Elaine M. Faustman
ENV H 532
Investigates chemicals that can induce adverse reproductive and developmental outcomes. Discussion topics include identification and characterization of specific classes of toxic agents, mechanisms of action of these agents at the molecular and cellular level, and risk assessment and regulatory issues. Prerequisite: ENV H 514 and ENV H 515 or ENV H 405 or permission of instructor. Offered: S; even years.
This class will cover basic principles of normal reproduction and development and then focus on how and when environmental chemicals induce adverse reproductive and developmental outcomes. Discussion topics include identification and characterization of specific classes of reproductive and developmental toxicants, mechanisms of action of these agents at the molecular and cellular level, and risk assessment and regulatory issues relevant for reproductive health.
Student learning goals
Describe the main themes of reproductive and developmental toxicology and Identify new emerging issues for reproductive public health.
Discuss current research issues in these topics.
Summarize in-class laboratory demonstrations assessing reproductive and developmental toxicology. Characterize strengths and limitations in applying these approaches for assessing reproductive and developmental impacts.
Apply approaches for data integration for evaluating these complex and dynamic endpoints.
Demonstrate skills for synthesis and oral and written reporting of research.
Share in the excitement of this area of study.
General method of instruction
The course will include discussions of recent literature as well as in-class demonstrations of laboratory-based assessments for reproductive and developmental toxicology. A key focus will be on understanding gene-environment issues. Practical approaches for communicating developmental and reproductive risk issues will be given. As a base for this course we will use a free Primer from the Teratology Society, an electronic copy of which will be made available to all students. Offered in the Summer (of even years) it provides an in depth immersion for these important endpoints in public health.
Prerequisite: ENV H 514 and ENV H 515 or ENV H 405 or permission of instructor.
Class assignments and grading
Students are required to constructively participate in class discussions and to synthesize scientific literature and key issues into discussions, presentations, and written materials (short manuscripts reviews, and required paper). Students who miss a session will be responsible for preparing the overheads and key points and sending these to the instructor prior to class.