Research

HMC Department of Surgery

The University of Washington is one of the largest, best supported, and most productive research universities. Our residents and fellows have access to a broad spectrum of outstanding research.

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PubMed

HMC Ongoing Research

Harborview Research Personnel

NAME	CONTACT	TITLE
Hikmatullah Arif	arifh@uw.edu	Research Study Coordinator, Trauma
Austin Bailey	bailea4@uw.edu	Research Assistant, Burn
Claudia Baker	clabake@uw.edu	Research Assistant, Burn
Elizabeth Barnes	barneeli@uw.edu	Research Assistant, Trauma
Gretchen Carrougher RN, MN	carrough@uw.edu	NIDILRR Research Nurse Supervisor
Emily Eschelbach, RN	eschee13@uw.edu	Research Nurse, Burn
Iris Garcia	igarc@uw.edu	Manager of Program Operations, Research
Wendy Hamar	wh12@uw.edu	Research Coordinator, Vascular
Laura Hennessy, RN	hennessy@uw.edu	Research Nurse Supervisor, Trauma
Mahrukh Kadri	mahrukhk@uw.edu	Research Assistant, Trauma
Brenda Allen-Kline, RN	brenda99@uw.edu	Research Nurse, Vascular
Patricia Klotz, RN	pklotz@uw.edu	Research Nurse Supervisor, Trauma
Stephen Sibbett	ssibbett@uw.edu	Research Technoloist, Gibran Lab
Keegan Stromberg	keeg7342@uw.edu	Research Assistant, Trauma

Clinical Trials

Research projects are organized by PI and their respective Section Membership. HIPRC Faculty may belong to multiple Sections.

PI	Department	Project
Saman Arbabi	Surgery	A Prospective Randomized Prehospital Double-blind, Placebo Controlled Pilot Trial Comparing Kcentra plus Standard of Care to Placebo plus Standard of Care in Trauma Patients with Hemorrhagic Shock This study evaluates the feasibility of the EMS to identify patients in shock and the ability to package, store and administer Kcentra in the field. It also evaluates the safety and efficacy of Kcentra, a four factor prothrombin complex, as an alternative to plasma transfusion.
Eileen Bulger	Surgery	Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Study of AB103 as Compared to Placebo in Patients with Necrotizing Soft Tissue Infections This a pivotal Phase 3 clinical trial that investigates the efficacy and safety of AB103, an investigational drug, for the treatment of NSTI.
Eileen Bulger	Surgery	Physiologic signals and signatures with the Accuryn Monitoring System in Intensive Care Patients This is an observational study of physiologic signals using the Accuryn urinary drainage monitoring system.
Nicole Gibran	Surgery	A Multicenter, Multinational, randomized, controlled, assessor blinded study, performed subjects with thermal burns, to evaluate the efficacy and safety of NexoBriod compared to Gel Vehicle and compared to Standard of Care This is a Phase 3 clinical trial to evaluate the efficacy and safety of enzymatic eschar removal with NexoBrid as compared to Gel Vehicle and standard of care.
Samuel Mandell	Surgery	The RE-ENERGIZE Study: A Randomized Trial of Enteral Glutamine to Minimize Thermal Injury This double-blinded clinical trial looks to examine what is the effect of patient specific dosages of enteral glutamine, a protein supplement, on 6 month mortality in severely burned patients.
Tam Pham	Surgery	Protective Effects of Propranolol in the Severely Burn Patient: A Safety and Efficacy Trial This prospective multicenter randomized efficacy and safety trial examines the physiologic effects and safety of propranolol administered to adult patients with severe burn injury. In addition, this study looks to identify which subpopulations may be most likely to benefit from propranolol treatment, and to identify safe and effective propranolol dosing levels.
Tam Pham	Surgery	Burn Navigator: Evaluation of the Effectiveness of the Burn Navigator in Improving Resuscitation Outcomes This proposal will test the ability of a new FDA-cleared computerized burn resuscitation system (Burn Navigator) to improve burn resuscitation and monitoring.
Tam Pham	Surgery	Peds Nexobrid: A multicenter, multinational, randomized, controlled, open label study, performed in children with thermal burns, to evaluate the efficacy and safety of NexoBrid as compared to standard of care (SOC) treatment This study is a multi-center trial to evaluate the efficacy and safety of Nexobrid, a non-surgical eschar removal treatment over Standard of Care (SOC) treatment of thermal burns in children.
Tam Pham	Surgery	Avita RECELL: A Prospective Multicenter Randomized Controlled Clinical Study to Investigate the Safety and Effectiveness of RES (Regenerative Epidermal Suspension) Prepared with the RECELL® Device Compared to Conventional Care for Healing of Donor Sites in Infants, Children and Adolescents (Aged 1–16 Years) This is a trial to investigate whether autologous skin cell suspension prepared with the RECELL device (i.e., RES) can be safely and effectively used to promote healing of study donor sites created for sourcing tissue during treatment of skin defects requiring autografting.
Bryce Robinson	Surgery	Phase 3 Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Safety and Efficacy of Reltecimod as Compared to Placebo in Addition to Standard of Care in Patients with Sepsis-associated Acute Kidney Injury This is a Phase 3 clinical trial to evaluate the safety and efficacy of Reltecimod, a CD28 antagonist, in attenuating the inflammatory response in patients with sepsis-associated acute kidney injury.

Research Studies

PI	Department	Project
Eileen Bulger	Surgery	Therapeutic Limb Cooling to Prevent Amputation in Prolonged Damage control Resuscitation
Eileen Bulger	Surgery	Development of a National Trauma Research Action Plan
Joseph Cuschieri	Surgery	A comparison of Google Glass and traditional video vantage points for bedside procedural skill assessment
Joseph Cuschieri	Orthopaedics	Prevention of Clots in Orthopaedic Trauma (PREVENT CLOT): A Randomized Pragmatic Trial comparing the complications and Safety of Blood Clot Prevention Medicines Used in Orthopaedic Trauma Patients (Co-PI)
Nicole Gibran	Surgery	Surgical Wound Repair: fibroproliferative responses to cutaneous injury
Ronald Maier	Surgery	Improving Outcome in Ischemia and Ischemia Reperfusion Injury Using Elemental Reducing Agents
Charles Mock	Surgery	Injury Prevention in Ghana
Grant O’Keefe	Surgery	Protein-enhanced enteral nutrition and metabolomics in critically ill trauma and surgical patients
Grant O’Keefe	Orthopaedics	A multi-center, prospective observational study to evaluate the use of Patient-Specific Precision Injury Signatures to Optimize Orthopaedic Interventions in Multiply Injured Patients (PRECISE STUDY) (Co-PI)