Research Activities

Our faculty carry out research within the Center for Immunity and Immunotherapies (CII) at Seattle Childrenís Research Institute. Our Center, also directed by Dr. Rawlings, brings together a dynamic group of distinguished experts across multiple disciplines to solve some of the immune systemís most complex problems. CII researchers treat patients in the Immunology, Rheumatology and other clinics at Seattle Childrenís Hospital with the ultimate goal of applying what is learned in research to progressively advance the care of our patients.

Research within the CII extends full-circle, rapidly evolving from clinical questions to laboratory-based investigation and back to patients in the form of improved diagnostic tools for primary immune deficiency and autoimmune diseases, advanced therapies for genetic disorders, innovative vaccine strategies and enhanced immune monitoring techniques.

Harnessing the Immune Systemís Healing Potential

We begin with the premise that a childís immune system has vast healing potential. We focus on harnessing that potential by manipulating the immune system to treat pediatric diseases, including immune deficiency, autoimmunity, allergies, organ transplant rejection, infections and cancer. As part of this work, we are improving the molecular definition and diagnosis of immunological disorders, developing disease-specific cell therapies and stem cell transplantation approaches, modulating immune function through small-molecule therapeutics and working to cure immune deficiencies through cutting-edge gene therapy and gene repair.
Gene Therapy on CII
Northwest Genome Engineering Consortium (NGEC)

Working Collaboratively to Achieve Improved Health and Better Outcomes

Because the challenges are exceedingly complex, we search broadly for answers. For example, we leverage the strengths of our investigators and the broad expertise of our collaborators within the Northwest Genome Engineering Consortium (NGEC) in Seattle, along with other prominent academic and biotech research groups here and around the world. We are actively recruiting researchers who are leaders in the field — as well as graduate students, postdoctoral researchers from within, and beyond, the University of Washington Department of Immunology and technicians with outstanding scientific talent — to join our thriving research community and complement our existing expertise by bringing new approaches, innovations and capabilities.

Above all, we are motivated by our patientsí courage and are committed to helping them achieve improved health and better outcomes.

To take a tour of the Center for Immunity and Immunotherapy programs, please visit our website at:

For more information on this specialty, please visit the Immunology webpage.