentations, 20%; midterm,20%; final 20%