Evan P Gallagher
ENV H 533
Advanced discussion of molecular mechanisms whereby chemical and biological agents produce their harmful effects on biological tissues. Topics include the role of xenobiotic biotransformation enzyme expression in chemical susceptibility, toxicogenomics, chemical-induced oxidative stress, alternative models, species differences, and dietary anti-carcinogens. Prerequisite: prior coursework in toxicology and biochemistry, or permission of instructor. Offered: Sp, odd years.
1. To examine current and original toxicological research relating to the molecular and biochemical mechanisms of chemicals and other toxicants with cell systems.
2. To provide opportunities for the students to increase their abilities to critically review the current molecular toxicology research and to help develop oral presentation skills.
Student learning goals
General method of instruction
Class will meet once per week for approximately two hours (tuesday, 11:30-1:20, room TBA). Readings will be assigned for each week's class and will be distributed at least one week prior to their discussion. The first class will be an overview of the field of molecular toxicology by the instructor.
Each subsequent class will consist of three 20-30 minute sections. In the first section, the instructor will present a ~20 minute overview on the subject area for the current class. The overview will provide a basis for subsequent discussions and will be followed by two student-led presentations. These presentations will entail 30 minute presentations. The first consisting of a short introduction to the area and a critical presentation of one or two previously-assigned research article(s). The student should provide a handout related to their presentation. Each presentation will include or be followed by ~15-20 minutes of further class discussion on the respective subject area.
Class assignments and grading
Distributed readings are to be read before class.
2. Each student will lead at least one class presentation, consisting of the topic review and presentation of the scientific paper. The presentation will account for 35% of the quarter's grade and will be evaluated based on clarity, organization, and quality of discussion items raised. Each presentation will be evaluated by the students and instructor.
3. Everyone is strongly encouraged to participate in class discussions. Class participation will be counted as 15% of the quarter’s grade. 4. Two, one-page manuscript reviews accounting for the remaining 50% (i.e. 25% each) of the grade will be collected during the quarter. The reviews will be conducted on a draft manuscript handed out by the instructor. Criteria for the evaluation of manuscripts will be provided by the instructor. The review should critically appraise the selected paper and then with a final decision as to whether you would accept, accept with major revisions, except with minor revisions, or reject the paper for publication.