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Instructor Class Description

Time Schedule:

Zhengui Xia
ENV H 514
Seattle Campus

Fundamentals of Toxicology

Covers major fundamentals and core areas of toxicology, including dose response, absorption, distribution, metabolism, and excretion of toxicants, toxicity testing, interpretation of toxicological data; and biochemical, cellular, and physiological mechanisms by which chemicals produce toxic responses. Also explores mechanisms and fate of chemical interaction with biological systems. Prerequisite: BIOL 212, BIOC 405, or permission of instructor. Offered: A.

Class description

The goal of this course is to introduce students to fundamental concepts of toxicology, including dose response, absorption, distribution, metabolism, and excretion of toxicants, toxicity testing, interpretation of toxicological data, biochemical, cellular, and physiological mechanisms by which chemicals produce toxic responses. Students will also gain appreciation on basic aspects of biotech and regulatory toxicology.

The new title of the course from Fall 2013 will be "Fundamentals of Toxicology" The Prerequisites has been changed to: a year of undergraduate general biology, two quarters of chemistry, and/or biochemistry.

Student learning goals

Explain dose-response theory;

Describe the processes of absorption, distribution, metabolism, and excretion (ADME) of toxicants

Describe basic principles of genetic toxicology

Define basic principles of toxicokinetics

Describe biochemical mechanisms of toxicity

Describe chemical contribution of carcinogenesis; different stages of carcinogenesis; key molecular players in carcinogenesis

General method of instruction

lectures by faculty

Recommended preparation

a year of undergraduate general biology, two quarters of chemistry, and/or biochemistry.

Class assignments and grading

Handout materials will be provided for most classes.

Additional reference textbook: Casarett and Doull's Toxicology: the Basic Science of Poisons; CD Klaassen, ed.; 8th Edition (2013), and is available at the Health Sciences library.

The final grade for this class will be compiled from 2 in-class exams and one take-home exam, each accounts for 1/3 of the final grade


The information above is intended to be helpful in choosing courses. Because the instructor may further develop his/her plans for this course, its characteristics are subject to change without notice. In most cases, the official course syllabus will be distributed on the first day of class.
Last Update by Zhengui Xia
Date: 08/02/2013