Basic cell and molecular biology of the pathologies associated with biomaterial implantation that limit bioprosthetic use, including hemostasis, infection, acute and chronic inflammation, wound healing and fibrosis, and structural alterations. Major methods for histological analysis of retrieved implants. Prerequisite: general biology, BIOEN 490 (may be taken concurrently), or permission of instructor.
1. Students will gain in-depth knowledge and understanding of basic molecular, cellular, and physiological host processes related to biomaterial implantation. 2. Students will independently research and analyze the current literature related to implant biocompatibility of a specific medical device and prepare a written report(midterm) and a mock NIH proposal (final exam). 3. Students will gain familiarity with techniques used for histochemical examination of retrieved implants.
Student learning goals
General method of instruction
Instruction will include didactic lectures, student presentation of current topic papers, and class discussion.
Prereq: BIOEN 490, BIOEN 450, BIOEN 451, or permission of instructor.
Class assignments and grading
critiques and presentation of current topic paper, midterm research paper, and final grant proposal.
25% critiques of current topic papers 25% current topic paper presentation 25% midterm research paper 25% final grant proposal