UW Research

Alzheimer’s Disease Patient Registry



The University of Washington Alzheimer Disease Patient Registry (ADPR) is a model clinical and epidemiological database for dementia and Alzheimer’s disease (AD). It was established in late 1986 by a grant from the National Institute on Aging and is based in a large health maintenance organization-Group Health Cooperative of Puget Sound (GHC), now Kaiser Permanente Washington (KPWA). The ADPR enrolled only cases of dementia and AD who came to medical attention since January 1987. Enrollment was completed in March 1996. Epidemiological/genetic studies based on ADPR are ongoing.

The formation of the Adult Changes in Thought (ACT) sample is also based at KPWA and consists of a cohort of cognitively intact (at enrollment) research subjects age 65 or older. This portion of the study follows subjects forward in time and compares the occurrence of dementias (primarily AD and vascular dementia) and risk factors between the previous case-control analyses, as well as with ongoing cross-cultural studies. Study enrollment has taken place in three different waves: the original cohort (enrolled 1994-1996) enrolling 2581 subjects; the Expansion cohort (enrolled 2000-2003) enrolling 811 subjects; and the ongoing Replacement (continuous) enrollment cohort (2004 to present). To date more than 5700 participants have been enrolled.

The University of Washington and KPWA have worked in close collaboration since the inception of the ADPR and ACT studies.

Funding Information

National Institute on Aging

Related UW Entities

School of Medicine: Department of Laboratory Medicine