UW Research

Existing Reliance Agreements

UW has entered into several standing reliance agreements. These pre-negotiated agreements establish the terms of reliance and a common understanding of the roles and responsibilities of reviewing and relying institutions.

Master reliance agreements
These agreements do not specify certain types of studies or name a particular IRB that will serve as the reviewing IRB. The use of these agreements is optional and the reviewing IRB must be identified and confirmed as acceptable by all involved institutions on a study-by-study basis.

SMART IRB Master Reliance Agreement

The SMART IRB Agreement facilitates reliance arrangements among participating organizations. Use of the agreement is required for participation in studies reviewed by Trial Innovation Network Central IRBs.

 

Central IRB Agreements
Central IRB (CIRB) Agreements do name a particular IRB that will serve as the reviewing IRB for all studies under the agreement. They are typically used for studies that are part of a network or consortium.

Advarra

The UW will rely on Advarra to serve as the IRB for industry-sponsored-and-initiated studies and other research as determined on a case-by-case basis by HSD staff.

Jaeb Center for Health Research (JCHR)

The UW may rely on the Jaeb Center IRB to serve as the IRB for studies conducted in collaboration with JCHR. Studies are evaluated for Jaeb reliance on a case-by-case basis by HSD staff.

Prevention and Treatment of Acute Lung Injury (PETAL) Network CIRB

The UW will rely on the Vanderbilt IRB to serve as the IRB for all PETAL Network studies.

NIH StrokeNet CIRB

The UW will rely on the University of Cincinnati IRB to serve as the IRB for all StrokeNet studies.

Cancer Consortium IRB (CC-IRB) operated by FHCRC IRB

The UW must rely on the CC-IRB operated by FHCRC IRB for investigator-initiated, cancer-related, more-than-minimal-risk research that is conducted by UW faculty who are members of the Cancer Consortium.

WIRB

The UW relies on WIRB to serve as the IRB for industry-sponsored-and-initiated studies and other research as determined on a case-by-case basis by HSD staff.

National Cancer Institute (NCI) Central IRB

The UW will rely on the NCI CIRB for studies that are required to obtain review from the NCI CIRB. This reliance is negotiated on behalf of UW by Seattle Children’s for pediatric research. See the NCI CIRB study authorization process on this page.

National Marrow Donor Program (NMDP) Central IRB

The UW will rely on the NMDP CIRB for BMT and CIBMTR studies that are required to obtain review from the NMDP CIRB.

Northeast ALS (NEALS) Central IRB

The UW will rely on the Partners IRB to serve as the IRB for all NEALS Consortium studies.

 

Cooperative Agreements
Cooperative agreements are typically established between institutions who frequently collaborate on research studies. The agreements specify which IRB will do the review for both institutions, under which circumstances. These agreements do specify which IRB will serve as the reviewing IRB.

Seattle Children’s

The cooperative agreement terms are outlined on this page.

Fred Hutchinson Cancer Research Center (for studies that are not part of the Cancer Consortium)

Contact HSD for the terms of this agreement

Kaiser Permanente of Washington (formerly Group Health)

The cooperative agreement terms are outlined on this page.

Public Health - Seattle and King County

Contact HSD for the terms of this agreement

Benaroya Research Institute at Virginia Mason

The cooperative agreement terms are outlined on this page.

Washington State IRB at DSHS

Contact HSD for the terms of this agreement.

VA Puget Sound Healthcare System

Due to national VA policy, the Puget Sound VA (VAPSHCS) does not have a cooperative agreement with the UW IRB> Therefore, any UW research that involves the VA in certain ways (as described in the SOP Engagement) will require review by both the UW IRB and the VAPSHCS IRB.