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Instructor Class Description

Time Schedule:

Zhengui Xia
ENV H 567
Seattle Campus

Mechanisms of Carcinogenesis

Lectures/presentations of biochemical and molecular basis of carcinogenesis induced by environmental agents, including approaches to identification of carcinogens. Role of cell proliferation and cell death (apoptosis) in cancer formation and cancer treatment. Molecular mechanisms that regulate proliferation and apoptosis. Prerequisite: ENV H 516, ENV H 405, or permission of instructor. Offered: jointly with PHCOL 567; A, even years.

Class description

This is an introductory course for graduate students who are interested in the biochemical and molecular basis of carcinogenesis. Guest lectures will be given by faculty from the University Health Sciences and Fred Hutchinson Cancer Center who are experts in various fields of cancer biology.

Topics include: Cell Cycle Regulation and Cancer; Proto-Oncogenes, Oncogenes, And Tumor Suppressor Genes; Transgenic models in cancer research; Chemical carcinogenesis; Mutagenesis and DNA repair; Apoptosis In Cancer; Cell-cell communication and human cancer; Gene therapy and cancer drug discovery strategies.

Student learning goals

General method of instruction

This class will provide a broad overview of molecular mechanisms of carcinogenesis. The class format will include critical review of the original literature, small group discussions, and oral presentations by students and faculty.

Recommended preparation

Class assignments and grading


The information above is intended to be helpful in choosing courses. Because the instructor may further develop his/her plans for this course, its characteristics are subject to change without notice. In most cases, the official course syllabus will be distributed on the first day of class.
Last Update by Shannon L. Kirkpatrick
Date: 08/30/2004