Time Schedule:
William N Howald
MEDCH 530
Seattle Campus
Current approaches to the combination of liquid chromatography with mass spectrometry for small molecules. Mass spectrometry of drugs, toxicants, metabolites. Emphasis on interpretation skills, with problem sets each week. Introduction to LC/MS instrumentation. Ionization methods appropriate for small molecules. Capillary LC/MS and capillary electrophoresis. Offered: even years; Sp.
Class description
After taking this course you should have developed a basic understanding of the main types of techniques and instruments used in mass spectrometry and associated chromatographic methods of sample introduction, as well as a basic familiarity with the interpretation of their data. The course will focus on the applicability, information content, advantages and limitations of each technique.
Student learning goals
General method of instruction
This course is team-taught, involving both UW faculty and invited speakers from academia, industry and government laboratories. William (Bill) Howald, Rm I-093 HSB (howald@u.washington.edu), and Thomas (Tom) Kalhorn, Rm I-093 HSB (tfk@u.washington.edu), are the course instructors and coordinators.
Recommended preparation
Class assignments and grading
Every lecture will have a reading assignment and you are responsible to do the readings BEFORE each class. A few times throughout the quarter we will have a written question about the reading at the beginning of the lecture. We may also ask you questions about the reading during the lecture. In addition, all participants in the class are required to submit a written question at the end of each week on material covered during over the period.
The grade will be determined as the weighed average of: · 30% take-home exam due at class on Monday, April 28th · 30% take-home exam due at class on June 2nd · 20% homework · 20% class participation (including written questions on reading and questions submitted weekly by the students) · There will be no final examination.
