Why am I asked to provide rationale for using hESC lines?

One charge of ESCRO is to gain public trust. The application asks for rationale so that PIs provide information to address potential public concern. The information below should be included in your response:

  • Explain why other approaches have weaknesses and how your proposed method avoids or mitigates against these problems. For example, one response might be that hESCs are much less likely to be mutated.
  • Describe the advantages/disadvantages of using hESC for this project compared to other types of cells, for example, adult stem cells.
  • Cite and describe supporting data and research in peer-reviewed scientific journals. If there are valid alternatives to using hESC to answer research questions, please briefly describe why these alternatives are not being used.