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Instructor Class Description

Time Schedule:

Ian N. Crispe
PATH 512
Seattle Campus

Molecular Basis of Disease: Death and Repair

First in a series designed to introduce students to medically important diseases and physiologic processes and experimental approaches to elucidating the cellular processes underlying these diseases. Covers basic cell/tissue processes that underlie normal homeostasis and most disease and, including apoptosis, necrosis, stem cells, inflammation, granulation tissue, tissue regeneration, repair and fibrosis.

Class description

The course provides an introduction to mechanisms of tissue injury and repair, and their analysis through microscopy and flow cytometry. Different organ systems are used to illustrate the principles of diagnostic and experimental pathology.

Student learning goals

Understand fundamental process of cell injury and repair, and know how that are visualized.

Both understand, and have toured advanced microscopy and flow cytometry facilities

Know how the basic approaches of tissue analysis are used in both clinical and research settings.

Have seen these principles in action in the context of diverse disease disease groups, including diseases of the skin, prostate, kidney and cardiovascular system.

General method of instruction

This course will be taught by lectures and demonstrations.

Recommended preparation

This is an introductory course. There are no specific prerequsities.

Class assignments and grading

The class will be graded using a final exam.

Questions will emphasize knowledge of the basic material presented in the preceding sessions.


The information above is intended to be helpful in choosing courses. Because the instructor may further develop his/her plans for this course, its characteristics are subject to change without notice. In most cases, the official course syllabus will be distributed on the first day of class.
Last Update by Ian N. Crispe
Date: 09/11/2013